scholarly journals TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

2005 ◽  
Vol 52 (2) ◽  
pp. 213-217 ◽  
Author(s):  
Aysin OGE ◽  
Firat BAYRAKTAR ◽  
Fusun SAYGILI ◽  
Engin GUNEY ◽  
Serap DEMIR
Keyword(s):  
Thyroid Hormones ◽  
Serum Leptin ◽  
Hyperthyroid Patients

Lack of effects of circulating thyroid hormone levels on serum leptin concentrations

1997 ◽  
pp. 659-663 ◽  
Author(s):  
S Corbetta ◽  
P Englaro ◽  
S Giambona ◽  
L Persani ◽  
WF Blum ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Standard Deviation Score ◽  
Protein Product ◽  
Primary Hypothyroidism ◽  
Central Hypothyroidism ◽  
Serum Leptin ◽  
Thyroxine Therapy ◽  
Significant Difference ◽  
Before And After ◽  
Thyroxine Replacement Therapy

Leptin is the protein product of the ob gene, secreted by adipocytes. It has been suggested that it may play an important role in regulating appetite and energy expenditure. The aim of this study was to evaluate a possible interaction of thyroid hormones with the leptin system. We studied 114 adult patients (65 females and 49 males): 36 were affected with primary hypothyroidism (PH), 38 with central hypothyroidism (CH) and 40 with thyrotoxicosis (TT). Patients with CH were studied both before and after 6 months of L-thyroxine replacement therapy. Body mass index (BMI; kg/m2), thyroid function and fasting serum leptin were assessed in all patients. Since BMI has been proved to be the major influencing variable of circulating leptin levels, data were expressed as standard deviation score (SDS) calculated from 393 male and 561 female controls matched for age and BMI. No difference in SDS was recorded between males and females whatever the levels of circulating thyroid hormones. In males, no significant difference was recorded among the SDSs of PH (-0.36 +/- 1.2), TT (-0.35 +/- 1.2) and CH (0.01 +/- 1.4) patients. Females with PH had an SDSs significantly lower than TT females (-0.77 +/- 1.0 vs -0.06 +/- 1.2; P < 0.02), while no significant differences between CH (-0.34 +/- 0.7) and TT females or between CH and PH females were observed. SDS in CH patients after 6 months of L-thyroxine therapy significantly varied only in females (0.25 +/- 1.4). In conclusion, circulating thyroid hormones do not appear to play any relevant role in leptin synthesis and secretion. However, as females with either overt hypo- or hyper-thyroidism or central hypothyroidism after L-thyroxine therapy show differences in their SDSs, a subtle interaction between sex steroids and thyroid status in modulating leptin secretion, at least in women, may occur.

Red-cell 2,3-diphosphoglycerate in patients with hyperthyroidism

1980 ◽  
Vol 93 (4) ◽  
pp. 424-429 ◽  
Author(s):  
J. L. Alvarez-Sala ◽  
M. A. Urbán ◽  
J. J. Sicilia ◽  
A. J. Diaz Fdez ◽  
F. Fdez Mendieta ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Control Group ◽  
Red Cell ◽  
Oxygen Dissociation Curve ◽  
Dissociation Curve ◽  
Oxygen Dissociation ◽  
The Right ◽  
Serum Thyroid Hormones ◽  
Hyperthyroid Patients ◽  
2,3 Dpg

Abstract. In 21 hyperthyroid female patients studied on 29 occasions, high levels of red-cell 2,3-diphosphoglycerate (2,3-DPG) have been found (5.75 ± 0.7 mm) which, compared to a euthyroid control group (4.88 ± 0.4 mm), could not be accounted for by differences in haematocrit, haemoglobin or phosphataemia. A significant correlation was found (P < 0.05) between serum thyroid hormones and the 2,3-DPG concentration in the hyperthyroid patients. Eight of these patients were reexamined after treatment and normalization of thyroid function, showed a regression to normal 2,3-DPG values (4.81 ± 0.6 mm) which could not be attributed to variations in haematocrit, haemoglobin or phosphataemia either. We therefore deduce that the shift to the right in the haemoglobin oxygen dissociation curve observed in patients of this type may be due to an increase in the red-cell 2,3-DPG content.

scholarly journals Effects of Hypo- and Hyperthyroidism on Noradrenergic Activity and Glycerol Concentrations in Human Subcutaneous Abdominal Adipose Tissue Assessed with Microdialysis

2003 ◽  
Vol 88 (12) ◽  
pp. 5605-5608 ◽  
Author(s):  
Martin Haluzik ◽  
Jara Nedvidkova ◽  
Vladimir Bartak ◽  
Ivana Dostalova ◽  
Petr Vlcek ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormones ◽  
Relative Magnitude ◽  
In Vivo Microdialysis ◽  
Abdominal Adipose Tissue ◽  
Subcutaneous Abdominal Adipose Tissue ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients ◽  
Tissue Norepinephrine

Abstract Thyroid hormones play a major role in lipid metabolism. However, whether they directly affect lipolysis locally in the adipose tissue remains unknown. Therefore, we measured abdominal sc adipose tissue norepinephrine (NE), basal, and isoprenaline-stimulated lipolysis in 12 hypothyroid patients (HYPO), six hyperthyroid patients (HYPER), and 12 healthy controls by in vivo microdialysis. Adipose tissue NE was decreased in HYPO and increased in HYPER compared with controls (90.4 ± 2.9 and 458.0 ± 69.1 vs. 294.9 ± 19.5 pmol/liter, P &lt; 0.01). Similarly, basal lipolysis, assessed by glycerol assay, was lower in HYPO and higher in HYPER than in controls (88.2 ± 9.9 and 566.0 ± 42.0 vs. 214.3 ± 5.1 μmol/liter P &lt; 0.01). The relative magnitude of isoprenaline-induced glycerol increase was smaller in HYPO (39 ± 19.4%, P &lt; 0.05 vs. basal) and higher in HYPER (277 ± 30.4%, P &lt; 0.01) than in controls (117 ± 5.6%, P &lt; 0.01). The corresponding changes in NE after isoprenaline stimulation were as follows: 120 ± 9.2% (P &lt; 0.05), 503 ± 113% (P &lt; 0.01), and 267 ± 17.2 (P &lt; 0.01). In summary, by affecting local NE levels and adrenergic postreceptor signaling, thyroid hormones may influence the lipolysis rate in the abdominal sc adipose tissue.

