scholarly journals Optic disc edema and chorioretinal folds develop during strict 6° head‐down tilt bed rest with or without artificial gravity

2021 ◽  
Vol 9 (15) ◽  
Author(s):  
Steven S. Laurie ◽  
Scott H. Greenwald ◽  
Karina Marshall‐Goebel ◽  
Laura P. Pardon ◽  
Akash Gupta ◽  
...  
Keyword(s):  
Optic Disc ◽  
Bed Rest ◽  
Artificial Gravity ◽  
Optic Disc Edema ◽  
Disc Edema ◽  
Chorioretinal Folds

Optic Disc Edema after 30 Days of Strict Head-down Tilt Bed Rest

Ophthalmology ◽  
2019 ◽  
Vol 126 (3) ◽  
pp. 467-468 ◽  
Author(s):  
Steven S. Laurie ◽  
Brandon R. Macias ◽  
Jocelyn T. Dunn ◽  
Millennia Young ◽  
Claudia Stern ◽  
...  
Keyword(s):  
Optic Disc ◽  
Bed Rest ◽  
Optic Disc Edema ◽  
Disc Edema

scholarly journals Optic Disc Edema and Choroidal Engorgement in Astronauts During Spaceflight and Individuals Exposed to Bed Rest

2020 ◽  
Vol 138 (2) ◽  
pp. 165 ◽  
Author(s):  
Steven S. Laurie ◽  
Stuart M. C. Lee ◽  
Brandon R. Macias ◽  
Nimesh Patel ◽  
Claudia Stern ◽  
...  
Keyword(s):  
Optic Disc ◽  
Bed Rest ◽  
Optic Disc Edema ◽  
Disc Edema

scholarly journals MTRR 66 and SHMT1 1420 Variants Are Associated with Optic Disc Edema During 30-d Strict Head-down Tilt Bed Rest and CO2 Exposure (P24-036-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Scott Smith ◽  
Steven Laurie ◽  
Millennia Young ◽  
Sara Zwart
Keyword(s):  
Optic Disc ◽  
Structural Changes ◽  
Space Station ◽  
Bed Rest ◽  
Nucleotide Polymorphisms ◽  
Optic Disc Edema ◽  
Disc Edema ◽  
Vitamin Status ◽  
German Aerospace ◽  
B Vitamin

Abstract Objectives Some astronauts returning from missions to the International Space Station (ISS) have developed ophthalmic structural changes, including optic disc edema. Incidence of optic disc edema among astronauts has been linked to one-carbon pathway genetic variants and B-vitamin status. A recent 30-d 6-degree head-down tilt bed rest study in which all subjects were exposed to 0.5% CO2 documented the occurrence of optic disc edema in 5 of 11 subjects. The objective of this study was to determine the effect of one-carbon pathway genetics and B-vitamin status on the incidence of optic disc edema in the bed rest subjects. Methods The study was conducted at the : envihab facility at the German Aerospace Center in Cologne, Germany. Subjects (6 M/5F) were healthy volunteers, 33 ± 8 y (mean ± SD), having a mean BMI of 23.4 ± 2.2 kg/m2. After a 14-d ambulatory phase in a standard environment (i.e., not hypercapnic), a blood sample was collected to assess vitamin status and single nucleotide polymorphisms (SNPs) associated with one carbon metabolism. We focused on two SNPs (rs1801394, MTRR 66 and rs1979227, SHMT1 1420) based on our earlier findings in astronauts (Zwart et al., FASEB J, 30:141–8, 2016). The 30-d bed rest began after collection of this sample. Optical coherence tomography images were collected before, during (days 15 and 30), and after (6 and 13 days after reambulation) bed rest, and the change in total retinal thickness (TRT) at various distances from Bruch's membrane opening (BMO) was evaluated against the number of MTRR A66G G alleles and SHMT1 C1420T C alleles. Results The change in TRT at various distances from the BMO in bed rest subjects exposed to mild hypercapnia and headward fluid shifts was strongly associated with the number of MTRR 66 G and SHMT1 1420 C alleles. Conclusions This finding may increase understanding of mechanisms involved in optic disc edema in astronauts and patients on Earth, and hence lead to development of targeted countermeasures. Funding Sources This work was funded by the NASA Human Health Countermeasures Element of the NASA Human Research Program.

scholarly journals Association of Genetics and B Vitamin Status With the Magnitude of Optic Disc Edema During 30-Day Strict Head-Down Tilt Bed Rest

2019 ◽  
Vol 137 (10) ◽  
pp. 1195 ◽  
Author(s):  
Sara R. Zwart ◽  
Steven S. Laurie ◽  
John J. Chen ◽  
Brandon R. Macias ◽  
Stuart M. C. Lee ◽  
...  
Keyword(s):  
Optic Disc ◽  
Bed Rest ◽  
Optic Disc Edema ◽  
Disc Edema ◽  
Vitamin Status ◽  
B Vitamin

scholarly journals Ophthalmic Changes in a Spaceflight Analog Are Associated with Brain Functional Reorganization

2020 ◽  
Author(s):  
Heather R. McGregor ◽  
Jessica K. Lee ◽  
Edwin R. Mulder ◽  
Yiri E. De Dios ◽  
Nichole E. Beltran ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Optic Disc ◽  
Resting State ◽  
Large Scale ◽  
Space Station ◽  
Bed Rest ◽  
Ambient Air ◽  
Resting State Functional Connectivity ◽  
Optic Disc Edema ◽  
Disc Edema

