scholarly journals PTCOG Head and Neck Subcommittee Consensus Guidelines on Particle Therapy for the Management of Head and Neck Tumors

2021 ◽  
Vol 8 (1) ◽  
pp. 84-94
Author(s):  
Alexander Lin ◽  
John H. C. Chang ◽  
Ryan S. Grover ◽  
Frank J. P. Hoebers ◽  
Upendra Parvathaneni ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Side Effects ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Clinical Evidence ◽  
Particle Therapy ◽  
Future Research ◽  
Consensus Guidelines ◽  
Normal Tissues

Abstract Purpose: Radiation therapy is a standard modality in the treatment for cancers of the head and neck, but is associated with significant short- and long-term side effects. Proton therapy, with its unique physical characteristics, can deliver less dose to normal tissues, resulting in fewer side effects. Proton therapy is currently being used for the treatment of head and neck cancer, with increasing clinical evidence supporting its use. However, barriers to wider adoption include access, cost, and the need for higher-level evidence. Methods: The clinical evidence for the use of proton therapy in the treatment of head and neck cancer are reviewed here, including indications, advantages, and challenges. Results: The Particle Therapy Cooperative Group Head and Neck Subcommittee task group provides consensus guidelines for the use of proton therapy for head and neck cancer. Conclusion: This report can be used as a guide for clinical use, to understand clinical trials, and to inform future research efforts.

scholarly journals EP-1542: Can proton therapy for head and neck cancer reduce side effects while maintaining target robustness?

2017 ◽  
Vol 123 ◽  
pp. S829
Author(s):  
D. Scandurra ◽  
R.G.J. Kierkels ◽  
M. Gelderman ◽  
H.M. Credoe ◽  
H.P. Bijl ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Side Effects ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy

Proton therapy for head and neck cancer: Rationale, potential indications, practical considerations, and current clinical evidence

2011 ◽  
Vol 50 (6) ◽  
pp. 763-771 ◽  
Author(s):  
Nancy P. Mendenhall ◽  
Robert S. Malyapa ◽  
Zhong Su ◽  
Daniel Yeung ◽  
William M. Mendenhall ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Clinical Evidence

scholarly journals Methodologies to Increase the Level of Evidence of Real-life Proton Therapy in Head and Neck Tumors

2021 ◽  
Vol 8 (1) ◽  
pp. 328-338
Author(s):  
Francesco Dionisi ◽  
Lamberto Widesott ◽  
Marco Van Vulpen ◽  
Clifton David Fuller ◽  
Rocco Frondizi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Clinical Evidence ◽  
Randomized Clinical Trials ◽  
Real Life ◽  
Level Of Evidence ◽  
Neck Tumors ◽  
New Methodologies

Abstract This review aims to present and assess available and new methodologies to increase the clinical evidence of proton therapy data for patients with head and neck cancer. Despite the increasing number of scientific reports showing the feasibility and effectiveness of proton therapy in head and neck cancer, clinical evidence on the potential benefits of its use remains low for several reasons. In this article, the pros and cons of consolidated and new methodologies in this setting such as randomized clinical trials, the model-based approach, and the use of prospective multicentric registries will be detailed.

scholarly journals Preselection Tool for the Model-Based Selection of Head and Neck Cancer Patients for Proton Therapy

2019 ◽  
Vol 105 (1) ◽  
pp. E384
Author(s):  
M. Tambas ◽  
H.P. van der Laan ◽  
A.V.D. Hoek ◽  
H.P. Bijl ◽  
M. Dieters ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Model Based ◽  
Selection Of

Reirradiation of Recurrent and Second Primary Head and Neck Cancer With Proton Therapy

2016 ◽  
Vol 96 (4) ◽  
pp. 808-819 ◽  
Author(s):  
Mark W. McDonald ◽  
Omid Zolali-Meybodi ◽  
Stephen J. Lehnert ◽  
Neil C. Estabrook ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Second Primary

scholarly journals Insurance Approval for Proton Therapy for Head and Neck Cancer: One Cancer Centers Experience

2018 ◽  
Vol 102 (3) ◽  
pp. e413
Author(s):  
M.S. Ning ◽  
D.R. Gomez ◽  
E.D. Brooks ◽  
C. Kim ◽  
M.B. Palmer ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Cancer Centers ◽  
Insurance Approval

The EORTC randomized trial on three fractions per day and misonidazole (trial no. 22811) in advanced head and neck cancer: long-term results and side effects

1995 ◽  
Vol 35 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Walter Van den Bogaert ◽  
Emmanuel van der Schueren ◽  
Jean-Claude Horiot ◽  
Mario De Vilhena ◽  
Simon Schraub ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Side Effects ◽  
Randomized Trial ◽  
Head And Neck ◽  
Neck Cancer ◽  
Long Term Results ◽  
Advanced Head

Proton Therapy for Head and Neck Cancer

2018 ◽  
Vol 19 (6) ◽  
Author(s):  
Joseph K. Kim ◽  
Jonathan E. Leeman ◽  
Nadeem Riaz ◽  
Sean McBride ◽  
Chiaojung Jillian Tsai ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy

scholarly journals Nanoparticle-Based Chemotherapy Formulations for Head and Neck Cancer: A Systematic Review and Perspectives

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1938
Author(s):  
Jefferson Muniz de Lima ◽  
Paulo Rogerio Bonan ◽  
Danyel Elias da Cruz Perez ◽  
Michael Hier ◽  
Moulay A. Alaoui-Jamali ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Side Effects ◽  
Head And Neck ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Basic Research ◽  
Cochrane Central Register ◽  
Level Of Evidence ◽  
Mortality And Morbidity

Head and neck cancer (HNC) is a complex and heterogeneous disease associated with high mortality and morbidity worldwide. Standard therapeutic management of advanced HNC, which is based on radiotherapy often combined with chemotherapy, has been hampered by severe long-term side effects. To overcome these side effects, tumor-selective nanoparticles have been exploited as a potential drug delivery system to improve HNC therapy. A combination of MEDLINE, EMBASE, Cochrane Oral Health Group’s Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov from inception up to June 2020 was used for this systematic review. A total of 1747 published manuscripts were reviewed and nine relevant references were retrieved for analysis, while eight of them were eligible for meta-analysis. Based on these studies, the level of evidence about the efficacy of nanoformulation for HNC therapy on tumor response and adverse side effects (SAE) was low. Even though basic research studies have revealed a greater promise of nanomaterial to improve the outcome of cancer therapy, none of them were translated into clinical benefits for HNC patients. This systematic review summarized and discussed the recent progress in the development of targeted nanoparticle approaches for HNC management, and open-up new avenues for future perspectives.

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