scholarly journals Stent implantation into ductus arteriosus: a new alternative of palliative treatment of duct-dependent pulmonary circulation

2016 ◽  
Vol 44 (1) ◽  
pp. 30
Author(s):  
Mulyadi M Djer ◽  
Bambang Madiyono ◽  
Sudigdo Sastroasmoro ◽  
Sukman T Putra ◽  
Ismet N Oesman ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Oxygen Saturation ◽  
Stent Implantation ◽  
Pulmonary Circulation ◽  
Ductus Arteriosus ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Case Series Study

Background The technical aspects of ductal stenting have beenreported, but little is known about the fate of the duct after stentimplantation.Objectives To determine the effects of PDA stenting on the degreeof cyanosis, blood oxygen saturation, long-term patency of PDA,and the growth of pulmonary artery and its branches, in patientswith duct-dependent pulmonary circulation.Methods This was a case series study conducted at the Depart-ment of Pediatric Cardiology, Institut Jantung Negara (National HeartInstitute), Kuala Lumpur, Malaysia from November 1996 to Septem-ber 2001 on patients with duct-dependent pulmonary circulation whounderwent stent implantation. All patients were followed-up until oc-clusion or block occurred or until the end of follow-up time. The evalu-ation consisted of clinical manifestations, electrocardiography, chestx-ray, echocardiography, and cardiac catheterization.Results Stent was successfully implanted in 60 patients (84%),failed in 7 patients (10%) and contra indicated in 4 patients (6%).There was significant improvement on the degree of cyanosis afterstent implantation (p<0.0001). The blood oxygen saturation signifi-cantly increased from 74% (ranged 42-93; SD 12) before proce-dure, to 90% (ranged 62-100; SD 8) afterward (p<0.0001). The meanduration of follow-up time was 14.2 months (ranged 2.5-50.8; SD13) and the minimal patency of PDA was 11.2 months (ranged 1.1-47.7; SD 10.7) after implantation. At the end of follow-up, the stentswere widely patent in 33 patients (55%), stenotic in 15 patients (25%)and spontaneously occluded in 12 patients (20%). There was in-creased growth of pulmonary artery as measured by McGoon ratiofrom 1.23 (ranged 0.4-2.3; SD 0.4) to 1.81 (ranged 0.7-0.9; SD 0.57),and no distortion of pulmonary artery and its branches found.Conclusion Stent implantation into ductus arteriosus decreasedthe degree of cyanosis, increased blood oxygen saturation, main-tained long-term patency of ductus arteriosus, and promoted theincreased growth of pulmonary artery without distortion of pulmo-nary artery and its branches

scholarly journals SIMULATION OF THE RELATIONSHIP BETWEEN EXERCISE AND CARDIOPULMONARY FUNCTION AT HIGH ALTITUDE

2021 ◽  
Vol 27 (5) ◽  
pp. 509-513
Author(s):  
Rui Li
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Oxygen Saturation ◽  
High Altitude ◽  
Lower Limb ◽  
Pulmonary Circulation ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Cardiopulmonary Function ◽  
The Relationship

ABSTRACT Introduction: Due to various uncertain and unexpected factors in life such as diseases, natural disasters, traffic accidents, and congenital disabilities, the number and proportion of lower limb amputations are still rising for many reasons, so the research on lower limb prostheses is particularly important. Objective: This work aimed to study the relationship between altitude exercise and cardiopulmonary function. Methods: A model of abnormal changes in cardiopulmonary function was established, and then 40 plateau exercisers were selected, all of whom arrived in Tibet in March 2017. The relationship between pulmonary circulation volume and internal pressure in the chest was observed and compared. The relationship between cardiopulmonary sensory reflex and exercise (high altitude) breathing and heart rate was analyzed. A comparison of the cardiopulmonary function of subjects of different genders was implemented. Moreover, the influence of different altitudes on the subjects’ cardiopulmonary function and the subjects’ cardiopulmonary function changes before departure and during the first, second, and third week after departure were observed and compared. Results: I. As the pressure in the thoracic cavity increased, the subjects’ pulmonary circulation blood volume gradually decreased, and the decrease was most obvious in the stage of thoracic pressure −50 to 0. II. As the cardiorespiratory reflex coefficient increased, the subjects’ breathing and heart rate compensatory acceleration appeared. III. Tracking and monitoring of the subjects’ cardiopulmonary indicators revealed that with the increase in altitude, the subjects’ average arterial pressure, respiratory frequency, and heart rate all showed an upward trend, while the blood oxygen saturation value showed a downward trend. IV. No matter how high the altitude was, the average arterial pressure, respiratory rate, and heart rate monitored of the subjects under exercise were significantly superior to the indicator values under resting state. In contrast, the blood oxygen saturation value showed the opposite trend. V. The subjects’ average arterial pressure, respiration, and heart rate in the first week were higher than other periods, but the blood oxygen saturation was relatively lower. In the second and third weeks, the changes in cardiopulmonary function were relatively smooth (all P<0.05). VI. The changes in the index of the cardiopulmonary function of subjects of different genders were small (p>0.05). Conclusion: Through modeling, the results of the plateau environment on the cardiopulmonary function of the body were made clearer, and these research data provided theoretical references for the training of the sports field in the plateau area. Level of evidence II; Therapeutic studies - investigation of treatment results.

