The Independent Association Between Age and Serum Cholesterol Levels in Patients with Familial Hypercholesterolemia

(1) Background: Studies have suggested that age and the serum total cholesterol (TC) concentration are independent risk factors for cardiovascular disease (CVD) in patients with familial hypercholesterolemia (FH); however, the relationship between age and TC in patients with FH is unclear. We aimed to investigate the correlation between age and TC in patients with FH. (2) Methods: In this retrospective, controlled not matched analysis, a total of 103 patients with FH and 106 non-FH controls were recruited into the study from 2004 to 2017. Spearman and partial correlation analyses, as well as multiple regression analyses, were used to evaluate the relationship between TC and age. (3) Results: There were no significant differences in age, gender, or BMI between the FH group and the control group (p > 0.05). Family history of CVD, TC, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), lipoprotein (a) (Lp(a)) and non-HDL-C levels were significantly higher in patients with FH compared to the control (p < 0.01). Additionally, the serum TC levels for ages ≥ 50 years were significantly higher than those for ages < 50 years (p < 0.05) in FH patients. In both Spearman and partial correlation analyses, age was found to be significantly correlated with serum TC (p < 0.001) in the FH group but not in the control group, which was confirmed by further multiple linear regression analyses and logistic regression analyses. (4) Conclusions: Age is an independent factor influencing serum TC level in patients with FH, and it is necessary to conduct early screening and early intervention.

Multiscale Partial Correlation Clustering of Stock Market Returns

This study proposes a wavelet procedure for estimating partial correlation coefficients between stock market returns over different time scales. The estimated partial correlations are subsequently used in a cluster analysis to identify, for each time scale, groups of stocks that exhibit distinct market movement characteristics and are therefore useful for portfolio diversification. The proposed procedure is demonstrated using all the major S&P 500 sector indices as well as precious metals and energy sector futures returns during the last decade. The results suggest cluster formations that vary by time scale, which entails different stock selection strategies for investors differing in terms of their investment horizon orientation.

Iron Deposition in Gray Matter Nuclei of Patients With Intracranial Artery Stenosis: A Quantitative Susceptibility Mapping Study

Purpose: This study aimed to use quantitative susceptibility mapping (QSM) to systematically investigate the changes of iron content in gray matter (GM) nuclei in patients with long-term anterior circulation artery stenosis (ACAS) and posterior circulation artery stenosis (PCAS).Methods: Twenty-five ACAS patients, 25 PCAS patients, and 25 age- and sex-matched healthy controls underwent QSM examination. Patients were scored using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) to assess the degree of neural function deficiency. On QSM images, iron related susceptibility of GM nuclei, including bilateral caudate nucleus, putamen (PU), globus pallidus (GP), thalamus (TH), substantia nigra (SN), red nucleus, and dentate nucleus (DN), were assessed. Susceptibility was compared between bilateral GM nuclei in healthy controls, ACAS patients, and PCAS patients. Partial correlation analysis, with age as a covariate, was separately performed to assess the relationships of susceptibility with NIHSS and mRS scores.Results: There were no significant differences between the susceptibilities for left and right hemispheres in all seven GM nucleus subregions for healthy controls, ACAS patients, and PCAS patients. Compared with healthy controls, mean susceptibility of bilateral PU, GP, and SN in ACAS patients and of bilateral PU, GP, SN, and DN in PCAS patients were significantly increased (all P &lt; 0.05). In addition, mean susceptibility of bilateral TH and SN in PCAS patients was significantly higher than in ACAS patients (both P &lt; 0.05). With partial correlation analysis, mean susceptibility at bilateral PU of ACAS patients was significantly correlated with mRS score (r = 0.415, P &lt; 0.05), and at bilateral PU in PCAS patients was correlated with NIHSS score (r = 0.424, P &lt; 0.05).Conclusion: Our findings indicated that abnormal iron metabolism may present in different subregions of GM nuclei after long-term ACAS and PCAS. In addition, iron content of PU in patients with ACAS and PCAS was correlated with neurological deficit scores. Therefore, iron quantification measured by QSM susceptibility may provide a new insight to understand the pathological mechanism of ischemic stroke caused by ACAS and PCAS.

Large household reduces dementia mortality.

