Case Report of a Unique but Likely Not Uncommon Etiology of a Markedly Elevated Serum Carbohydrate Antigen 19-9 (CA 19-9)

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S829
Author(s):  
Jared Sninsky ◽  
Charles A. Sninsky ◽  
Troy Hampton ◽  
Christopher Cassisi
Keyword(s):  
Case Report ◽  
Elevated Serum ◽  
Carbohydrate Antigen ◽  
Serum Carbohydrate Antigen

scholarly journals Correlation between serum carbohydrate antigen 19-9 levels and computed tomography severity score in patients with nontuberculous mycobacterial pulmonary disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kangjoon Kim ◽  
Seung Hyun Yong ◽  
Su Hwan Lee ◽  
Sang Hoon Lee ◽  
Ah Young Leem ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Disease Activity ◽  
Pulmonary Disease ◽  
Severity Score ◽  
Partial Correlation ◽  
Elevated Serum ◽  
Carbohydrate Antigen ◽  
Chest Ct ◽  
Clinical Biomarker ◽  
Serum Carbohydrate Antigen

AbstractThere is no validated clinical biomarker for disease severity or treatment response for nontuberculous mycobacterial pulmonary disease (NTM-PD). We investigated the correlation between elevated serum carbohydrate antigen (CA) 19-9 levels and NTM-PD disease activity, defined using an imaging severity score based on chest computed tomography (CT). We retrospectively examined 79 patients with NTM-PD who underwent serum CA19-9 level assessments and chest CT less than 1 month apart. NTM-PD severity was rated using a CT-based scoring system. The correlation between the CT score and serum CA19-9 levels was evaluated. Chest CT revealed nodular bronchiectasis without cavitation in most patients (78.5%). Serum CA19-9 levels were elevated in 19 (24%) patients. Serum CA19-9 levels were positively correlated with the total CT score and bronchiectasis, bronchiolitis, cavity, and consolidation subscores. Partial correlation analysis revealed a significant positive correlation between serum CA19-9 levels and CT scores for total score and bronchiectasis, bronchiolitis, cavitation, and consolidation subscores after controlling for age, sex, and BMI. Serum CA19-9 levels were positively correlated with the CT severity score for NTM-PD. Serum CA19-9 may be useful in evaluating disease activity or therapeutic response in patients with NTM-PD.

Simple cholangitis induces extremely and recurrently elevated serum carbohydrate antigen 19-9 level

2019 ◽  
Vol 18 (3) ◽  
pp. 294-295 ◽  
Author(s):  
Ding-Li Xu ◽  
Yi-Qun Wu ◽  
Chang Xin ◽  
Qi-Feng Zhou ◽  
Ming-Liang Chen ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Carbohydrate Antigen ◽  
Serum Carbohydrate Antigen

scholarly journals Serum Carbohydrate Antigen 199 as a Biomarker for Evaluating Patients with Choledocholithiasis

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Wang Gu ◽  
Zhong Tong
Keyword(s):  
Correlation Analysis ◽  
White Cell Count ◽  
Elevated Serum ◽  
Serum Levels ◽  
Carbohydrate Antigen ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Serum Carbohydrate Antigen ◽  
The Difference ◽  
White Blood Cell Counts

Aims. Choledocholithiasis is a common and yet potentially debilitating disease of the biliary tract. While certain patients with this disease remain largely asymptomatic or experience mild discomfort, in several cases, patient can suffer biliary inflammation and other serious symptoms. Previous studies have detected elevated serum levels of carbohydrate antigen 199 in patients with choledocholithiasis. We wanted to know whether serum CA199 level in patients with choledocholithiasis is related to the level of inflammation in patients. Methods. In the present study, we separated a cohort of 135 choledocholithiasis patients into two groups based on their white blood cell counts, which were either 3.5−9.5×109/L or ≥9.5×109/L. We also divided patients into two groups according to CPR < 10 mg/L and CRP ≥ 10 mg/L. At the same time, the correlation between CA199 and CRP level was analyzed. Results. We then used a Rank-sum test to compare serum carbohydrate 199 levels between these groups, revealing significantly higher levels of this antigen in patients with a white cell count ≥9.5×109/L (Z=−3.584, P<0.01). The two groups were grouped by CRP, and the CA199 level was compared. The difference between the two groups was statistically significant (P<0.01). The correlation analysis between CA199 and CRP showed an obvious correlation (r=0.574). Conclusion. This suggests that in patients with choledocholithiasis, higher circulating carbohydrate antigen 199 levels may correspond to a higher degree of inflammation.

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