Content of sP-selectin and Cytokines in Blood of Patients with Type 2 Diabetes Mellitus and Arterial Hypertension Depending on Diabetes Compensation Condition

<p>The goal of our research has been to study sР-selectin and cytokine content changes, namely ІL-2, ІL-6 and TNF-α in blood plasma of patients with type 2 diabetes mellitus with varying compensation for the disease and arterial hypertension, as well as to investigate a possible interrelation between sР-selectin and cytokines. To achieve the goal 137 patients with type 2 diabetes mellitus with AH of the І-ІІ stages and without AH (72 women and 65 men) have been examined. The levels of sР-selectin, ІL-2, ІL-6, TNF-a in blood serum were determined by means of immunoenzymatic assay method. As a result, a reliable increase in sP-selectin level in blood serum has been detected in patients with type 2 diabetes mellitus with deterioration of diabetes compensation along with АH; increase in ІL-6 level in groups with good and satisfactory compensation for diabetes and TNF -α in groups with bad compensation with the presence of АH.<em> </em>A reverse correlation between the content of sP-selectin and TNF-α in groups of those examined with non-compensated type 2 DM, associated with АH and without AH, stronger in a group of patients with type 2 DM and AH. The level of sP-selectin in blood increases with the deterioration of type 2 DM compensation along with AH. Most probable reverse correlations between sP-selectin and TNF-a levels in groups of patients with insufficient compensation for diabetes may indicate a mutually potential role of these factors in the development and progression of type 2 DM decompensation and AH.</p>

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Role of CHA2DS2-VASc score in predicting new-onset atrial fibrillation in patients with type 2 diabetes mellitus with and without hyperosmolar hyperglycaemic state: real-world data from a nationwide cohort

BMJ Open ◽

10.1136/bmjopen-2017-020065 ◽

2018 ◽

Vol 8 (3) ◽

pp. e020065 ◽

Cited By ~ 2

Author(s):

Wei-Syun Hu ◽

Cheng-Li Lin

Keyword(s):

Diabetes Mellitus ◽

Atrial Fibrillation ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Predictive Ability ◽

Type 2 Dm ◽

History Of ◽

New Onset

PurposeThe objective of the current study was to explore the role of CHA2DS2-VASc score in predicting incidence of atrial fibrillation (AF) in patients with type 2 diabetes mellitus (DM). Furthermore, the use of the CHA2DS2-VASc score for stratifying new-onset AF risk in patients with DM and with/without hyperosmolar hyperglycaemic state (HHS) was also compared.MethodsThe study subjects were identified from Longitudinal Health Insurance Database provided by the National Health Research Institutes. The patients with DM were divided into two groups based on a history of HHS or not. The predictive ability of CHA2DS2-VASc score for stratifying new-onset AF risk in the two groups was calculated using the area under the curve of receiver-operating characteristic (AUROC).ResultsThe present study involved a total of 69 530 patients with type 2 DM. Among them, 1558 patients had a history of HHS, whereas 67 972 patients did not. The AUROC of the CHA2DS2-VASc score as a predictor of incident AF in patients with DM and with/without HHS was 0.67 (95% CI 0.59 to 0.75) and 0.71 (95% CI 0.70 to 0.72), respectively.ConclusionsTo conclude, we reported for the first time on the assessment of CHA2DS2-VASc score for incident AF risk discrimination in patients with type 2 DM. We further found that the predictive ability of the CHA2DS2-VASc score was attenuated in patients with type 2 DM and with HHS in comparison with those without HHS.

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The role of the sympathoadrenal system and adipokines in the development of arterial hypertension in type 2 diabetes mellitus and obesity

Obesity and metabolism ◽

10.14341/2071-8713-5050 ◽

2012 ◽

Vol 9 (1) ◽

pp. 14-18 ◽

Cited By ~ 1

Author(s):

A V Pashentseva

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Arterial Hypertension ◽

Sympathoadrenal System

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Effectiveness of atorvastatin therapy in patients with arterial hypertension, diabetic nephropathy and diabetes mellitus type 2

Likarska sprava ◽

10.31640/jvd.1-2.2019(15) ◽

2019 ◽

pp. 105-110

Author(s):