Background Large households/families create more positive psychological well-being which may offer a life course protection against dementia development and deliver more comprehensive healthcare to dementia patients. Methods Dementia specific mortality rates of the 183 member states of World Health Organization were calculated and matched with the respective country data on household size, Gross Domestic Product (GDP), urban and ageing. Scatter plots were produced to explore and visualize the correlations between household size and dementia mortality rates. Pearsons and nonparametric correlations were used to evaluate the strength and direction of the associations between household size and all other variables. Partial correlation of Pearsons moment-product approach was used to identify that household size protects against dementia regardless of the competing effects from ageing, GDP and urbanization. Multiple regression identified large household was a significant predictor of dementia mortality. Results Household size was in a negative and moderately strong correlation (r = -0.6034, p < 0.001) with dementia mortality. This relationship was confirmed in both Pearson r (r= - 0.524, p<0.001) and nonparametric (rho = -0.579, p < 0.001) analyses. Regardless of the contribution of ageing, SES and urban lifestyle to dementia mortality, large household was an independent predictor of dementia mortality (r = −0.331, p <0.001) in partial correlation analysis. Stepwise multiple regression analysis selected large household as the variable having the greatest contribution to dementia mortality with R2 = 0.263 while ageing was placed second increasing R2 to 0.259. GDP and urbanization were removed as having no statistically significant influence on dementia mortality. Conclusions Independent of ageing, urbanization and GDP, large household protects against dementia mortality. As part of dementia prevention, healthcare practitioners should encourage people to increase their positive interactions with persons from their neighbourhood or other fields where large household/family size is hard to achieve.

Pengaruh Mutu Produk, Persepsi Harga Dan Variasi Produk Terhadap Keputusan Pembelian Konsumen (Studi Kasus Pada Toko Serba 45.000 Ditenggarong)

The purpose of this study was to determine the effect of product quality and price perception partially or simultaneously on consumer perceptions at 45,000 Convenience Stores in Tenggarong and to determine the dominant variables in influencing consumer perceptions between the two independent variables. The analytical tool used in this research is multiple regression method with the help of SPSS 20.0 For Window's, with a population of 150 respondents and a sample of 70 respondents. Based on the results of the study, it can be concluded that the variables of product quality, price perception and product variations simultaneously affect consumer purchasing decisions. Product quality variable has a partial effect on consumer purchasing decisions at 45,000 Convenience Stores in Tenggarong. Price perception variable (X2) partially influences consumer purchasing decisions at 45,000 Convenience Stores in Tenggarong, Product variation variable (X3) partially affects consumer purchasing decisions at 45,000 Convenience Stores in Tenggarong. From the three partial correlation test results, it can be seen that the value of the product quality variable has the greatest influence compared to the price perception variable and product variation, so that the product quality variable is the most dominant variable influencing consumer purchasing decisions. Keywords: Product Quality, Price Perception, Product Variation, Purchase Decision

Mineral Uptake, Total Polyphenols and Total Flavonoids of Barley as Affected by Tillage Practices under Semi-Arid Conditions

Aims: Conservation agriculture has been recommended as an option to mitigate climate change impact when practicing conventional, to ensure sustainability and food security This study examined the effect of conventional tillage (CT) and no tillage (NT) on mineral elements uptake, total phenolic content (TPC) and total flavonoid content (TFC) of barley. Study Design: Split-plot design was applied for this study. Place and Duration of Study: The experiment was conducted in ESAK station (Boulifa, kef, North West Tunisia) during 2016/2017 cultivation year. Methodology: Mineral elements uptake, total phenolic content (TPC) and total flavonoid content (TFC) of barley were studied as affected by conventional tillage (CT) and no tillage (NT) for tillering and grain filling stages. Results: The results showed that tillage practices (T) had no significant effect on mineral uptake, total phenolic content and total flavonoids content under rainfed conditions. The stage (S) had showed significant effects on P, Ca and Na amounts for both tillage practices when it had no effect on K amount. The interaction T x S had no significant effect on mineral elements concentrations and TFC. However, this interaction had affected TPC significantly. Phosphorous (P) showed high significant positive correlations with Ca and Na. In addition, P presented high significant negative correlations with TPC and TFC. For partial correlation based on Tillage practices, similar correlations values were noted. Considering the partial correlation based on plant stages, no significant correlations had been noted. Conclusion: This work enlarges our knowledge on barley mineral elements uptake, TPC and TFC as influenced by tillage practices aiding decision makers in increasing no tillage adoption in Tunisia under rainfed conditions.

