scholarly journals A Summary Report of FSCJ Workshop “Future Challenges and Opportunities in Developing Methodologies for Improved Human Risk Assessments”

Food Safety ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 83-89
Author(s):  
Kaoruko Tachibana ◽  
George E.N. Kass ◽  
Atsushi Ono ◽  
Takashi Yamada ◽  
Weida Tong ◽  
...  
Keyword(s):  
Risk Assessments ◽  
Summary Report ◽  
Human Risk ◽  
Challenges And Opportunities ◽  
Future Challenges

scholarly journals Dutch Public health Foresight study 2018/20

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
H Hilderink
Keyword(s):  
Public Health ◽  
Health Care ◽  
Health Care Expenditures ◽  
Living Environment ◽  
Societal Challenges ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
National Prevention ◽  
Business As Usual ◽  
Insight Into

Abstract The four-year Public Health Foresight Study (VTV) provides insight into the most important societal challenges for public health and health care in the Netherlands. The seventh edition of the Dutch Public Health Foresight study was published in 2018, with an update in 2020. In this update a business-as-usual or Trend Scenario was developed using 2018 as a base year. In the trend scenario demographic and epidemiological projections have been used to depict the future trends regarding ageing, health, disease, health behaviors, health expenditures and health inequalities. Next, these trends are used to identify the most important future challenges and opportunities for public health. In the 2020 update, special attentions is given to climate change and the local living environment and their impacts and interaction with public health outcomes. Trends in lifestyle-related lifestyle show both positive (smoking prevalence) and negative (overweight prevalence) future developments. Dementia will be the leading cause of mortality and disease burden in 2040 by far. Health care expenditures will double by 2040, with cancers showing the most rapid growth of all disease groups. The insights of this study are directly used as input for the National Health Policy Memorandum and for the National Prevention Accord.

scholarly journals Unconventional Materials Processing Using Spark Plasma Sintering

Ceramics ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 20-40
Author(s):  
Ambreen Nisar ◽  
Cheng Zhang ◽  
Benjamin Boesl ◽  
Arvind Agarwal
Keyword(s):  
Spark Plasma Sintering ◽  
Real Life ◽  
Functional Materials ◽  
Research Field ◽  
Advanced Materials ◽  
Plasma Sintering ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
Gas Quenching ◽  
Spark Plasma

Spark plasma sintering (SPS) has gained recognition in the last 20 years for its rapid densification of hard-to-sinter conventional and advanced materials, including metals, ceramics, polymers, and composites. Herein, we describe the unconventional usages of the SPS technique developed in the field. The potential of various new modifications in the SPS technique, from pressureless to the integration of a novel gas quenching system to extrusion, has led to SPS’ evolution into a completely new manufacturing tool. The SPS technique’s modifications have broadened its usability from merely a densification tool to the fabrication of complex-shaped components, advanced functional materials, functionally gradient materials, interconnected materials, and porous filter materials for real-life applications. The broader application achieved by modification of the SPS technique can provide an alternative to conventional powder metallurgy methods as a scalable manufacturing process. The future challenges and opportunities in this emerging research field have also been identified and presented.

scholarly journals Using chemical biology to assess and modulate mitochondria: progress and challenges

2017 ◽  
Vol 7 (2) ◽  
pp. 20160151 ◽  
Author(s):  
Angela Logan ◽  
Michael P. Murphy
Keyword(s):  
Mitochondrial Function ◽  
Chemical Biology ◽  
Biomedical Sciences ◽  
Interdisciplinary Approaches ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
The Many ◽  
Opening Up

Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such as ROS and metabolites that affect cellular homeostasis, as well as other processes such as cell death and inflammation. Thus, mitochondrial function and dysfunction are central to the health and fate of the cell. Consequently, there is considerable interest in better understanding and assessing the many roles of mitochondria. Furthermore, there is also a growing realization that mitochondrial are a promising drug target in a wide range of pathologies. The application of interdisciplinary approaches at the interface between chemistry and biology are opening up new opportunities to understand mitochondrial function and in assessing the role of the organelle in biology. This work and the experience thus gained are leading to the development of new classes of therapies. Here, we overview the progress that has been made to date on exploring the chemical biology of the organelle and then focus on future challenges and opportunities that face this rapidly developing field.

