scholarly journals Correlation between serum carbohydrate antigen 19-9 levels and computed tomography severity score in patients with nontuberculous mycobacterial pulmonary disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kangjoon Kim ◽  
Seung Hyun Yong ◽  
Su Hwan Lee ◽  
Sang Hoon Lee ◽  
Ah Young Leem ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Disease Activity ◽  
Pulmonary Disease ◽  
Severity Score ◽  
Partial Correlation ◽  
Elevated Serum ◽  
Carbohydrate Antigen ◽  
Chest Ct ◽  
Clinical Biomarker ◽  
Serum Carbohydrate Antigen

AbstractThere is no validated clinical biomarker for disease severity or treatment response for nontuberculous mycobacterial pulmonary disease (NTM-PD). We investigated the correlation between elevated serum carbohydrate antigen (CA) 19-9 levels and NTM-PD disease activity, defined using an imaging severity score based on chest computed tomography (CT). We retrospectively examined 79 patients with NTM-PD who underwent serum CA19-9 level assessments and chest CT less than 1 month apart. NTM-PD severity was rated using a CT-based scoring system. The correlation between the CT score and serum CA19-9 levels was evaluated. Chest CT revealed nodular bronchiectasis without cavitation in most patients (78.5%). Serum CA19-9 levels were elevated in 19 (24%) patients. Serum CA19-9 levels were positively correlated with the total CT score and bronchiectasis, bronchiolitis, cavity, and consolidation subscores. Partial correlation analysis revealed a significant positive correlation between serum CA19-9 levels and CT scores for total score and bronchiectasis, bronchiolitis, cavitation, and consolidation subscores after controlling for age, sex, and BMI. Serum CA19-9 levels were positively correlated with the CT severity score for NTM-PD. Serum CA19-9 may be useful in evaluating disease activity or therapeutic response in patients with NTM-PD.

Simple cholangitis induces extremely and recurrently elevated serum carbohydrate antigen 19-9 level

2019 ◽  
Vol 18 (3) ◽  
pp. 294-295 ◽  
Author(s):  
Ding-Li Xu ◽  
Yi-Qun Wu ◽  
Chang Xin ◽  
Qi-Feng Zhou ◽  
Ming-Liang Chen ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Carbohydrate Antigen ◽  
Serum Carbohydrate Antigen

scholarly journals Serum Carbohydrate Antigen 199 as a Biomarker for Evaluating Patients with Choledocholithiasis

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Wang Gu ◽  
Zhong Tong
Keyword(s):  
Correlation Analysis ◽  
White Cell Count ◽  
Elevated Serum ◽  
Serum Levels ◽  
Carbohydrate Antigen ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Serum Carbohydrate Antigen ◽  
The Difference ◽  
White Blood Cell Counts

Aims. Choledocholithiasis is a common and yet potentially debilitating disease of the biliary tract. While certain patients with this disease remain largely asymptomatic or experience mild discomfort, in several cases, patient can suffer biliary inflammation and other serious symptoms. Previous studies have detected elevated serum levels of carbohydrate antigen 199 in patients with choledocholithiasis. We wanted to know whether serum CA199 level in patients with choledocholithiasis is related to the level of inflammation in patients. Methods. In the present study, we separated a cohort of 135 choledocholithiasis patients into two groups based on their white blood cell counts, which were either 3.5−9.5×109/L or ≥9.5×109/L. We also divided patients into two groups according to CPR < 10 mg/L and CRP ≥ 10 mg/L. At the same time, the correlation between CA199 and CRP level was analyzed. Results. We then used a Rank-sum test to compare serum carbohydrate 199 levels between these groups, revealing significantly higher levels of this antigen in patients with a white cell count ≥9.5×109/L (Z=−3.584, P<0.01). The two groups were grouped by CRP, and the CA199 level was compared. The difference between the two groups was statistically significant (P<0.01). The correlation analysis between CA199 and CRP showed an obvious correlation (r=0.574). Conclusion. This suggests that in patients with choledocholithiasis, higher circulating carbohydrate antigen 199 levels may correspond to a higher degree of inflammation.

scholarly journals CORRELATION BETWEEN CHEST COMPUTED TOMOGRAPHY AND LUNG ULTRASONOGRAPHY IN PATIENTS WITH CORONAVIRUS DISEASE 2019 (COVID-19)

2020 ◽  
Author(s):  
Yale Tung-Chen ◽  
Milagros Martí de Gracia ◽  
Aurea Díez-Tascón ◽  
Sergio Agudo-Fernández ◽  
Rodrigo Alonso-González ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positive Predictive Value ◽  
Ct Scan ◽  
Severity Score ◽  
Chest Ct ◽  
Lung Ultrasonography ◽  
Rt Pcr ◽  
Lung Abnormalities ◽  
Missed Diagnosis ◽  
Similar Accuracy

