scholarly journals Activity in nodose ganglia neurons after treatment with CP 55,940 and cholecystokinin

2018 ◽  
Vol 6 (23) ◽  
pp. e13927 ◽  
Author(s):  
Juliane R. Johnston ◽  
Kimberly G. Freeman ◽  
Gaylen L. Edwards
Keyword(s):  
Nodose Ganglia ◽  
Cp 55,940

scholarly journals Activity in neurons from the nodose ganglia after treatment with CP 55,940 and cholecystokinin

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Juliane M Rose ◽  
Kimberly G Freeman ◽  
Gaylen L Edwards
Keyword(s):  
Nodose Ganglia ◽  
Cp 55,940

scholarly journals The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide

2013 ◽  
Vol 8 (4) ◽  
pp. 447-454 ◽  
Author(s):  
Hong Kan ◽  
Zhongxin Wu ◽  
Yen-Chang Lin ◽  
Teh-Hsun Chen ◽  
Jared L Cumpston ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Cardiovascular Function ◽  
Pulmonary Exposure ◽  
Nodose Ganglia

Electrophysiological and autoradiographical evidence for cholecystokinin A receptors on rat isolated nodose ganglia

1994 ◽  
Vol 46 (1-2) ◽  
pp. 65-73 ◽  
Author(s):  
Robert E. Widdop ◽  
Elena Krstew ◽  
Linda D. Mercer ◽  
Mats Carlsberg ◽  
Philip M. Beart ◽  
...  
Keyword(s):  
Nodose Ganglia

Heterotopic transplantation of presumptive placodal ectoderm changes the fate of sensory neuron precursors

Development ◽  
1993 ◽  
Vol 119 (1) ◽  
pp. 263-276 ◽  
Author(s):  
K.S. Vogel ◽  
A.M. Davies
Keyword(s):  
Growth Rate ◽  
Sensory Neurons ◽  
Chicken Embryo ◽  
Neurite Growth ◽  
Heterotopic Transplantation ◽  
Growth And Survival ◽  
Avian Embryos ◽  
Nodose Ganglia ◽  
Innervation Patterns

The placode-derived cranial sensory neurons of the vestibular and nodose ganglia in avian embryos exhibit differences in neurite growth rate and the duration of neurotrophin-independent survival in vitro that arise prior to gangliogenesis and target contact (Davies, A. M. (1989) Nature 337, 553–555; Vogel, K. S. and Davies, A. M. (1991) Neuron 7, 819–830). To ascertain the state of commitment of presumptive placodal ectoderm to differentiate into neurons of the vestibular or nodose type, we performed heterotopic transplantation of labelled presumptive placodal ectoderm at E1.5 in the chicken embryo. We then assayed transplant-derived neurons for hindbrain innervation patterns, neurite growth and survival at E3.5. We show that presumptive placodal ectoderm is not determined to give rise to neurons of the vestibular or nodose phenotype at E1.5. Explantation of presumptive placodal ectoderm at E1.5 showed that this ectoderm is also not specified to differentiate into neurons at this stage. In addition, we demonstrate that non-neurogenic ectoderm from the trunk can give rise to nodose-type neurons when transplanted heterotopically to the nodose region.

scholarly journals Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains

2018 ◽  
Vol 11 ◽  
Author(s):  
Emma Leishman ◽  
Michelle N. Murphy ◽  
Michelle I. Murphy ◽  
Ken Mackie ◽  
Heather B. Bradshaw
Keyword(s):  
Adult Female ◽  
Female Mouse ◽  
Synthetic Cannabinoid ◽  
Cp 55,940

scholarly journals Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract

2011 ◽  
Vol 105 (6) ◽  
pp. 2772-2780 ◽  
Author(s):  
Angelina Ramirez-Navarro ◽  
Patricia A. Glazebrook ◽  
Michelle Kane-Sutton ◽  
Caroline Padro ◽  
David D. Kline ◽  
...  
Keyword(s):  
Action Potential ◽  
Transmitter Release ◽  
Brain Slices ◽  
Presynaptic Terminal ◽  
Solitary Tract ◽  
Sensory Afferents ◽  
Peripheral Neurons ◽  
C Fibers ◽  
Nodose Ganglia ◽  
Nucleus Of Solitary Tract

The voltage-gated K+ channel Kv1.3 has been reported to regulate transmitter release in select central and peripheral neurons. In this study, we evaluated its role at the synapse between visceral sensory afferents and secondary neurons in the nucleus of the solitary tract (NTS). We identified mRNA and protein for Kv1.3 in rat nodose ganglia using RT-PCR and Western blot analysis. In immunohistochemical experiments, anti-Kv1.3 immunoreactivity was very strong in internal organelles in the soma of nodose neurons with a weaker distribution near the plasma membrane. Anti-Kv1.3 was also identified in the axonal branches that project centrally, including their presynaptic terminals in the medial and commissural NTS. In current-clamp experiments, margatoxin (MgTx), a high-affinity blocker of Kv1.3, produced an increase in action potential duration in C-type but not A- or Ah-type neurons. To evaluate the role of Kv1.3 at the presynaptic terminal, we examined the effect of MgTx on tract evoked monosynaptic excitatory postsynaptic currents (EPSCs) in brain slices of the NTS. MgTx increased the amplitude of evoked EPSCs in a subset of neurons, with the major increase occurring during the first stimuli in a 20-Hz train. These data, together with the results from somal recordings, support the hypothesis that Kv1.3 regulates the duration of the action potential in the presynaptic terminal of C fibers, limiting transmitter release to the postsynaptic cell.

Sign in / Sign up

Export Citation Format

Share Document