A Rare Case of Obstructive Jaundice Secondary to Multiple Myeloma

Light chain multiple myeloma (LCMM) initiates approximately 15 percentage of patients with multiple myeloma (MM). It has a lower prognosis when compared with the variant immunoglobulin (Ig) G or IgA. We report a rare case on Light chain multiple myeloma in 49-year-old male patient who presented with acute kidney injury, hypercalcemia. histopathology examination was found to be plasmacytoma, kappa restricted; and free kappa lamda chain in urine and serum was found to be greater. Bone pain and renal dysfunction were the most common prevalent initial signs and symptoms while extramedullary disease (EMD) was later acquired during disease. Bortezomib demonstrated superior efficacy over nonbortezomib in LCMM patients.

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AB228. SOH21AS200. A rare case of incidental functioning neck paraganglioma in a multiple myeloma patient

Mesentery and Peritoneum ◽

10.21037/map-21-ab228 ◽

2021 ◽

Vol 5 ◽

pp. AB228-AB228

Author(s):

Waris Ali Shah ◽

Zeeshan Razzaq ◽

Hamid Mustafa ◽

Sarah Lungley ◽

Mohammed Daoud ◽

...

Keyword(s):

Multiple Myeloma ◽

Rare Case ◽

Myeloma Patient ◽

Multiple Myeloma Patient

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Mucin-filled CBD, difficult to manage cholangitis

BMJ Case Reports ◽

10.1136/bcr-2020-238363 ◽

2021 ◽

Vol 14 (1) ◽

pp. e238363

Author(s):

Manish Kumar ◽

Ujjwal Sonika ◽

Sanjeev Sachdeva ◽

Ashok Dalal

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Obstructive Jaundice ◽

Rare Case ◽

Malignant Potential ◽

Cystic Neoplasm ◽

Stricture Formation ◽

Intraductal Papillary Mucinous Neoplasms ◽

Mucinous Neoplasms ◽

Optimum Management

Intraductal papillary mucinous neoplasms (IPMNs) are mucin-secreting cystic neoplasm of pancreas. They have a malignant potential. They are usually localised to the pancreas but occasionally can involve surrounding structures (1.9%–6.6%), like bile duct and duodenum, and are labelled as IPMN with invasion. Jaundice as a manifestation of IPMN is not common (4.5%). It can present as jaundice as a result of invasion of common bile duct (CBD) resulting in stricture formation or uncommonly as a result of fistulising to CBD with resultant obstruction of CBD by thick mucin secreted by this tumour. As only few cases (around 23) of mucin-filled CBD are reported in the literature. We are presenting our experience in dealing a rare case of obstructive jaundice caused by IPMN fistulising into CBD, highlighting the difficulties faced in managing such case, especially with regards to biliary drainage and what can be the optimum management in such cases.

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A Rare Case of Extramedullary Relapse of Multiple Myeloma Causing Bowel Obstruction

Case Reports in Hematology ◽

10.1155/2019/4962678 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Prarthna V. Bhardwaj ◽

Shrinkhala Khanna ◽

Majd D. Jawad ◽

Syed S. Ali

Keyword(s):

Multiple Myeloma ◽

Bowel Obstruction ◽

Rare Case ◽

Soft Tissues ◽

Plasma Cells ◽

Case Reports ◽

Rare Entity ◽

Risk Gene ◽

Gene Profiles ◽

Extramedullary Relapse

Extramedullary myeloma, defined by presence of plasma cells outside the bone marrow, is a rare entity accounting for about 3–9% of all cases. It usually is aggressive with a median survival of <6 months. It is also associated with adverse prognostic factors including 17p deletions and high-risk gene profiles. While common extramedullary sites include bones, there have been several case reports of hematogenous extramedullary myeloma to the liver, lungs, pancreas, breast, skin, and soft tissues. Extramedullary myeloma to the mesentery is a rare entity with only a handful of cases reported. We present a case of 69-year-old man presenting with relapse of multiple myeloma to the mesentery, resulting in bowel obstruction to highlight the various presentations of myeloma.

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Raised ?2-Microglobulin as a Surrogate Marker in Non-Secretory Multiple Myeloma

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v16i1.31146 ◽

2017 ◽

Vol 16 (1) ◽

pp. 142-145

Author(s):

Bimal K Agrawal ◽

Anshul Sehgal ◽

Vikas Deswal ◽

Prem Singh ◽

Usha Agrawal

Keyword(s):

Multiple Myeloma ◽

Bone Marrow ◽

Rare Case ◽

Plasma Cells ◽

Medical Science ◽

Protein A ◽

Surrogate Marker ◽

M Protein ◽

Review Of Literature ◽

Lytic Lesions

Multiple myeloma is a neoplasm of plasma cells in the bone marrow. It is characterised by lytic lesions in the bones, marrow plasmacytosis and presence of M protein in serum and/or urine. Serum ?2 microglobulin is also raised and can be used for classification and prognostication of the disease. In the absence of M protein, the disease is known as non-secretory myeloma. It is proposed that raised ?2 microglobulin can be used for diagnosis and therapeutic guidance in the absence of M protein. A rare case of nonsecretory myeloma with neurocognitive impairment along with review of literature is being presented. The patient had multiple lytic lesions in bones with marked increase in plasma cells in bone marrow. M protein was not detectable in serum or urine but serum ?2 microglobulin was much elevated.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.142-145

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Rare case of solitary plasmacytoma of the skull in a young male patient

South African Journal of Radiology ◽

10.4102/sajr.v21i1.1133 ◽

2017 ◽

Vol 21 (1) ◽

Author(s):

Swati Singh ◽

Vaishali Upadhyaya ◽

Rajat Agarwal ◽

Ratni B. Gujral

Keyword(s):

Elderly Patient ◽

Multiple Myeloma ◽

Male Patient ◽

Rare Case ◽

Osteolytic Lesion ◽

Young Male ◽

Axial Skeleton ◽

Solitary Plasmacytoma ◽

Age Group ◽

Rare Entity

Solitary plasmacytoma of bone without signs of multiple myeloma is a rare entity. It usually presents as an osteolytic lesion in the axial skeleton of an elderly patient. Here, we report a case of solitary plasmacytoma in the skull of a young male patient which emphasises the need to consider it in the differential diagnosis of a destructive calvarial mass lesion even in this age group.

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