Effects of Long-Term Exposure to High G on Blood Oxygen Saturation and Performance

1992 ◽  
Vol 36 (1) ◽  
pp. 106-110
Author(s):  
Kathy McCloskey ◽  
Stephen Popper ◽  
Daniel Repperger ◽  
Lloyd Tripp
Keyword(s):  
Oxygen Saturation ◽  
Rebound Effect ◽  
Error Rates ◽  
Time To Exhaustion ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Performance Patterns ◽  
And Performance ◽  
Task Conditions

The effects of long term exposure to a high g simulated aerial combat maneuver (SACM, or alternating peaks of +4.5Gz to +7.0Gz) were examined using blood oxygen saturation (SAO2) levels and performance measures (RTs, error rates, and comfort ratings). Four different anti-g protection device configurations were evaluated: the standard issue CSU-13 B/P anti-g suit, an experimental retrograde inflation anti-g suit (RIAGS), the RIAGS with capstan sleeves, and the RIAGS with occlusion cuffs. Overall, RIAGS with sleeves allowed subjects to endure much longer times at high g. However, when SA02 levels were correlated with time to exhaustion, there were no differences between protective suit configurations. RIAGS with sleeves appeared to lead to a slower decrement in blood oxygen saturation levels during long term exposure, allowing subjects to remain at high g longer. It was also shown that SA02 levels “rebounded” to some extent before each of the next +7Gz onsets, but when subjects approached their endurance limits this rebound effect diminished. It seems the longer subjects endured high g, the less able they were to physiologically compensate. The simplest task condition showed an increased in RT when subjects neared their exhaustion point. The more difficult task conditions showed too much variability in RTs to discern any performance patterns. It seemed enough effort and attention was directed to the task to maintain stable performance in the easy condition, but was not enough to maintain performance in the more difficult conditions. Error rates also increased as subjects neared exhaustion, as expected. However, error rates were sensitive to differences among suit configurations, whereas RTs were not. Error rates covaried with time at SACM and comfort ratings. In summary, subjects wearing RIAGS with sleeves withstood high g for longer periods of time, had less error in their performance, and rated the suit most comfortable.

scholarly journals In-Ear SpO2: A Tool for Wearable, Unobtrusive Monitoring of Hypoxaemia in COVID-19

2020 ◽  
Author(s):  
Harry J. Davies ◽  
Ian Williams ◽  
Nicholas S. Peters ◽  
Danilo P. Mandic
Keyword(s):  
Response Time ◽  
Oxygen Saturation ◽  
Index Finger ◽  
Blood Oxygen ◽  
Ear Canal ◽  
Blood Oxygen Saturation ◽  
Long Term Monitoring ◽  
The Right ◽  
Term Monitoring

AbstractNon-invasive ambulatory estimation of blood oxygen saturation has emerged as an important clinical requirement to detect hypoxemia in the delayed post-infective phase of COVID-19, where dangerous hypoxia may occur in the absence of subjective breathlessness. This immediate clinical driver, combined with the general quest for more personalised health data, means that pulse oximetry measurement of capillary oxygen saturation (SpO2) will likely expand into both the clinical and consumer market of wearable health technology in the near future. In this study, we set out to establish the feasibility of SpO2 measurement from the ear canal as a convenient site for long term monitoring, and perform a comprehensive comparison with the right index finger - the conventional clinical measurement site. During resting blood oxygen saturation estimation, we found a root mean square difference of 1.47% between the two measurement sites, with a mean difference of 0.23% higher SpO2 in the right ear canal. Through the simultaneous recording of pulse oximetry from both the right ear canal and index finger during breath holds, we observe a substantial improvement in response time between the ear and finger that has a mean of 12.4 seconds and a range of 4.2 - 24.2 seconds across all subjects. Factors which influence this response time, termed SpO2 delay, such as the sex of a subject are also explored. Furthermore, we examine the potential downsides of ear canal blood oxygen saturation measurement, namely the lower photoplethysmogram amplitude, and suggest ways to mitigate this disadvantage. These results are presented in conjunction with previously discovered benefits such as robustness to temperature, making the case for measurement of SpO2 from the ear canal being both convenient and superior to conventional finger measurement sites for continuous nonintrusive long term monitoring in both clinical and everyday-life settings.

