Synthesis, Characterization and Antimicrobial Evaluation of Novel Dimethyl Triazene Incorporated Phenylamino Pyrimidine Derivatives

2021 ◽  
Vol 6 (3) ◽  
pp. 211-216
Author(s):  
Vidhya V. Jadvani ◽  
Yogesh T. Naliapara
Keyword(s):  
Antimicrobial Activity ◽  
1H Nmr ◽  
13C Nmr ◽  
Pyrimidine Derivatives ◽  
In Vitro Antimicrobial Activity ◽  
Fungal Strains ◽  
Elemental Analyses ◽  
Antimicrobial Evaluation ◽  
Hydro Chloride

A series of novel (E)-4-(4-(3,3-dimethyltriaz-1-en-1-yl)phenyl)-N-phenylpyrimidin-2-amine derivatives have been synthesized from the condensation of (E)-3-(dimethylamino)-1-(4-(E)-3,3-dimethyltriaz- 1-en-1-yl)phenyl)prop-2-en-1-one with several guanidinium hydro-chloride. The newly synthesized compounds were examined for in vitro antimicrobial activity against some antibacterial and fungal strains. The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, mass and elemental analyses.

scholarly journals Green Synthetic Protocol for (E)-1-Aryl-3-(2-morpholinoquinolin- 3-yl)prop-2-en-1-ones and Their Antimicrobial Activity

2019 ◽  
Vol 31 (9) ◽  
pp. 1895-1898
Author(s):  
Relangi Siva Subrahmanyam ◽  
Venkateswara Rao Anna
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Mass Spectral Data ◽  
In Vitro Antimicrobial Activity ◽  
Mass Spectral ◽  
Fungal Organisms

We report here an easy, efficient and green synthetic protocol for the (E)-1-aryl-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones by the Claisen-Schmidt condensation of 2-morpholinoquinoline-3-carbaldehyde and different substituted acetophenones by using 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim)BF4. The compounds were characterized by using 1H NMR, 13C NMR and mass spectral data and screened there in vitro antimicrobial activity against different bacterial and fungal organisms.

PTSA-Catalyzed One Pot Domino Synthesis of Dihydropyrido[2,3-d]pyrimidine Derivatives and their Antimicrobial Activity

2021 ◽  
Vol 6 (3) ◽  
pp. 222-227
Author(s):  
Krishna A. Bhensdadia ◽  
Prakash L. Kalavadiya ◽  
Nilam H. Lalavani ◽  
Shipra H. Baluja
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
In Vitro Antimicrobial Activity ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
The One

A novel series of dihydropyrido[2,3-d]pyrimidine derivatives were synthesized by multicomponent domino cyclization via the one-pot three component reaction of 6-amino uracil, substituted aryl aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine in the presence of PTSA 10 mol% as a catalyst. The structures of these synthesized compounds were characterized by spectral analysis. Further the synthesized compounds screened for in vitro antimicrobial activity. Among all the compounds, compound 4b containing flouro substitution exhibited good inhibition against the tested species.

Synthesis and insecticidal activity of 6,8-dichloro-quinazoline derivatives containing a sulfide substructure

2014 ◽  
Vol 68 (7) ◽  
Author(s):  
Jian Wu ◽  
Song Bai ◽  
Min Yue ◽  
Li-Jun Luo ◽  
Qin-Cai Shi ◽  
...  
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Insecticidal Activity ◽  
Plutella Xylostella ◽  
Elemental Analyses ◽  
Quinazoline Derivatives ◽  
Sulfide Group

AbstractA series of 6,8-dichloro-quinazoline derivatives bearing a sulfide group was synthesized and characterized via 1H NMR, 13C NMR, IR and elemental analyses. All the compounds were tested for their insecticidal activity against Plutella xylostella in vitro. The results indicate that the synthesized compounds possess good insecticidal activity. Among these compounds, Vc, Vi, Vj, Vk and Vm displayed 75 %, 85 %, 80 %, 70 % and 63 % activities, respectively. These may prove useful as insecticidal agents.

scholarly journals Synthesis, characterization and anthelmintic activity evaluation of pyrimidine derivatives bearing carboxamide and sulphonamide moieties

2018 ◽  
Vol 83 (4) ◽  
pp. 401-409 ◽  
Author(s):  
David Ugwu ◽  
Uchechukwu Okoro ◽  
Narendra Mishra
Keyword(s):  
Amino Acids ◽  
Boric Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Benzoyl Chloride ◽  
Anthelmintic Activity ◽  
Pharmacological Properties ◽  
Pyrimidine Derivatives ◽  
Different Types