O. M. Chernatska ◽

T. S. Mazur ◽

N. V. Demikhova ◽

O. M. Vlasenko ◽

T. M. Rudenko ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Arterial Hypertension ◽

Lipid Profile ◽

Cardiovascular Complications ◽

Actual Problem ◽

Type 2 Dm

The actual problem of internal medicine is the managemen of patients with comorbid pathology. Arterial hypertension (AH) is determined in about quarter of the population in the world. Moreover, the coexistence of AH and type 2 diabetes mellitus (DM) connected with the increased risk of cardiovascular complications (CVC) compared with patients with AH. In principle dyslipidemia is the common link between AH and type 2 DM, which need the correction. No doubt that reduction of atherogenic and increase of anti atherogenic lipoproteins is necessary for persons with comorbid pathology. The objective of our study was the assessment of atorvastatin treatment in patients with AH, diabetic nephropathy and type 2 DM. We obtained 96 patients with AH, diabetic nephropathy and type 2 DM (І group), 25 persons with AH (ІІ group), 15 conditionally healthy individuals. Persons had CVC in the past. For patients from the І and ІІ group CVC were defined accordingly (4,97 ± 0,20) years and (4,10 ± 0,05) years ago (P = 0,0291). The duration of AH is (8,1 ± 0,2) years for the І group and (8,90 ± 0,13) years for the ІІ group. The levels of lipid profile spectrum were determined according to the methods of W. T. Friedewald. The results of investigation were analyzed with the help of Microsoft Excel 2016. Correction of lipid profile spectrum is the important part of multipurpose treatment for persons with coexistent pathology. All patients were treated by atorvastatin (10−40 mg/day) during 6 months in a complex therapy. The target levels of general cholesterol during 6 months were presented in 30 persons (31.91 %), low density lipoproteids – in 10 persons (10.64 %), high density lipoproteids – in 26 persons (27.66 %), triglycerides – in 34 persons (36.17 %) among patients with AH, diabetic nephropathy and type 2 DM. In conclusion, it is advisable to prescribe atorvastatin (10–40 mg/day) for correction of dyslipidemia, reduction of proatherogenic orientation, prevention of atherosclerotic process manifestation and cardiovascular complications in patients with AH with diabetic nephropathy and type 2 diabetes mellitus.

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Arterial hypertension and type 2 diabetes mellitus in patients with metabolic disorders: Their impact on the lipid spectrum

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2003-9-2-67-70 ◽

2003 ◽

Vol 9 (2) ◽

pp. 67-70 ◽

Cited By ~ 1

Author(s):

A. I. Kuzin ◽

M. A. Cherednikova ◽

A. A. Vasilyev ◽

O. V. Kamerer

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Arterial Hypertension ◽

Metabolic Disorders ◽

The Body ◽

Cholesterol Levels ◽

Type 2 Dm ◽

Lipid Spectrum

The study was undertaken to examine the specific features of the lipid spectrum in patients with metabolic disorders in the absence or presence of arterial hypertension (AH) and type 2 diabetes mellitus (DM) The study covered 176 patients with metabolic disorders, 138 patients were diagnosed as having AH, of them 39 patients had type 2 DM Clinical and laboratory studies involved the estimation of the body mass index, waist/hip ratio, and lipid spectrum All the patients were divided into 3 groups I) 38 without AH and type 2 DM, 2) 99 with isolated AH without type 2 DM, 3) 39 with AH and type 2 DM The higher severity of abdominal obesity was associated with enhanced dyslipidemia atherogemcity The development of AH m the presence of metabolic disorders was accompanied by higher total cholesterol levels, which may be considered as aggravated endothelial dysfunction Its concurrence with type 2 DM was attended by transformation of metabolic to diabetic dyslipidemia The study has yielded a new index that characterizes dyslipidemia atherogemcity in patients with metabolic disorders

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On pathogenesis of arterial hypertension in type 2 diabetes mellitus

Diabetes Mellitus ◽

10.14341/2072-0351-5635 ◽

2011 ◽

Vol 14 (2) ◽

pp. 53-55

Author(s):

Violen Stepanovich Volkov ◽

Evgenia Vladimirovna Rudenko ◽

Svetlana Anatol'evna Rokkina ◽

Olga Borisovna Poselyugina

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Arterial Hypertension ◽

Arterial Blood Flow ◽

Circulation Rate ◽

Arterial Blood ◽

Mechanisms Of Development

Aim. To study the functional state of arterioles in patients with type 2 diabetes mellitus and concomitant arterial hypertension (AH) and evaluatethe role of sodium in mechanisms of elevation of arterial pressure (AP) in this pathology. Materials and methods. 163 patients of whom 83 had DM2 with AH and 80 essential hypertension. They were examined by dopplerography of themicrocirclatory bed, measurement of arterial blood flow and daily sodium urinary excretion. Results. Patients with essential AH showed increased arteriolar circulation rate and enhanced reactivity of microvessels. These parameters werereduced in patients with DM2 and AH who consumed large amount of table salt. Conclusion. Mechanisms of development of essential AH and AH in DM2 are significantly different.

