scholarly journals On pathogenesis of arterial hypertension in type 2 diabetes mellitus

2011 ◽  
Vol 14 (2) ◽  
pp. 53-55
Author(s):  
Violen Stepanovich Volkov ◽  
Evgenia Vladimirovna Rudenko ◽  
Svetlana Anatol'evna Rokkina ◽  
Olga Borisovna Poselyugina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Hypertension ◽  
Arterial Blood Flow ◽  
Circulation Rate ◽  
Arterial Blood ◽  
Mechanisms Of Development

Aim. To study the functional state of arterioles in patients with type 2 diabetes mellitus and concomitant arterial hypertension (AH) and evaluatethe role of sodium in mechanisms of elevation of arterial pressure (AP) in this pathology. Materials and methods. 163 patients of whom 83 had DM2 with AH and 80 essential hypertension. They were examined by dopplerography of themicrocirclatory bed, measurement of arterial blood flow and daily sodium urinary excretion. Results. Patients with essential AH showed increased arteriolar circulation rate and enhanced reactivity of microvessels. These parameters werereduced in patients with DM2 and AH who consumed large amount of table salt. Conclusion. Mechanisms of development of essential AH and AH in DM2 are significantly different.

scholarly journals Evaluation of liver function in acute complications of type 2 diabetes mellitus

2019 ◽  
Vol 6 (1) ◽  
pp. 118
Author(s):  
Periyasamy Sivakumar ◽  
Thiyagarajan Manjuladevi Moonishaa ◽  
Neethu George ◽  
Reena Savariraj
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liver Function ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Elevated Liver Enzymes ◽  
Acute Complications

Background: Diabetic ketoacidosis (DKA) and Hyperosmolar Hyperglycaemic state (HHS) are the acute complications of Type 2 Diabetes Mellitus (T2DM). The aim was to evaluate the role of liver function parameters in T2DM patients with DKA and HHS.Methods: This descriptive study included 50 subjects in each of the following four groups: non-T2DM, T2DM without acute complications, T2DM with DKA, T2DM with HHS. Data on demography, clinical and lab diagnosis, as well as liver function parameters were collected from May 2017 to October 2017. The baseline data and liver function parameters were compared across the study groups.Results: There was significant hyperglycemia and associated baseline electrolyte, Arterial Blood Gas (ABG) analysis changes in acute complications of T2DM. Besides GGT, the serum total and direct bilirubin levels were also higher in T2DM cases with DKA. Significant levels of hypoalbuminemia and hyperglobulinemia along with raised SGPT and ALP levels were seen in acute complications of T2DM, especially in HHS complicating T2DM.Conclusions: Decreased serum albumin levels, along with elevated liver enzymes-SGPT, ALP, and GGT characterized the acute complications of T2DM, with specific alterations of liver function parameters seen in DKA and HHS cases.

scholarly journals The role of inflammation in the development of metabolic disorders in patients with arterial hypertension

2019 ◽  
Vol 34 (3) ◽  
pp. 45-52
Author(s):  
L. V. Zhuravlyova ◽  
M. V. Kulikova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Hypertension ◽  
Metabolic Disorders ◽  
Developed Countries ◽  
The World ◽  
The Developed Countries

In recent years, the comorbid course of cardiovascular diseases, primarily arterial hypertension with impaired carbohydrate tolerance or type 2 diabetes mellitus, is becoming increasingly important in the developed countries of the world. In this regard, the need for a more detailed study of the general mechanisms of the development of arterial hypertension, pre-diabetes, and type 2 diabetes mellitus, namely inflammation, is increasing. There are many studies that investigate the role of inflammation in hypertension and associated glucometabolic disorders, but the exact mechanisms by which activated immune cells lead to the development and maintenance of these conditions remain to be seen. Obtaining new data in this area may contribute to a deeper understanding of cardiometabolic disorder pathogenesis. It may allow to predict the progression of these disorders at the early stages and to develop effective preventive and therapeutic tactics for their correction.

scholarly journals The role of the renin-angiotensin system gene polymorphisms in the development of carbohydrate disorders in patients with arterial hypertension

2019 ◽  
Vol 34 (3) ◽  
pp. 33-39
Author(s):  
L. V. Zhuravlyova ◽  
M. V. Kulikova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Hypertension ◽  
Gene Polymorphisms ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Arterial hypertension and type 2 diabetes mellitus are the most widespread comorbid pathologies. The coexistence of these disorders accelerates the development of micro- and macrovascular complications, considerably increases the cardiovascular risk, as well as the risk of stroke and end stage renal disease. The synergism of these two pathologies is caused by the unity of pathogenetic mechanisms. Genetic predisposition also contributes to the development of both pathologies. It is well known that blockade of the renin-angiotensin system slows down the development of type 2 diabetes mellitus and also reduces the frequency of cardiovascular or kidney events in patients with these disorders. Gene polymorphisms of the reninangiotensin system are thoughtfully studied in the context of cardiovascular disease development. Currently, the role of gene polymorphisms in the development of carbohydrate disorders is not established, however, there is a high probability of their influence and importance. The purpose of review is to analyze the accumulated data on the effects of the renin-angiotensin system gene polymorphisms on the development of arterial hypertension and type 2 diabetes mellitus.

scholarly journals Content of sP-selectin and Cytokines in Blood of Patients with Type 2 Diabetes Mellitus and Arterial Hypertension Depending on Diabetes Compensation Condition

2016 ◽  
Vol 8 (2) ◽  
pp. 123 ◽  
Author(s):  
A. M. Urbanovych ◽  
H. I. Suslyk ◽  
Kh. Yu. Kozlovska
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Hypertension ◽  
Blood Serum ◽  
Assay Method ◽  
Type 2 Dm ◽  
Tnf Α

<p>The goal of our research has been to study sР-selectin and cytokine content changes, namely ІL-2, ІL-6 and TNF-α in blood plasma of patients with type 2 diabetes mellitus with varying compensation for the disease and arterial hypertension, as well as to investigate a possible interrelation between sР-selectin and cytokines. To achieve the goal 137 patients with type 2 diabetes mellitus with AH of the І-ІІ stages and without AH (72 women and 65 men) have been examined. The levels of sР-selectin, ІL-2, ІL-6, TNF-a in blood serum were determined by means of immunoenzymatic assay method. As a result, a reliable increase in sP-selectin level in blood serum has been detected in patients with type 2 diabetes mellitus with deterioration of diabetes compensation along with АH; increase in ІL-6 level in groups with good and satisfactory compensation for diabetes and TNF -α in groups with bad compensation with the presence of АH.<em> </em>A reverse correlation between the content of sP-selectin and TNF-α in groups of those examined with non-compensated type 2 DM, associated with АH and without AH, stronger in a group of patients with type 2 DM and AH. The level of sP-selectin in blood increases with the deterioration of type 2 DM compensation along with AH. Most probable reverse correlations between sP-selectin and TNF-a levels in groups of patients with insufficient compensation for diabetes may indicate a mutually potential role of these factors in the development and progression of type 2 DM decompensation and AH.</p>

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