S3229 Does Fecal Microbiota Transplantation Affect the Comorbidities Associated With Type 2 Diabetes Mellitus?

Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino acids, and lipopolysaccharide are the main molecules related to T2DM. Many studies have investigated the role of gut microbiota in T2DM, particularly those butyrate-producing bacteria. Increasing evidence has demonstrated that fecal microbiota transplantation and probiotic capsules are useful strategies in preventing diabetes. In this review, we aim to elucidate the complex association between gut microbiota and T2DM inflammation, metabolism, and immune disorders, the underlying mechanisms, and translational applications of gut microbiota. This review will provide novel insight into developing individualized therapy for T2DM patients based on gut microbiota immunometabolism.

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Prospects for the use of fecal microbiota transplantation in obese patients with Type 2 Diabetes Mellitus for weight loss and improvement of insulin sensitivity

Diabetes Mellitus ◽

10.14341/dm12716 ◽

2021 ◽

Vol 23 (6) ◽

pp. 541-547

Author(s):

E. V. Pokrovskaya ◽

I. A. Sklyanik ◽

E. A. Shestakova ◽

M. V. Shestakova

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Metabolic Diseases ◽

Fecal Microbiota Transplantation ◽

Fecal Microbiota ◽

Fecal Microflora ◽

Prevention And Treatment ◽

The Moment

Concerning the uncontrolled growth in the incidence of obesity and Type 2 Diabetes Mellitus (T2DM), numerous research have been carried out to study the pathogenetic mechanisms of progress of these diseases and development of new methods for their prevention and treatment in recent years. T2DM is known to be a multifactorial disease, in the development of which both lifestyle and various environmental factors, and genetic predisposition are involved. At the same time, in recent years, a theory has been discussed that intestinal dysbiosis, which is caused with quantitative and qualitative changes in the gut microbiota (GM) is one of the mechanisms of obesity and T2DM development. At the moment, various methods have been proposed for restoring the normal composition of GM, including the administration of prebiotics and metabiotics that stimulate the growth of gut flora, as well as probiotics, which directly include the necessary beneficial bacteria (mainly Bifidobacterium and Lactobacillus). Fecal microflora transplantation (FMT), which allows transferring an entire microbial community into the recipient's body, rather than individual bacteria is the newest and least studied method of GM normalization. In this connection, this method of GM influencing is of great interest for the prevention and treatment of metabolic diseases.

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Sa1928 A 24-WEEK, DOUBLE-BLIND, RANDOMIZED TRIAL OF FECAL MICROBIOTA TRANSPLANTATION ON MICROBIAL ACQUISITION IN OBESE PATIENTS WITH TYPE 2 DIABETES MELLITUS

Gastroenterology ◽

10.1016/s0016-5085(20)31886-2 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-483-S-484

Author(s):

Zhilu XU ◽

Keli Yang ◽

Qin Liu ◽

Whitney Tang ◽

Tao Zuo ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Randomized Trial ◽

Fecal Microbiota Transplantation ◽

Fecal Microbiota ◽

Obese Patients ◽

Double Blind

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Is fecal microbiota transplantation a promising strategy for type 2 diabetes mellitus?

Endocrinology&Metabolism International Journal ◽

10.15406/emij.2020.08.00275 ◽

2020 ◽

Vol 8 (2) ◽

Author(s):

Zhongping Yang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Fecal Microbiota Transplantation ◽

Fecal Microbiota ◽

Promising Strategy

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Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects

Nutrients ◽

10.3390/nu12102996 ◽

2020 ◽

Vol 12 (10) ◽

pp. 2996

Author(s):

Tomohisa Takagi ◽

Yuji Naito ◽

Saori Kashiwagi ◽

Kazuhiko Uchiyama ◽

Katsura Mizushima ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Gut Microbiota ◽

Fecal Microbiota ◽

Metabolic Enzyme ◽

Α Diversity ◽

Significant Difference ◽

Japanese Subjects

The human gut microbiota is involved in host health and disease development. Therefore, lifestyle-related diseases such as hypertension (HT), hyperlipidemia (HL), and type 2 diabetes mellitus (T2D) may alter the composition of gut microbiota. Here, we investigated gut microbiota changes related to these diseases and their coexistence. This study involved 239 Japanese subjects, including healthy controls (HC). The fecal microbiota was analyzed through the isolation of bacterial genomic DNA obtained from fecal samples. Although there were no significant differences in the microbial structure between groups, there was a significant difference in the α-diversity between HC and the patients in whom two diseases coexisted. Moreover, Actinobacteria levels were significantly increased, whereas Bacteroidetes levels were significantly decreased in all disease groups. At the genus level, Bifidobacterium levels were significantly increased in the HL and T2D groups, as were those of Collinsella in all disease groups. In contrast, Alistipes levels were significantly lower in the HL group. Furthermore, metabolic enzyme families were significantly increased in all disease groups. Interestingly, the structure and function of the gut microbiota showed similar profiles in all the studied diseases. In conclusion, several changes in the structure of the gut microbiota are associated with T2D, HT, and HL in Japanese subjects.

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