scholarly journals FDA oversight of NSIGHT genomic research: the need for an integrated systems approach to regulation

2019 ◽  
Author(s):  
Laura V. Milko ◽  
Flavia Chen ◽  
Kee Chan ◽  
Amy M. Brower ◽  
Pankaj B. Agrawal ◽  
...  
Keyword(s):  
Clinical Research ◽  
Systems Approach ◽  
Genomic Sequence ◽  
Clinical Investigation ◽  
Risk Assessments ◽  
Genomic Research ◽  
Institutional Review Boards ◽  
Sequence Information ◽  
Genomic Technologies ◽  
Challenges And Opportunities

ABSTRACTThe National Institutes of Health (NIH) funded the Newborn Sequencing In Genomic medicine and public HealTh (NSIGHT) Consortium to investigate the implications, challenges and opportunities associated with the possible use of genomic sequence information in the newborn period. Following announcement of the NSIGHT awardees in 2013, the Food and Drug Administration (FDA) contacted investigators and requested that pre-submissions to investigational device exemptions (IDE) be submitted for the use of genomic sequencing under Title 21 of the Code of Federal Regulations (21 CFR) part 812. IDE regulation permits clinical investigation of medical devices that have not been approved by the FDA. To our knowledge, this marked the first time the FDA determined that NIH-funded clinical genomic research projects are subject to IDE regulation. Here we review the history of and rationale behind FDA oversight of clinical research and the NSIGHT Consortium’s experiences in navigating the IDE process. Overall, NSIGHT investigators found that FDA’s application of existing IDE regulations and medical device definitions aligned imprecisely with the aims of publicly funded exploratory clinical research protocols. IDE risk assessments by the FDA were similar to, but distinct from, protocol risk assessments conducted by local Institutional Review Boards (IRBs), and had the potential to reflect novel oversight of emerging genomic technologies. However, the pre-IDE and IDE process delayed the start of NSIGHT research studies by an average of 10 months, and significantly limited the scope of investigation in two of the four NIH approved projects. Based on the experience of the NSIGHT Consortium, we conclude that policies and practices governing the development and use of novel genomic technologies in clinical research urgently need clarification in order to mitigate potentially conflicting or redundant oversight by IRBs, NIH, FDA, and state authorities.

scholarly journals Cyberinfrastructure, Cloud Computing, Science Gateways, Visualization, and Cyberinfrastructure Ease of Use

2018 ◽  
pp. 1063-1074 ◽  
Author(s):  
Craig A. Stewart ◽  
Richard Knepper ◽  
Matthew R. Link ◽  
Marlon Pierce ◽  
Eric Wernert ◽  
...  
Keyword(s):  
Ease Of Use ◽  
Research Needs ◽  
Knowledge Infrastructure ◽  
Science Gateways ◽  
Computing Science ◽  
Challenges And Opportunities ◽  
Utility Of Information ◽  
Future Challenges ◽  
New Research ◽  
The Impact

Computers accelerate our ability to achieve scientific breakthroughs. As technology evolves and new research needs come to light, the role for cyberinfrastructure as “knowledge” infrastructure continues to expand. In essence, cyberinfrastructure can be thought of as the integration of supercomputers, data resources, visualization, and people that extends the impact and utility of information technology. This article discusses cyberinfrastructure, the related topics of science gateways and campus bridging, and identifies future challenges and opportunities in cyberinfrastructure.

scholarly journals Future challenges and opportunities in brand management: An introduction to a commemorative special issue

2014 ◽  
Vol 21 (9) ◽  
pp. 685-688 ◽  
Author(s):  
Tim Oliver Brexendorf ◽  
Joachim Kernstock ◽  
Shaun M Powell
Keyword(s):  
Brand Management ◽  
Special Issue ◽  
Challenges And Opportunities ◽  
Future Challenges
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