Scaling up to study brca2: the zeppelin zebrafish mutant reveals a role for brca2 in embryonic development of kidney mesoderm

Live Confocal Analysis of Fertilization and Early Development

Microscopy and Microanalysis ◽

10.1017/s1431927600031135 ◽

2001 ◽

Vol 7 (S2) ◽

pp. 1012-1013

Author(s):

Uyen Tram ◽

William Sullivan

Keyword(s):

Drosophila Melanogaster ◽

Embryonic Development ◽

Real Time ◽

Early Development ◽

Fluorescent Probes ◽

Primary Defect ◽

Fluorescent Analysis ◽

Dynamic Event ◽

Enormous Amount ◽

Fluorescent Studies

Embryonic development is a dynamic event and is best studied in live animals in real time. Much of our knowledge of the early events of embryogenesis, however, comes from immunofluourescent analysis of fixed embryos. While these studies provide an enormous amount of information about the organization of different structures during development, they can give only a static glimpse of a very dynamic event. More recently real-time fluorescent studies of living embryos have become much more routine and have given new insights to how different structures and organelles (chromosomes, centrosomes, cytoskeleton, etc.) are coordinately regulated. This is in large part due to the development of commercially available fluorescent probes, GFP technology, and newly developed sensitive fluorescent microscopes. For example, live confocal fluorescent analysis proved essential in determining the primary defect in mutations that disrupt early nuclear divisions in Drosophila melanogaster. For organisms in which GPF transgenics is not available, fluorescent probes that label DNA, microtubules, and actin are available for microinjection.

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Wnt Signaling in Embryonic Development

10.1016/s1574-3349(06)x1700-3 ◽

2007 ◽

Keyword(s):

Embryonic Development ◽

Wnt Signaling

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International Research-Policy Collaborations for Scaling Up Sustainable Early Development Services

PsycEXTRA Dataset ◽

10.1037/e500102015-006 ◽

2014 ◽

Author(s):

Pia Rebello Britto ◽

Hirokazu Yoshikawa ◽

June Lee ◽

Julieta Trias

Keyword(s):

Early Development ◽

International Research ◽

Research Policy ◽

Scaling Up

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The Real Leap Forward: Scaling up Poverty Reduction in China

PsycEXTRA Dataset ◽

10.1037/e646182010-001 ◽

2004 ◽

Keyword(s):

Poverty Reduction ◽

Scaling Up ◽

The Real

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Scaling up: single organisms and metagenomics

PSI Structural Genomics Knowledgebase ◽

10.1038/fa_sbkb.2010.40 ◽

2010 ◽

Author(s):

Katrin Legg

Keyword(s):

Scaling Up

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ADHD therapy with methylphenidate in mothers – a danger for embryonic development?

Pharmacopsychiatry ◽

10.1055/s-0034-1386843 ◽

2014 ◽

Vol 47 (06) ◽

Author(s):

N Bergemann ◽

K Boyle ◽

WE Paulus

Keyword(s):

Embryonic Development

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Track 6.c Introduction: Entrepreneurship in Design Education

Conference Proceedings of the Academy for Design Innovation Management ◽

10.33114/adim.2019.6c ◽

2019 ◽

Vol 2 (1) ◽

Author(s):

Bryan Howell ◽

Curt Anderson ◽

Nile Hatch ◽

Chia-Chi TENG; ◽

Neal Bangerter ◽

...

Keyword(s):

Design Education ◽

Management Strategy ◽

Business Models ◽

Scaling Up ◽

Engineering Management ◽

Significant Rise ◽

Limited Resources ◽

Multidisciplinary Teams ◽

Interdisciplinary Relationships ◽

Human Centred Design

Over that last few decades there has been a significant rise in interest for design-led entrepreneurship and innovation. This has brought about the need to expand on the principles and methods of human-centred design by incorporating knowledge from multiple disciplines, such as management, business, and entrepreneurship studies. This expansion aids designers, engineers, and marketing practitioners who strive to create innovative, meaningful and relevant services, business models and experiences. More often than not, ventures operate under very limited resources, and practitioners are often required to fulfil several roles. The concept of ‘multidisciplinary teams’ widely spread in this sphere often bears little resonance in these contexts. Designers possess valuable competencies that can have a significant impact on the venture, especially driving user and context-centred strategy and processes for the introduction, legitimization and scaling-up stages. However, engaging with these areas of practice requires skills and capacities that overlap traditional disciplinary roles. In doing so, the boundaries between design and engineering, branding and communications, cultural and behavioural insight, marketing and management strategy are blurred. As educators in design innovation, how do we explore, define and balance interdisciplinary relationships between design, engineering, management, business and entrepreneurship theories, methods, language and models of education? The purpose of the entrepreneurship in design education track is to discuss methods, models, case studies, research, insights and unexpected knowledge in benefits and limitations of design entrepreneurship education. In particular, the three papers presented in this track demonstrate different approaches to entrepreneurship and design education.

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