Denture Acrylic Resin Material with Antibacterial and Protein-Repelling Properties for the Prevention of Denture Stomatitis

Denture stomatitis is a multifactorial pathological condition of the oral mucosa that affects up to 72% of denture wearers. It is commonly seen on the palatal mucosa and characterized by erythema on the oral mucosa that are in contact with the denture surface. The aim of this study was to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) and dimethylaminohexadecyl methacrylate (DMAHDM) into a high impact polymethylmethacrylate heat-cured denture base acrylic resin as a potential treatment for denture stomatitis. We used a comparative study design to examine the effect of incorporating MPC as a protein repellent agent and DMAHDM as an antifungal agent to prevent the adherence of Candida albicans to the denture base material. The dual incorporation of MPC and DMAHDM reduced C. albicans biofilm colony-forming unit by two orders of magnitude when compared to the control group devoid of the bioactive agents. Although the addition of MPC and DMAHDM alone or in combination significantly reduced the flexural strength of the material, they showed reduced roughness values when compared to control groups. This new denture acrylic resin provides the benefit of enhancing C. albicans biofilm elimination through dual mechanisms of action, which could potentially reduce the prevalence of denture stomatitis.

Antimicrobial efficacy and biocompatibility of extracts from Cryptocarya species

This study evaluated the efficacy of Cryptocarya spp extracts on biofilm of Candida albicans and its biocompatibility. Mature biofilm of C. albicans was formed on denture base acrylic resin samples and the fungicidal effect of the extracts was evaluated by Alamar Blue® assay, counting colony-forming units (CFU/mL) and confocal laser scanning microscopy (CLSM). Cytotoxicity of extracts from Cryptocarya species was evaluated by AlamarBlue® assay, using normal oral keratinocytes (NOK) cells. In additional, Analysis of plant extracts by ultra-high-performance liquid chromatography–diode array detector–tandem mass spectrometry (UPLC-DAD-MS) was performed. The results showed significant reduction in the cellular metabolism and in the number of CFU/mL of C. albicans (p<0.05). The concentration of 0.045 g/mL completely inhibited the number of CFU/mL. Regarding cytotoxicity, all extracts decreased cell viability compared to the control group. CLSM analysis showed predominance of live cells, but with a great difference between the groups. Antimicrobial activity of extracts from Cryptocarya on C. albicans biofilm was confirmed. However, all extracts showed toxicity on NOK cells.

CU-SIL DENTURE AS A TRANSITIONAL PROSTHESIS TO PRESERVE THE REMAINING NATURAL TEETH USING PERMANENT SILICONE LINER

The goal of modern dentistry is to be conservative, preserving teeth but also maintaining the stability of the remaining alveolar ridge and the periodontium's proprioceptive capabilities. Cu-sil denture is the simplest approach in the preservation of teeth and maintaining proprioception. It is a type of transitional denture that provides an alternative treatment plan for the patients willing to replace their missing teeth while retaining their remaining natural teeth. It gives potential psychological benefits to the patients by avoiding extractions. It's a tissue-bearing acrylic appliance with a soft viscoelastic wrap that clasps the neck of each dentition, sealing out food and water simultaneously protecting and splinting each remaining tooth from the rigid acrylic denture base. This case reports series describes chairside techniques to fabricate Cu-sil dentures in the usual dental set-up

The Effect of Sandblasting on Bond Strength of Soft Liners to Denture Base Resins: A Systematic Review and Meta-Analysis of In Vitro Studies

Objectives. This study aimed to evaluate the effect of sandblasting on the bond strength of denture base resin to soft liners. Materials and Methods. This report follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. PubMed, Embase, Cochrane, Scopus, and OpenGrey databases were searched for in vitro studies that compared sandblasting with no treatment in terms of the tensile, shear, and peel bond strength of resilient lining materials (acrylic-based or silicone-based) to polymethyl methacrylate denture base resin. Based on the outcome, the analysis was carried out in three groups of tensile, shear, and peel bond strength. Subgroup analysis was done for the effect of size of particles on sandblasting, blasting pressure, and type of soft liner whenever possible. Heterogeneity was evaluated among the studies, and meta-analysis was performed with random effect models ( p < .05 ). Results. After screening, 16 articles met the inclusion criteria for meta-analyses. No treatment showed significantly higher tensile ( p < 0.001 ) or peel ( p = 0.04 ) bond strength, although shear bond strength of sandblasted resin was significantly better ( p = 0.008 ). Results of subgroup analyses of particle size favored the control group in 50 µ Al2O3 particle size ( p < 0.001 ). In analyses of blasting pressure, the control group had significantly better tensile bond strength than specimens with blasting pressure ≤1 bar ( p < 0.001 ) while specimens with blasting pressure beyond 1 bar showed significantly more tensile strength than control group ( p = 0.03 ). In silicon-based liners, groups without any surface treatment had significantly higher tensile bond strength ( p < 0.001 ). Conclusion. According to the in vitro studies, sandblasting would not lead to significant increase in bond strength of soft liner to the denture base resin.