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The role of inflammation in the development of metabolic disorders in patients with arterial hypertension

Siberian Medical Journal ◽

10.29001/2073-8552-2019-34-3-45-52 ◽

2019 ◽

Vol 34 (3) ◽

pp. 45-52

Author(s):

L. V. Zhuravlyova ◽

M. V. Kulikova

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Arterial Hypertension ◽

Metabolic Disorders ◽

Developed Countries ◽

The World ◽

The Developed Countries

In recent years, the comorbid course of cardiovascular diseases, primarily arterial hypertension with impaired carbohydrate tolerance or type 2 diabetes mellitus, is becoming increasingly important in the developed countries of the world. In this regard, the need for a more detailed study of the general mechanisms of the development of arterial hypertension, pre-diabetes, and type 2 diabetes mellitus, namely inflammation, is increasing. There are many studies that investigate the role of inflammation in hypertension and associated glucometabolic disorders, but the exact mechanisms by which activated immune cells lead to the development and maintenance of these conditions remain to be seen. Obtaining new data in this area may contribute to a deeper understanding of cardiometabolic disorder pathogenesis. It may allow to predict the progression of these disorders at the early stages and to develop effective preventive and therapeutic tactics for their correction.

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The role of the renin-angiotensin system gene polymorphisms in the development of carbohydrate disorders in patients with arterial hypertension

Siberian Medical Journal ◽

10.29001/2073-8552-2019-34-3-33-39 ◽

2019 ◽

Vol 34 (3) ◽

pp. 33-39

Author(s):

L. V. Zhuravlyova ◽

M. V. Kulikova

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Arterial Hypertension ◽

Gene Polymorphisms ◽

Renin Angiotensin System ◽

Angiotensin System ◽

Renin Angiotensin

Arterial hypertension and type 2 diabetes mellitus are the most widespread comorbid pathologies. The coexistence of these disorders accelerates the development of micro- and macrovascular complications, considerably increases the cardiovascular risk, as well as the risk of stroke and end stage renal disease. The synergism of these two pathologies is caused by the unity of pathogenetic mechanisms. Genetic predisposition also contributes to the development of both pathologies. It is well known that blockade of the renin-angiotensin system slows down the development of type 2 diabetes mellitus and also reduces the frequency of cardiovascular or kidney events in patients with these disorders. Gene polymorphisms of the reninangiotensin system are thoughtfully studied in the context of cardiovascular disease development. Currently, the role of gene polymorphisms in the development of carbohydrate disorders is not established, however, there is a high probability of their influence and importance. The purpose of review is to analyze the accumulated data on the effects of the renin-angiotensin system gene polymorphisms on the development of arterial hypertension and type 2 diabetes mellitus.

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Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy

Journal of Ophthalmology ◽

10.1155/2019/1825819 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Elena Garcia-Martin ◽

Marta Cipres ◽

Isabel Melchor ◽

Laura Gil-Arribas ◽

Elisa Vilades ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Disease Duration ◽

Vascular Complications ◽

Rnfl Thickness ◽

Type 2 Dm

Purpose. To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made. Results. Macular GCL was reduced in patients compared to controls (p<0.001). Differences in the macular RNFL thickness were only observed in the outer inferior sector (p=0.033). A reduction in the peripapillary RNFL (average, inferior, and inferotemporal thickness, p<0.05 for all three) was observed in patients using both applications. Patients with chronic systemic vascular complications presented a reduction in the temporal RNFL (p=0.019) compared to patients without complications. The superotemporal RNFL thickness was thinner in patients with longer disease duration. Conclusions. Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc. Systemic vascular complications contributed to further axonal damage in these patients, suggesting a possible role of subclinical ischaemia to retinal neurodegeneration in type 2 DM.

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