Adverse Event Profile of Eluxadoline Over Time in Patients With Irritable Bowel Syndrome With Diarrhea

Background—Life stress contributes to symptom onset and exacerbation in the majority of patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD); research evidence is conflicting, however, as to the strength of these effects.Aims—To test prospectively the relation of chronic life stress threat to subsequent symptom intensity over time.Patients—One hundred and seventeen consecutive outpatients satisfying the modified Rome criteria for IBS (66% with one or more concurrent FD syndromes) participated.Methods—The life stress and symptom intensity measures were determined from interview data collected independently at entry, and at six and 16 months; these measures assessed the potency of chronic life stress threat during the prior six months or more, and the severity and frequency of IBS and FD symptoms during the following two weeks.Results—Chronic life stress threat was a powerful predictor of subsequent symptom intensity, explaining 97% of the variance on this measure over 16 months. No patient exposed to even one chronic highly threatening stressor improved clinically (by 50%) over the 16 months; all patients who improved did so in the absence of such a stressor.Conclusion—The level of chronic life stress threat predicts the clinical outcome in most patients with IBS/FD.

Download Full-text

Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time

Gastroenterology ◽

10.1016/0016-5085(95)90373-9 ◽

1995 ◽

Vol 109 (3) ◽

pp. 671-680 ◽

Cited By ~ 442

Author(s):

Lars Agréus ◽

Kurt Svärdsudd ◽

Olof Nyrén ◽

Gösta Tibblin

Keyword(s):

Irritable Bowel Syndrome ◽

General Population ◽

Irritable Bowel ◽

Over Time

Download Full-text

Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study)

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2006.03197.x ◽

2007 ◽

Vol 25 (3) ◽

pp. 323-332 ◽

Cited By ~ 41

Author(s):

V. GARRIGUES ◽

F. MEARIN ◽

X. BADÍA ◽

A. BALBOA ◽

J. BENAVENT ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Bowel Habit ◽

Change Over Time ◽

Follow Up Study ◽

Irritable Bowel ◽

Over Time

Download Full-text

Improvements over Time in Individual Diarrhea-Predominant Irritable Bowel Syndrome Symptoms (IBS-D) with Rifaximin Repeat Treatment

The American Journal of Gastroenterology ◽

10.14309/00000434-201610001-00530 ◽

2016 ◽

Vol 111 ◽

pp. S240

Author(s):

Mark Pimentel ◽

Anthony J. Lembo ◽

Ray Wolf

Keyword(s):

Irritable Bowel Syndrome ◽

Repeat Treatment ◽

Irritable Bowel ◽

Over Time

Download Full-text

Female Pelvic Pain: Assessment

10.2310/obg.19012 ◽

2020 ◽

Author(s):

Mario Castellanos ◽

Louise P King

Keyword(s):

Irritable Bowel Syndrome ◽

Pelvic Floor ◽

Pelvic Pain ◽

Chronic Pelvic Pain ◽

Visceral Pain ◽

Pelvic Floor Dysfunction ◽

Pudendal Neuralgia ◽

Somatic Pain ◽

Irritable Bowel ◽

Over Time

Chronic pelvic pain (CPP) in women is responsible for greater than 10% of referrals to gynecologists. A majority of them will remain undiagnosed or inadequately treated. Over time, CPP may lead to a syndrome that results in disability, loss of employment, and discord within relationships. This review discusses how to achieve a comprehensive assessment of CPP from a variety of causes. This review contains 13 figures, 5 tables and 60 references Key Words: dysmenorrhea, dyspareunia, endometriosis, interstitial cystitis, irritable bowel syndrome, pelvic floor dysfunction, pelvic pain, pudendal neuralgia, somatic pain, visceral pain

Download Full-text