scholarly journals Prospects in the treatment of diabetic nephropathy

2019 ◽  
Vol 43 (3) ◽  
pp. 20-22
Author(s):  
M. V. Shestakova ◽  
A. V. Vorontsov ◽  
S. G. Vykhristyuk ◽  
I. I. Dedov
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Angiotensin Converting Enzyme ◽  
Vascular Endothelium ◽  
Structural Changes ◽  
Vascular Complications ◽  
Converting Enzyme ◽  
Treatment And Prevention ◽  
Vasoactive Factors ◽  
Triggering Factor

The authors discuss new approaches to the treatment and prevention of diabetic nephropathy based on elimination of the pathogenetic factors of its development. Hyperglycemia, the main triggering factor of vascular complications of diabetes mellitus. induces a cascade of other pathological reactions, such as renal dysfunction, biochemical and structural changes in the basal membranes of renal capillaries, and stimulates the secretion of vasoactive factors of vascular endothelium and platelets. Blocking of these reactions by specific agents inhibits the progress of diabetic nephropathy. The authors share their experience gained in the treatment of diabetic nephropathy with inhibitors of angiotensin-converting enzyme, glycosaminoglycanes, and thromboxane synthesis inhibitors. These drugs are more effective if prescribed at the early stages of diabetic involvement of the kidneys.

scholarly journals Diabetic Nephropathy Induced by IncreasedAceGene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Nádia Bertoncello ◽  
Roseli Peres Moreira ◽  
Danielle Yuri Arita ◽  
Danielle S. Aragão ◽  
Ingrid Kazue Mizuno Watanabe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Angiotensin Converting Enzyme ◽  
Renal Dysfunction ◽  
Population Studies ◽  
Structure And Function ◽  
Diabetic Group ◽  
Ang Ii ◽  
Converting Enzyme ◽  
And Function

Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACEin humans,Acein mice). The aim was to evaluate the modulation ofAcecopies number and diabetes mellitus (DM) on renal RAS and correlate it with indicators of kidney function. Increased number of copies of theAcegene, associated with DM, induces renal dysfunction. The susceptibility to the development of DN in 3 copies of animals is associated with an imbalance in activity of RAS enzymes leading to increased synthesis of Ang II and Ang-(1–7). Increased concentration of renal Ang-(1–7) appears to potentiate the deleterious effects triggered by Ang II on kidney structure and function. Results also show increased bradykinin concentration in 3 copies diabetic group. Taken together, results indicate that the deleterious effects described in 3 copies diabetic group are, at least in part, due to a combination of factors not usually described in the literature. Thus, the data presented here show up innovative and contribute to understanding the complex mechanisms involved in the development of DN, in order to optimize the treatment of patients with this complication.

Angiotensin-Converting Enzyme Polymorphism and Development of Diabetic Nephropathy in Non-Insulin-Dependent Diabetes mellitus

Nephron ◽  
1995 ◽  
Vol 70 (4) ◽  
pp. 455-459 ◽  
Author(s):  
Sonoo Mizuiri ◽  
Hiromichi Hemmi ◽  
Akira Inoue ◽  
Hiroko Yoshikawa ◽  
Masateru Tanegashima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Angiotensin Converting Enzyme ◽  
Insulin Dependent Diabetes Mellitus ◽  
Enzyme Polymorphism ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Converting Enzyme ◽  
Insulin Dependent

scholarly journals Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus

2016 ◽  
Vol 19 (2) ◽  
pp. 29-34 ◽  
Author(s):  
M Šeruga ◽  
J Makuc ◽  
M Završnik ◽  
I Cilenšek ◽  
R Ekart ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Angiotensin Converting Enzyme ◽  
Renal Disease ◽  
Cystatin C ◽  
Converting Enzyme ◽  
Standard Polymerase Chain Reaction

Abstract Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the development and progression of DN. The renin-angiotensin system was demonstrated to be involved in the development of DN. We evaluated the association between rs4340 of the angiotensin-converting enzyme (ACE) gene and DN in Caucasians with type 2 diabetes mellitus (T2DM) in 276 Slovenian patients with T2DM who had DN, and 375 patients without clinical signs of DN. Genetic analysis was performed with either standard polymerase chain reaction (PCR) (for rs4340). Results were analyzed using the χ2 test and multivariate logistic regression analyses. We found no association between rs4340 and DN. Cystatin C was significantly higher in the DN+ group (p <0.001) than in the DN group. Cystatin C was a better marker for the estimation of renal function than estimated glomerular filtration rate (eGFR) according to the modification diet in renal disease (MDRD) equation mL/ min. We concluded that there was no association between the rs4340 of the ACE gene and DN in Caucasian patients who have T2DM.

DD genotype of angiotensin-converting enzyme in type 2 diabetes mellitus with renal disease in Mexican Mestizos

Nephrology ◽  
2009 ◽  
Vol 14 (2) ◽  
pp. 235-239 ◽  
Author(s):  
SILVIA PALOMO-PIÑÓN ◽  
MARGARITA E GUTIÉRREZ-RODRÍGUEZ ◽  
MARGARITA DÍAZ-FLORES ◽  
REYNA SÁNCHEZ-BARRERA ◽  
ADÁN VALLADARES-SALGADO ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Angiotensin Converting Enzyme ◽  
Renal Disease ◽  
Converting Enzyme ◽  
Mexican Mestizos

The presence of allele D of angiotensin-converting enzyme polymorphism is associated with diabetic nephropathy in patients with less than 10 years duration of Type 2 diabetes

2005 ◽  
Vol 22 (9) ◽  
pp. 1167-1172 ◽  
Author(s):  
L. H. Canani ◽  
L. A. Costa ◽  
D. Crispim ◽  
K. Goncalves dos Santos ◽  
I. Roisenberg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Polymorphism ◽  
Converting Enzyme
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