ABSTRACTImportanceFollowing long-duration missions onboard the International Space Station, some astronauts develop ophthalmic abnormalities collectively referred to as Spaceflight Associated Neuro-ocular Syndrome (SANS). Optic disc edema is a common sign of SANS. SANS presents significant potential risk to astronaut health and performance; however, the origin and effects of SANS are not understood as signs of SANS have not manifested in previous spaceflight analog studies.ObjectiveTo investigate whether development of optic disc edema during a spaceflight analog impacts resting-state functional connectivity.Design, Setting and ParticipantsEleven healthy volunteers participated in this 58-day longitudinal study conducted at the :envihab facility at the German Aerospace Center.Interventions or ExposuresBaseline data were collected during a 14-day ambulatory phase in standard ambient air. All participants then underwent a spaceflight analog intervention: 30 days of strict head-down tilt bed rest in elevated ambient carbon dioxide (HDBR+CO2). The elevated CO2 level (0.5%) was matched to the hypercapnic environment of the International Space Station. The intervention was followed by a 14-day ambulatory recovery phase in standard ambient air. During the HDBR+CO2 spaceflight analog, 5 participants developed optic disc edema (SANS subgroup) and 6 did not (NoSANS group).Main Outcomes and MeasuresUsing functional magnetic resonance imaging (fMRI), we acquired resting-state data at 6 time points throughout the study: before (2), during (2), and after (2) the HDBR+CO2 intervention. We assessed the time course of resting-state functional connectivity changes from before, during, to after the HDBR+CO2, and contrasted longitudinal changes between the SANS and NoSANS subgroups. We also assessed if the SANS and NoSANS subgroups exhibited differential patterns of resting-state functional connectivity prior to the HDBR+CO2 intervention.ResultsThe SANS and NoSANS subgroups exhibited differential patterns of resting-state connectivity changes during the HDBR+CO2 spaceflight analog within visual and vestibular-related brain networks. We further found that the SANS and NoSANS subgroups exhibited differential resting-state brain activity prior to the spaceflight analog within a visual cortical network and within a large-scale network of brain areas involved in multisensory integration.Conclusions and RelevanceSubgroup differences in resting-state functional connectivity changes may reflect differential patterns of visual and vestibular reweighting as optic disc edema develops during the HDBR+CO2 spaceflight analog. This finding suggests that SANS impacts not only neuro-ocular structures, but also brain function. Future prospective investigations incorporating sensory assessments are required to determine the functional significance of the observed connectivity differences.KEY POINTSQuestionDoes optic disc edema development during head-down tilt bed rest with elevated carbon dioxide impact brain resting-state functional connectivity?FindingsA subset of participants developed optic disc edema during the head-down tilt bed rest intervention with elevated ambient CO2. Participants who developed optic disc edema exhibited a distinct pattern of resting-state functional connectivity changes within visual and vestibular-related networks during the spaceflight analog compared to participants who did not. Participants who developed optic disc edema exhibited different resting-state brain activity prior to the spaceflight analog within a visual cortical network and within a large-scale network of brain areas involved in multisensory integration.MeaningDevelopment of optic disc edema was associated with distinct patterns of brain resting-state functional connectivity during and prior to the spaceflight analog.

scholarly journals Asymmetric optic disc edema in a young patient with POEMS: A rare presentation of a rare disease

2021 ◽  
Vol 22 ◽  
pp. 101064
Author(s):  
Hana Mahallati ◽  
James Kirkland Roberts ◽  
Amer Assal ◽  
Divaya Bhutani ◽  
David C. Park ◽  
...  
Keyword(s):  
Rare Disease ◽  
Young Patient ◽  
Optic Disc ◽  
Optic Disc Edema ◽  
Rare Presentation ◽  
Disc Edema

scholarly journals A Fronto-ethmoidal Sinus Mucocele presenting with optic disc edema

2021 ◽  
Vol 16 (11) ◽  
pp. 3410-3413
Author(s):  
Yu Xia
Keyword(s):  
Optic Disc ◽  
Optic Disc Edema ◽  
Disc Edema ◽  
Ethmoidal Sinus

Perthes syndrome associated with bilateral optic disc edema

2006 ◽  
Vol 41 (6) ◽  
pp. 780-782 ◽  
Author(s):  
Hidir Esme ◽  
Okan Solak ◽  
Yusuf Yurumez ◽  
Samet Ermis ◽  
Mehmet Yaman ◽  
...  
Keyword(s):  
Optic Disc ◽  
Optic Disc Edema ◽  
Disc Edema

scholarly journals Optic Disc Edema From Remote Uveal Melanoma

2013 ◽  
Vol 131 (1) ◽  
pp. 115 ◽  
Author(s):  
Sireesha A. Clark ◽  
Martin Lubow ◽  
Abhik Ray-Chaudhury ◽  
Frederick H. Davidorf ◽  
Mohamed H. Abdel-Rahman ◽  
...  
Keyword(s):  
Optic Disc ◽  
Uveal Melanoma ◽  
Optic Disc Edema ◽  
Disc Edema

Bilateral Hemorrhagic Optic Disc Edema in a Middle-aged Man

2022 ◽  
Author(s):  
Crystal Y. Lee ◽  
Matthew R. Starr ◽  
James P. Dunn
Keyword(s):  
Optic Disc ◽  
Middle Aged ◽  
Optic Disc Edema ◽  
Disc Edema
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