ABSTRACTINTRODUCTIONThere is growing evidence regarding the imaging findings of Coronavirus Disease 2019 (COVID-19), in chest X-ray and Computed Tomography scan (CT). At this moment, the role of Lung Ultrasonography (LUS) has yet to be explored.OBJECTIVESThe main purpose of this study is to evaluate the correlation between LUS findings and chest CT in confirmed (positive RT-PCR) or clinically highly suspicious (dyspnea, fever, myasthenia, gastrointestinal symptoms, dry cough, ageusia or anosmia) of COVID-19 patients.METHODSProspective study carried out in the emergency department (ED) of confirmed or clinically highly suspicious COVID-19 patients who were subjected to a chest CT and concurrent LUS exam. An experienced ED physician performed the LUS exam blind to the clinical history and results of the CT scan, which were reviewed by two radiologists in consensus for signs compatible with COVID-19 (bilateral ground-glass opacities in peripheral distribution). Compatible LUS exam was considered a bilateral pattern of B-lines, irregular pleural line and subpleural consolidations.RESULTSBetween March and April 2020, fifty-one patients were consecutively enrolled. The indication for CT was a negative or indeterminate RT-PCR test (49.0%) followed by suspicion of pulmonary embolism (41.2%). Radiological signs compatible with COVID-19 were present in thirty-seven patients (72.5%) on CT scan and forty patients (78.4%) on LUS exam. The presence of LUS findings was correlated with a positive CT scan suggestive of COVID-19 (OR: 13.3, 95%CI: 4.539.6, p<0.001) with a sensitivity of 100.0% and a specificity of 78.6%, positive predictive value of 92.5% and negative of 100.0%. There was no missed diagnosis of COVID-19 with LUS compared to CT in our cohort. The LUS Score had a good correlation with CT total severity score (ICC 0.803, 95% CI 0.60-0.90, p<0.001).CONCLUSIONLUS presents similar accuracy compared to chest CT to detect lung abnormalities in COVID-19 patients.Summary StatementLUS presents similar accuracy compared to chest CT to detect lung abnormalities in COVID-19 patients.Key Results-Common LUS findings mirror those previously described for CT: bilateral, peripheral, consolidation and/or ground glass opacities.-LUS findings correlated with CT scan with a sensitivity of 100.0% and a specificity of 78.6%, positive predictive value of 92.5% and negative of 100.0%. The Lung score had a good correlation with CT total severity score (ICC 0.803, 95% CI 0.601-0.903, p < 0.001).-There were no missed diagnosis of COVID-19 with LUS compared to CT in our cohort.

scholarly journals Mediastinal mature teratoma with elevated serum carbohydrate antigen 19-9 levels

2008 ◽  
Vol 22 (4) ◽  
pp. 701-704
Author(s):  
Shinji Hirai ◽  
Yoshiharu Hamanaka ◽  
Norimasa Mitsui ◽  
Shinnosuke Uegami ◽  
Yousuke Matsuura
Keyword(s):  
Mature Teratoma ◽  
Elevated Serum ◽  
Carbohydrate Antigen ◽  
Serum Carbohydrate Antigen

scholarly journals Diagnostic Accuracy of Serum Carbohydrate Antigen 19-9 in Determining Etiology of Obstructive Jaundice

2017 ◽  
Vol 7 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Rokanuzzaman Bhuyian ◽  
Mohammad Golam Azam ◽  
Md Abdur Rob ◽  
Tareq M Bhuiyan ◽  
Md Anisur Rahman
Keyword(s):  
Obstructive Jaundice ◽  
Diagnostic Accuracy ◽  
Biliary Drainage ◽  
Elevated Serum ◽  
Tumour Marker ◽  
Carbohydrate Antigen ◽  
Morphological Findings ◽  
Serum Carbohydrate Antigen ◽  
Sensitivity Specificity ◽  
Hepatobiliary Tract

Background: Serum carbohydrate antigen 19-9 (CA 19-9), a tumour marker for malignancies of the hepatobiliary tract and pancreas, frequently elevated in a number of non-malignant conditions that are associated with jaundice. The CA 19-9 tends to normalize following the restoration of biliary drainage. This study was designed to assess the clinical application of CA19-9 in diagnosing pancreatobiliary malignancies in patients with obstructive jaundice and in discriminating between benign and malignant causes.Methods: Sixty three patients presented with obstructive jaundice on the basis of clinical, biochemical and imaging methods with elevated CA 19-9 were included in this study. Serum CA 19-9 levels were measured on admission and two weeks following endoscopic biliary drainage performed through an ERCP procedure at the department of Gastrointestinal, hepatobiliary and pancreatic disorders (GHPD) of BIRDEM general hospital. Malignant and benign cases were differentiated by ultrasonogram, CT scan, MRCP and morphological findings during ERCP procedure. Diagnostic accuracy of CA19-9 in the detection of malignancy was estimated by the receiver operating characteristic (ROC) curve.Results: Age was 53.76±14.48 years (mean±SD) and sex was 32:31 (M:F). Median value of CA 19-9 in malignant cases was higher (1000 U/ml) than benign cases (93 U/ml) (p=0.001). After biliary drainage serum CA19-9 levels normalized in 15(50%) benign and 1(3%) malignant cases (p=0.001). The AUC of CA 19-9 was 0.825. Sensitivity, specificity, PPV and NPV at cut off value 90 U/ml were 100, 50, 68.8 and 100; at 100 U/ml were 100, 53.3, 70.2 and 100; at 200 U/ml were 90.9, 66.7, 75 and 87, at 500 U/ml were 63.6, 76.7,75 and 65.7 respectively. Diagnostic accuracy of CA 19-9 was observed more at cut off value 200 U/ml.Conclusions: Deranged CA19-9 is frequently observed in benign conditions with jaundice and shown to normalize following improvement of biliary drainage. Caution is necessary in the interpretation of an elevated serum CA 19-9 value as a marker for malignancy, especially in patients with benign cholestasis.Birdem Med J 2017; 7(2): 95-100

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