The state of the guanylate cyclase mechanism of vasodilatation before and after thyroidectomy in the patients presenting with toxic goiter

2014 ◽  
Vol 60 (3) ◽  
pp. 15-22
Author(s):  
E A Ilyicheva ◽  
I F Tarnueva ◽  
Yu I Pivovarov ◽  
L B Koryakina ◽  
E A Chizhova
Keyword(s):  
Guanylate Cyclase ◽  
Brachial Artery ◽  
Vascular Endothelium ◽  
The State ◽  
Cyclase Activity ◽  
Guanylate Cyclase Activity ◽  
Before And After ◽  
Toxic Goiter

The state of the guanylate cyclase activity of myocytes was evaluated from the increment in the diameter of the brachial artery in response to the exogenous administration of nitroglycerin (#D^NO) in 64 samples obtained from 44 patients. A total of 23 studies were carried out during thyrotoxicosis decompensation, 28 ones in the phase of medicamental thyrotoxicosis, and 13 within 5-6 days after thyroidectomy. The guanylate cyclase activity of myocytes was found to correlate with the production of vascular endothelium factors. Thyroidectomy in the patients with toxic goiter and reduced guanylate cyclase activity of myocytes was associated with the statistically significant increase of endothelium-independent vasodilatation.

Guanylate Cyclase Activity in Normal and Neoplastic Squamous Epithelia from the Upper Aero-Digestive Tract

ORL ◽  
1986 ◽  
Vol 48 (5) ◽  
pp. 265-269
Author(s):  
E.L. Rydell ◽  
K.L. Axelsson ◽  
J. Olofsson ◽  
J.E.S. Wikberg
Keyword(s):  
Digestive Tract ◽  
Guanylate Cyclase ◽  
Cyclase Activity ◽  
Guanylate Cyclase Activity ◽  
Squamous Epithelia

scholarly journals Identification of a novel Arabidopsis thaliana nitric oxide-binding molecule with guanylate cyclase activity in vitro

FEBS Letters ◽  
2011 ◽  
Vol 585 (17) ◽  
pp. 2693-2697 ◽  
Author(s):  
Takalani Mulaudzi ◽  
Ndiko Ludidi ◽  
Oziniel Ruzvidzo ◽  
Monique Morse ◽  
Nicolette Hendricks ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Arabidopsis Thaliana ◽  
Guanylate Cyclase ◽  
Cyclase Activity ◽  
Guanylate Cyclase Activity

scholarly journals Histochemistry of guanylate cyclase activity.

1995 ◽  
Vol 43 (12) ◽  
pp. 1235-1240 ◽  
Author(s):  
S Mehdizadeh ◽  
A O'Farrell ◽  
L Bitensky ◽  
J Weisz ◽  
J Alaghband-Zadeh ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Cyclase Activity ◽  
Lead Ions ◽  
Ammonium Citrate ◽  
Considerable Proportion ◽  
Guanosine Triphosphate ◽  
Guanylate Cyclase Activity ◽  
Metal Capture ◽  
Cryostat Sections ◽  
Sufficient Concentration

Guanylate cyclase liberates pyrophosphate from guanosine triphosphate (GTP). In studies published previously, this phosphate is trapped by lead ions even though it is known that free lead ions inactivate a considerable proportion of this enzymatic activity. To overcome the damaging effects of fixation, this study used fresh cryostat sections stabilized with a sufficient concentration of a collagen-derived polypeptide to ensure no measurable loss of guanylate cyclase activity. To avoid the damaging influence of free lead ions, we used a hidden metal capture reagent, i.e., a complex of lead ammonium citrate/acetate that does not react with GTP but which rapidly forms a precipitate with the pyrophosphate liberated by the enzyme. The lead precipitate is then converted into the colored sulfide which is measured in individual cells by microdensitometry. This system was used to measure guanylate cyclase activity in individual cells in unfixed sections of rat liver.

scholarly journals Methylprednisolone stimulation of guanylate cyclase activity in rat ileal mucosa

1978 ◽  
Vol 74 (5) ◽  
pp. 1062 ◽  
Author(s):  
W.G. Marnane ◽  
A.N. Charney ◽  
E.C. Boedeker ◽  
M. Donowitz
Keyword(s):  
Guanylate Cyclase ◽  
Cyclase Activity ◽  
Ileal Mucosa ◽  
Guanylate Cyclase Activity ◽  
Stimulation Of
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