Pyrimidines, sulphonamides and carboxamides have shown a large number of pharmacological properties against different types of diseases including helminthiasis. Seventeen new pyrimidine derivatives bearing sulphonamide and carboxamide were synthesized and investigated for their in vitro anthelmintic properties. Substituted benzenesulphonyl chlorides 15a?c were treated with various amino acids (16a?h) to obtain benzenesulphonamide derivatives 17a?l. Compounds 17a?f were subsequently treated with benzoyl chloride to obtain the N-benzoylated derivatives 19a?f. Further reactions of compounds 19a?f and 17g?l with 4- or 2-aminopyrimidine (20) using boric acid as a catalyst gave the required sulphonamide carboxamide derivatives 21a?q in excellent yields. The compounds were isolated in their analytical grade and characterized using FTIR, 1H-NMR, 13C-NMR and HRMS. The in vitro anthelmintic studies showed that all the synthesized compounds possessed anthelmintic property. Compounds 21a?c, e, g, m and p showed mean paralyzing times of 15, 19, 14, 18, 19, 19 and 18 min, respectively, at 100 mg mL-1 compared to 10 min for albendazole. Compounds 21a?c, g and m had mean death times of 18, 24, 16, 20 and 25 min, respectively, at 100 mg mL-1 compared to 13 min for albendazole.

Synthesis and antimicrobial evaluation of isoxazole-substituted 1,3,4-oxadiazoles

2018 ◽  
Vol 24 (5) ◽  
pp. 285-292 ◽  
Author(s):  
Srinivas Marri ◽  
Ramu Kakkerla ◽  
Mudumba Phali Surya Murali Krishna ◽  
Manchikatla Venkat Rajam
Keyword(s):  
Antimicrobial Activity ◽  
Good Activity ◽  
Fungal Strains ◽  
Antimicrobial Evaluation

Abstract Synthesis of N-(5-methylisoxazol-3-yl)-2-(5-aryl-1,3,4-oxadiazol-2-yl)acetamides 5a–k was achieved from readily available materials. The compounds were screened for their in vitro antimicrobial activity against representative bacterial and fungal strains. Compounds 5b, 5d and 5f exhibit good activity.

Synthesis, Characterization & Antimicrobial Evaluation of New bis(5-Biphenyl-3-alkoxyphenyl-4,5-dihydro-1H-pyrazole-N-carbothioamide) Derivatives

2020 ◽  
Vol 5 (1) ◽  
pp. 77-83
Author(s):  
Shehneela Nisa ◽  
Mohamad Yusuf
Keyword(s):  
13C Nmr ◽  
Ring Closure ◽  
Fungal Strains ◽  
Esi Ms ◽  
Antimicrobial Evaluation ◽  
Antimicrobial Assay ◽  
Tube Dilution

In this study, a series of new symmetrical N-carbothioamide substituted bispyrazolines (2a-f) had been systematically synthesized by using ring closure reactions of bischalcones (1a-f) with thiosemicarbazide under the alkaline-alcoholic conditions. The structures of bisheterocyclic products have been fully characterized on the basis of their IR, 1H & 13C NMR and ESI-MS spectral strategies. All the prepared compounds were also evaluated for their in vitro antimicrobial assay with the help of serial tube dilution procedure against the selected numbers of microbes (seven bacterial and five fungal strains). The most of the synthesized bisheterocycles exhibited noticeable antimicrobial potencies against the tested strains

scholarly journals In vitro Antimicrobial Activity of Some Synthetic Indolium Chloride Derivatives

2020 ◽  
Vol 19 (2) ◽  
pp. 133-137
Author(s):  
Arifa Akther ◽  
Mohammad Rashedul Haque ◽  
Mohammad A Rashid ◽  
Md Wahab Khan
Keyword(s):  
Antimicrobial Activity ◽  
Moderate Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
In Vitro Antimicrobial Activity ◽  
Fungal Strains

A total of eight compounds including four starting materials and four indolium chloride derivatives were tested against Gram positive and Gram negative bacterial and fungal strains. Among them, N-acetyl-2- acetylindoliumchloride (8) exhibited significant antimicrobial activity at a concentration of 200 μg/disc, while the Nacetyl- 2-benzoylindoliumchloride (9) showed moderate activity at 400 μg/disc. At the same time, N-acetyl-2- anisoylindoliumchloride (10) and N-acetyl-2-tolylindoliumchloride (11) demonstrated weak antimicrobial activity. Dhaka Univ. J. Pharm. Sci. 19(2): 133-137, 2020 (December)

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