Role of thyroid hormones on serum leptin levels

1998 ◽  
Vol 139 (4) ◽  
pp. 428-430 ◽  
Author(s):  
G Sesmilo ◽  
R Casamitjana ◽  
I Halperin ◽  
R Gomis ◽  
E Vilardell
Keyword(s):  
Thyroid Hormones ◽  
Serum Leptin

Short Term Under- and Over-Feeding Has No Effect on Serum Leptin or Thyroid Hormones

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 668-669
Author(s):  
David W. DeGroot ◽  
Matthew R. Ely ◽  
J Philip Karl ◽  
Andrew J. Young
Keyword(s):  
Thyroid Hormones ◽  
Short Term ◽  
Serum Leptin

Thyroid Hormones Influence Serum Leptin Levels in Patients with Graves' Disease During Suppression of β-Adrenergic Receptors

Thyroid ◽  
2000 ◽  
Vol 10 (8) ◽  
pp. 641-646 ◽  
Author(s):  
Nobuko Sera ◽  
Naokata Yokoyama ◽  
Yasuyo Abe ◽  
Akane Ide ◽  
Misa Imaizumi ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Adrenergic Receptors ◽  
Graves Disease ◽  
Serum Leptin ◽  
Β Adrenergic Receptors

THYROID FUNCTION AND PLASMA CYCLIC AMP RESPONSE TO INTRAVENOUS GLUCAGON

1977 ◽  
Vol 85 (4) ◽  
pp. 760-768 ◽  
Author(s):  
S. Nistrup Madsen
Keyword(s):  
Cyclic Amp ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Healthy Subjects ◽  
Blood Levels ◽  
Sensitive Test ◽  
Normal Response ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

ABSTRACT The glucagon stimulated increase in plasma cyclic AMP has been studied in 17 healthy subjects, in 13 hyperthyroid and in 14 hypothyroid patients. Six hyperthyroid and 2 hypothyroid patients were re-investigated after at least 15 months of treatment. The results show: 1) The glucagon stimulated cyclic AMP response is significantly increased in hyperthyroid patients considered as a group, and is reduced in patients with hypothyroidism. 2) Three hyperthyroid and 4 hypothyroid patients showed a normal response to iv glucagon, indicating that the plasma cyclic AMP response to iv glucagon is not a sensitive test for the evaluation of peripheral thyroid states. This suggests that the effects of thyroid hormones in the liver does not necessarily follow the effects in other tissues. 3) Re-investigation of treated patients showed that the cyclic AMP response can be normalized by treatment, both in hyperthyroidism and in hypothyroidism. However, in patients treated for hyperthyroidism a hyper-response to glucagon can continue after blood levels of thyroid hormones are reduced to normal. This suggests an inertia in the loss of the hyper-response to glucagon, once a hyperfunction has been induced. A similar inertia in the loss of glucagon sensitivity in hypothyroidism could explain the large number of normal tests in hypothyroid patients.

Pharmacokinetics of Bisoprolol and Influence on Serum Thyroid Hormones in Hyperthyroid Patients

1985 ◽  
Vol 8 ◽  
pp. S100-S105
Author(s):  
P. Pfannenstiel ◽  
E. Rummeny ◽  
Th. Baew-Christow ◽  
B. Bux ◽  
M. Cordes ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Serum Thyroid Hormones ◽  
Hyperthyroid Patients

ALTERATIONS OF THYROXINE-BINDING PROTEIN IN CLINICALLY HYPO- AND HYPERTHYROID PATIENTS WITH NORMAL PBI LEVEL

1964 ◽  
Vol 45 (1) ◽  
pp. 99-113 ◽  
Author(s):  
Th. Lemarchand-Béraud ◽  
M.-R. Assayah ◽  
A. Vannotti
Keyword(s):  
Thyroid Hormones ◽  
Binding Capacity ◽  
Binding Protein ◽  
Infectious Hepatitis ◽  
Low Level ◽  
Elevated Protein ◽  
Hyperthyroid Patients ◽  
In Vitro Uptake

ABSTRACT Six patients, clinically hypothyroid in spite of a normal or elevated protein-bound iodine (PBI) level, and six hyperthyroid patients with a low level of PBI are described. In these patients, a probable modification of the transport of the thyroid hormones is revealed by means of in vitro uptake of T3 by erythrocytes (Hamolsky's test) and by the determination of the binding capacity of the thyroxine-binding protein (TBP or TBG). In the first group, the labelled triiodothyronine uptake by the erythrocytes is low and the TBP-binding capacity is higher than normal. In the second group, the elevated percentage of free hormones and the low TBP-binding capacity may partly explain the hyperthyroidism despite the low PBI level. PBI concentration in the thyrotoxic range with high TBP binding capacity, is also demonstrated in infectious hepatitis. The meaning of these results is discussed.

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