Efficacy and Safety of Tacrolimus Therapy for Severe and Steroid-refractory Ulcerative Colitis: A Systematic Review and Meta-analysis

2015 ◽  
Vol 110 ◽  
pp. S828-S829
Author(s):  
Yuga Komaki ◽  
Fukiko Komaki ◽  
Atsushi Sakuraba
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Tacrolimus Therapy ◽  
Steroid Refractory

scholarly journals Efficacy and safety of Shenling Atractylodes Powder in the treatment of ulcerative colitis: a systematic review and Meta analysis

2021 ◽  
Author(s):  
Quanhui Zhang ◽  
Yongwen Deng ◽  
Jinlong Wang ◽  
Feihong Huang ◽  
Yiduo Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Meta Analysis ◽  
Efficacy And Safety

scholarly journals Efficacy and Safety of Vedolizumab in the Treatment of Ulcerative Colitis: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 21 ◽  
pp. S82
Author(s):  
R Thode ◽  
P Veeranki ◽  
A Inuganti ◽  
G Paladugu ◽  
RK Hyderboini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Meta Analysis ◽  
Efficacy And Safety

Tacrolimus Therapy in Steroid-Refractory Ulcerative Colitis: A Review

2019 ◽  
Vol 26 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Biyu Wu ◽  
Jinglu Tong ◽  
Zhihua Ran
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Process ◽  
Calcineurin Inhibitor ◽  
Efficacy And Safety ◽  
Chronic Inflammatory Process ◽  
Increased Risk ◽  
Bowel Diseases ◽  
Tacrolimus Therapy ◽  
Inflammatory Bowel ◽  
Steroid Refractory

AbstractInflammatory bowel diseases are known for a chronic inflammatory process of the gastrointestinal tract and include Crohn’s disease and ulcerative colitis (UC). Patients who are dependent on or resistant to corticosteroids account for about 20% of severe UC patients. Tacrolimus is a calcineurin inhibitor that has recently been used in the treatment of steroid-refractory ulcerative colitis. Tacrolimus has been demonstrated to have remarkable therapeutic efficacy in UC patients, without increased risk of severe adverse effects such as induction of remission and maintenance therapy. This article reviews the mechanism of action, pharmacogenetics, efficacy, and safety of tacrolimus for patients with steroid-refractory ulcerative colitis.

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