Correlation of Neuropsychiatric Symptoms in Dementia with Brain Perfusion: A 99mTc-SPECT-HMPAO Study with Brodmann Areas Analysis

Background: Neuropsychiatric symptoms (NPSs) are common in dementia. Their evaluation is based on Neuropsychiatric Inventory (NPI). Neuroimaging studies have tried to elucidate the underlying neural circuits either in isolated NPSs or in specific forms of dementia. Objective: : The objective of this study is to evaluate the correlation of NPS in the NPI with Brodmann areas (BAs) perfusion, for revealing BAs involved in the pathogenesis of NPSs in dementia of various etiologies. Method: We studied 201 patients (82 with Alzheimer's disease, 75 with Frontotemporal dementia, 27 with Corticobasal Syndrome, 17 with Parkinson Disease/Lewy Body Dementia). Exploratory factor analysis was carried out to evaluate underlying groups of BAs, and Principal Component analysis was chosen as extraction method using Varimax rotation. Partial correlation coefficients were computed to explore the association of factors obtained from analysis and NPI items controlling for age, educational yeas, and ACE-R. Results: We found 6 BAs Factors(F); F1 (BAs 8,9,10,11,24,32,44,45,46,47, bilaterally), F2 (Bas 4,5,6,7,23,31, bilaterally), F3 (BAs 19,21,22,37,39,40, bilaterally), F4 (BAs 20,28,36,38, bilaterally), F5 (BAs 25, bilaterally) and F6 (BAs 17,18, bilaterally). Significant and negative correlation was found between NPI1 (delusions) and F3,F6, NPI2 (hallucinations) and F6, NPI7 (apathy) and F1,F4,F5, NPI3 (agitation) - NPI10 (aberrant motor behavior) - NPI12 (eating disorders) and F1. We did not find any significant correlation for NPI4,5,6,8,9,11 (depression, anxiety, euphoria, disinhibition, irritability, sleep disorders, respectively). Conclusion: Several NPSs share the same BAs among different types of dementia, while the manifestation of the rest may be attributed to different neural networks. These findings may have an impact on patients’ treatment.

Examining the distinction between self-enhancement and self-protection in young adults: The roles of basic need satisfaction and psychological adjustment

The current study explores the distinction between self-enhancement and self-protection as regards basic need satisfaction (i.e., autonomy, competence, and relatedness) and psychological adjustment (i.e., global and contingent types of self-esteem and intolerance of uncertainty) in young adults. 531 undergraduates (365 females and 166 males) completed questionnaires assessing self-enhancement and self-protection, basic need satisfaction, global self-esteem, contingent self-esteem, and intolerance of uncertainty tendencies. Correlation, partial correlation, and hierarchical regression analyses were used. The results revealed that self-enhancement and self-protection were differently associated with basic need satisfaction and the other indicators of psychological adjustment. Accordingly, self-enhancement was positively predicted by need satisfaction and global self-esteem. However, self-protection was negatively predicted by these variables but positively predicted by the contingent type of self-esteem and intolerance of uncertainty. The results suggest that self-enhancement and self-protection are distinct motives. Self-enhancement is linked to psychological adjustment; whereas, self-protection is related to psychological maladjustment.

Pengaruh Iklim Organisasi Dan Pengembangan Karir Terhadap Semangat Kerja Karyawan Pada PT. Mahakam Energi Berkah

The purpose of this study was to determine the effect of organizational climate variables and career development on employee work spirit simultaneously and partially. In addition, to determine the most dominant variable affecting employee work spirit at PT. Mahakam Energy Blessing in Tenggarong Seberang. The responden in this study were all production employees at PT. The Mahakam of Blessing Energy numbered 93 people. The analytical tool used is qualitative analysis with multiple regression models. Based on the simultaneous test table, it can be concluded that the variable organizational climate and career development simultaneously affect employee morale. Organizational climate and career development variables have a partial effect on employee morale. From the two partial correlation test results, it can be seen that the value of the organizational climate variable is the largest compared to the career development variable, so that the organizational climate variable is the most dominant variable affecting work morale. Keywords: Organizational Climate, Career Development, Work Spirit