scholarly journals Congenital defects in the immune system in the Stavropol region

2021 ◽  
Vol 16 (2) ◽  
Author(s):  
Lyudmila Barycheva ◽  
Lyudmila Sergeevna Khachirova ◽  
Lyudmila Sergeevna Khachirova ◽  
Marina Golubeva ◽  
Leila Timurovna Kubanova
Keyword(s):  
Immune System ◽  
Congenital Defects ◽  
Stavropol Region

scholarly journals Congenital Defects in Neutrophil Dynamics

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Marton Keszei ◽  
Lisa S. Westerberg
Keyword(s):  
Immune System ◽  
Bacterial Infections ◽  
Turnover Rate ◽  
Vesicular Trafficking ◽  
Congenital Defects ◽  
Neutrophil Granulocytes ◽  
High Turnover ◽  
Effector Cells ◽  
Vertebrate Immune System ◽  
Cytoskeletal Rearrangements

Neutrophil granulocytes are key effector cells of the vertebrate immune system. They represent 50–70% of the leukocytes in the human blood and their loss by disease or drug side effect causes devastating bacterial infections. Their high turnover rate, their fine-tuned killing machinery, and their arsenal of toxic vesicles leave them particularly vulnerable to various genetic deficiencies. The aim of this review is to highlight those congenital immunodeficiencies which impede the dynamics of neutrophils, such as migration, cytoskeletal rearrangements, vesicular trafficking, and secretion.

Diseases Caused by Genetic or Congenital Defects in the Immune System or Skin Immune System

2016 ◽  
pp. 259-277
Author(s):  
Albert Gutierrez ◽  
Mark R. Pittelkow ◽  
Liyan Xi ◽  
Xiaowen Huang ◽  
Sweta Rai
Keyword(s):  
Immune System ◽  
Congenital Defects ◽  
Skin Immune System

Learned Placebo Effects in the Immune System

2014 ◽  
Vol 222 (3) ◽  
pp. 148-153 ◽  
Author(s):  
Sabine Vits ◽  
Manfred Schedlowski
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Associative Learning ◽  
Placebo Response ◽  
Immunosuppressive Drug ◽  
Immune Functions ◽  
Placebo Effects ◽  
New Therapeutic Approaches ◽  
Biological Variables ◽  
Experimental Approaches

Associative learning processes are one of the major neuropsychological mechanisms steering the placebo response in different physiological systems and end organ functions. Learned placebo effects on immune functions are based on the bidirectional communication between the central nervous system (CNS) and the peripheral immune system. Based on this “hardware,” experimental evidence in animals and humans showed that humoral and cellular immune functions can be affected by behavioral conditioning processes. We will first highlight and summarize data documenting the variety of experimental approaches conditioning protocols employed, affecting different immunological functions by associative learning. Taking a well-established paradigm employing a conditioned taste aversion model in rats with the immunosuppressive drug cyclosporine A (CsA) as an unconditioned stimulus (US) as an example, we will then summarize the efferent and afferent communication pathways as well as central processes activated during a learned immunosuppression. In addition, the potential clinical relevance of learned placebo effects on the outcome of immune-related diseases has been demonstrated in a number of different clinical conditions in rodents. More importantly, the learned immunosuppression is not restricted to experimental animals but can be also induced in humans. These data so far show that (i) behavioral conditioned immunosuppression is not limited to a single event but can be reproduced over time, (ii) immunosuppression cannot be induced by mere expectation, (iii) psychological and biological variables can be identified as predictors for this learned immunosuppression. Together with experimental approaches employing a placebo-controlled dose reduction these data provide a basis for new therapeutic approaches to the treatment of diseases where a suppression of immune functions is required via modulation of nervous system-immune system communication by learned placebo effects.

Congenital defects: An evaluation and assessment of the state of the science

1981 ◽  
Author(s):  
Allen S. Goldman ◽  
James W. Lash ◽  
Delbert Dayton ◽  
Daniel Nebert
Keyword(s):  
The State ◽  
Congenital Defects ◽  
State Of The Science ◽  
Evaluation And Assessment
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