scholarly journals The Asymmetric Synthesis of (2S,3S)-3-N-tert-Butoxycarbonylamino-2-Hydroxy-4-Phenylbutanoic Acid: A Core Component of Protease Inhibitors

2021 ◽  
Vol 8 (2) ◽  
pp. 7-11
Author(s):  
Yoshifumi Yuasa
Keyword(s):  
Asymmetric Synthesis ◽  
Protease Inhibitors ◽  
Core Component

Green One-Pot Asymmetric Synthesis of Peptidomimetics via Sequential Organocatalyzed Aziridination and Passerini Multicomponent Reaction

Synthesis ◽  
2019 ◽  
Vol 52 (07) ◽  
pp. 1076-1086
Author(s):  
Deborah A. dos Santos ◽  
Allan R. da Silva ◽  
Javier Ellena ◽  
Cecilia C. P. da Silva ◽  
Marcio W. Paixão ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Protease Inhibitors ◽  
Multicomponent Reaction ◽  
Efficient Method ◽  
Cysteine Protease ◽  
Heterocyclic Compounds ◽  
Solvent Mixture ◽  
Cysteine Protease Inhibitors ◽  
One Pot ◽  
Sequential Reaction

Peptidomimetics containing an aziridine moiety have been reported as potent cysteine protease inhibitors. In this sense, the development of stereoselective and sustainable synthetic strategies to obtain three-membered N-heterocyclic compounds has gained importance in the last decades. In this work, an efficient method was designed to achieve highly functionalized aziridine peptidomimetics via a sequential reaction, which involves the organocatalytic aziridination of α,β-unsaturated aldehydes followed by the Passerini multicomponent reaction in an environmentally friendly solvent mixture (ethanol: water).

Asymmetric Synthesis of the C3α Fragment of 5,6-Dihydro-α-pyrone Nonpeptidic HIV-1 Protease Inhibitors

1999 ◽  
Vol 64 (13) ◽  
pp. 4980-4984 ◽  
Author(s):  
Donna L. Romero ◽  
Peter R. Manninen ◽  
Fusen Han ◽  
Arthur G. Romero
Keyword(s):  
Asymmetric Synthesis ◽  
Protease Inhibitors ◽  
Hiv 1

ChemInform Abstract: Asymmetric Synthesis of 1,2,3,4,5,6-Hexahydro-5-hydroxypyrimidin-2-ones as Potential HIV-Protease Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 30 (45) ◽  
pp. no-no
Author(s):  
Dieter Enders ◽  
Lars Wortmann ◽  
Barbara Duecker ◽  
Gerhard Raabe
Keyword(s):  
Asymmetric Synthesis ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

SEM of non-coated hepatocellular cytoskeleton of perfused livers

1984 ◽  
Vol 42 ◽  
pp. 306-307
Author(s):  
S.W. French ◽  
N.C. Benson ◽  
C. Davis-Scibienski
Keyword(s):  
Ambient Temperature ◽  
Critical Point ◽  
Protease Inhibitors ◽  
Metal Deposition ◽  
Heat Damage ◽  
Detergent Extraction ◽  
Cytoskeletal Elements ◽  
Triton X ◽  
Excised Tissue

Previous SEM studies of liver cytoskeletal elements have encountered technical difficulties such as variable metal coating and heat damage which occurs during metal deposition. The majority of studies involving evaluation of the cell cytoskeleton have been limited to cells which could be isolated, maintained in culture as a monolayer and thus easily extracted. Detergent extraction of excised tissue by immersion has often been unsatisfactory beyond the depth of several cells. These disadvantages have been avoided in the present study. Whole C3H mouse livers were perfused in situ with 0.5% Triton X-100 in a modified Jahn's buffer including protease inhibitors. Perfusion was continued for 1 to 2 hours at ambient temperature. The liver was then perfused with a 2% buffered gluteraldehyde solution. Liver samples including spontaneous tumors were then maintained in buffered gluteraldehyde for 2 hours. Samples were processed for SEM and TEM using the modified thicarbohydrazide procedure of Malich and Wilson, cryofractured, and critical point dried (CPD). Some samples were mechanically fractured after CPD.

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