The purpose of this study was to examine the effect of plasma treatment by treating the surface of Co–Cr alloy, Ti–6Al–4V alloy, and CP–Ti alloy as a material for denture metal frameworks with non-thermal atmospheric pressure plasma (NTAPP) and measuring their
shear bond strength (SBS) with a heat-cured resin. 20 specimens were prepared for each of Co–Cr, Ti–6Al–4V, and CP–Ti alloys. Each metal alloy group was divided into the following subgroups depending on NTAPP treatment: C (Co–Cr alloy without plasma), T (CP–Ti
without plasma), A (Ti–6Al–4V alloy without plasma), CP (Co–Cr alloy with plasma), TP (CP–Ti with plasma) and AP (Ti–6Al–4V alloy with plasma). Specimens were treated with a metal conditioner and bonded to a denture base resin. SBS was measured using a universal
testing machine. All data obtained were statistically analyzed using two-way analysis of variance (ANOVA), Tukey’s honestly significant difference (HSD) test, and independent t-test. The mean values (SD) of SBS (MPa) were: 10.31 (1.19) for C group; 12.43 (0.98) for T group; 13.75
(2.02) for A group; 13.53 (1.61) for CP group; 16.87 (1.55) for TP group; 17.46 (1.65) for AP group. The SBS of the AP group was the highest while that of the C group was the lowest. SBS of specimen treated with NTAPP was significantly increased regardless of metal alloy types (p <
0.001). Within the limitations of this study, NTAPP can increases the SBS of Co–Cr alloy, CP–Ti alloy, and Ti–6Al–4V alloy with a denture base resin.