scholarly journals Long-term prognosis of the course of sarcoidosis: analysis of the literature and own experience

2012 ◽  
Vol 93 (2) ◽  
pp. 167-172
Author(s):  
I Yu Vizel
Keyword(s):  
Oxygen Saturation ◽  
Forced Expiratory Volume ◽  
Acute Onset ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Lung Capacity ◽  
Volume Rate ◽  
Long Term Prognosis ◽  
Chronic Course

Aim. To evaluate the prognosis of the course of sarcoidosis in patients with a follow-up term of 10 years or more. Methods. Analysis of the literature, comparison with the data from own research. Analyzed was the data on 15 patients with sarcoidosis with the follow-up term of 10 years or more. Compared were the parameters of spirometry, blood tests, blood oxygen saturation, of the conducted treatment in the patients with remission and with a chronic course. Results. In 8 patients (53.3%) during the last follow-up visit (10 years or more after detection) noted was a stable remission (in 7 after the initial detection and in 1 after a single exacerbation). Among all the 15 patients after 10 years or more the frequency of dyspnea on exertion increased from 33.3 to 46.9%, chest pain - from 6.7 to 20%, complaints of weakness decreased from 66.7 to 53.3%, of fever - from 26.7 to 13.3%, and of cough - from 53.3 to 20%, of erythema nodosum - from 40 to 6.7%, of articular syndrome - from 60 to 20%, of splenomegaly - from 13.3 to 6.7%. When comparing the dynamics of the indicators in the subgroup with persistent remission noted was a significant decrease in the instantaneous volume rate after the exhalation of 50% of the forced vital lung capacity; blood oxygen saturation and diastolic blood pressure significantly increased, the proportion of monocytes in the leukocyte formula decreased. Registered was a significant increase in erythrocyte sedimentation rate within the physiological range. In patients with a chronic course of sarcoidosis occurred a significantly reduction of the forced vital lung capacity, of the forced expiratory volume in 1 s, of the instantaneous volume rate after exhalation of 25% of the forced vital lung capacity. Conclusion. The best prognosis had the patients, who were young adults with an acute onset, and who did not receive glucocorticoids. Pentoxifylline may improve the course and outcome of sarcoidosis.

scholarly journals Transcatheter Closure of Patent Ductus Arteriosus With Severe Pulmonary Artery Hypertension Through Single Venous Approach: a Propensity Score Match Analysis From Long-term Outcomes

2021 ◽  
Author(s):  
Danqing Hu ◽  
En Chen ◽  
Wei Cai ◽  
Lianglong Chen
Keyword(s):  
Pulmonary Artery ◽  
Transcatheter Closure ◽  
Ductus Arteriosus ◽  
Pulmonary Artery Hypertension ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
Short And Long Term ◽  
Baseline Characteristics

Abstract Background: Up to now, transcatheter closure of patent ductus arteriosus(PDA) without severe pulmonary artery hypertension (PAH) has been well established and accepted in clinical practice. However, in PDA patients with severe PAH, transcatheter closure still remains a challenge, regardless of the tremendous advancement in devices and techniques.Methods: We reviewed the records of PDA patients who underwent transcatheter device closure though single femoral venous approach between January 2005 and December 2018. Severe PAH was defined as systolic pulmonary artery pressure (SPAP) measured by a catheter >70mmHg, excluding irreversible severe PAH assessed by trial occlusion. Propensity score matching was used to assemble a cohort of patients with similar baseline characteristics. Results: A total of 29 patients were in severe PAH (SPAH) group after excluding 2 for failing to the trial occlusion, and 468 in non-severe PAH(non-SPAH) group. After matching, 25 patients were in SPAH group, and 39 in non-SPAH group, without any significant difference in baseline characteristics. The median follow-up periods were 57 and 44 months for groups, respectively. No significant difference was noted in the rates of cumulative adverse events in the 2 groups (p=0.208). No poor effects in left ventricular function and residual shunt evaluated by transthoracic echocardiography(TTE) in SPAH group were detected in the short- and long-term follow-up.Conclusion: In the patients with PDA associated with reversible severe PAH, compared to non-severe PAH, transcatheter closure through single venous approach has comparable adverse events rates and successful closure rate, with equivalent results of TTE examination at the short- and long-term follow-up.

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