Lack of effects of circulating thyroid hormone levels on serum leptin concentrations

1997 ◽  
pp. 659-663 ◽  
Author(s):  
S Corbetta ◽  
P Englaro ◽  
S Giambona ◽  
L Persani ◽  
WF Blum ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Standard Deviation Score ◽  
Protein Product ◽  
Primary Hypothyroidism ◽  
Central Hypothyroidism ◽  
Serum Leptin ◽  
Thyroxine Therapy ◽  
Significant Difference ◽  
Before And After ◽  
Thyroxine Replacement Therapy

Leptin is the protein product of the ob gene, secreted by adipocytes. It has been suggested that it may play an important role in regulating appetite and energy expenditure. The aim of this study was to evaluate a possible interaction of thyroid hormones with the leptin system. We studied 114 adult patients (65 females and 49 males): 36 were affected with primary hypothyroidism (PH), 38 with central hypothyroidism (CH) and 40 with thyrotoxicosis (TT). Patients with CH were studied both before and after 6 months of L-thyroxine replacement therapy. Body mass index (BMI; kg/m2), thyroid function and fasting serum leptin were assessed in all patients. Since BMI has been proved to be the major influencing variable of circulating leptin levels, data were expressed as standard deviation score (SDS) calculated from 393 male and 561 female controls matched for age and BMI. No difference in SDS was recorded between males and females whatever the levels of circulating thyroid hormones. In males, no significant difference was recorded among the SDSs of PH (-0.36 +/- 1.2), TT (-0.35 +/- 1.2) and CH (0.01 +/- 1.4) patients. Females with PH had an SDSs significantly lower than TT females (-0.77 +/- 1.0 vs -0.06 +/- 1.2; P < 0.02), while no significant differences between CH (-0.34 +/- 0.7) and TT females or between CH and PH females were observed. SDS in CH patients after 6 months of L-thyroxine therapy significantly varied only in females (0.25 +/- 1.4). In conclusion, circulating thyroid hormones do not appear to play any relevant role in leptin synthesis and secretion. However, as females with either overt hypo- or hyper-thyroidism or central hypothyroidism after L-thyroxine therapy show differences in their SDSs, a subtle interaction between sex steroids and thyroid status in modulating leptin secretion, at least in women, may occur.

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism

2021 ◽  
Vol 16 ◽  
Author(s):  
Reihaneh Rezaee ◽  
Masoud Mohebbi ◽  
Mozhgan Afkhamizadeh ◽  
Mohammad Ali Yaghoubi ◽  
Mona Najaf Najafi ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Intervention Group ◽  
Serum Levels ◽  
Overt Hypothyroidism ◽  
Serum Osteocalcin ◽  
Significant Difference ◽  
Before And After ◽  
Metabolic Conditions ◽  
And Control

Background and Objective: Subclinical hypothyroidism can potentially develop to overt hypothyroidism. Thyroid hormones have substantial roles in metabolism and glucose homeostasis and thus are closely related to determinant factors of metabolic syndromes, such as obesity and insulin resistance. Osteocalcin is considered a predictor of metabolic conditions in thyroid diseases. This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism. Methods: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric data, were measured at baseline and at the end of the study. SPSS was used to analyze the data and P<0.05 was considered significant. Results: Mean age in the intervention and control groups was 35.07 ± 9.94 and 31.30 ± 4.30, respectively (P=0.20). There was no significant difference between osteocalcin levels before and after the intervention in either of the groups (P=0.54). TSH level was significantly decreased in the levothyroxine group after the intervention (P<0.01). T4 level was significantly increased in the intervention group (P=0.02). Conclusion: Levothyroxine had no significant effect on increasing the levels of serum osteocalcin in patients with subclinical hypothyroidism. We have registered the trial in the Iranian registry of clinical trials (IRCT) with the registration code IRCT20171129037677N1.

THE EFFECT OF PERCUTANEOUS CORONARY INTERVENTION (PCI) WITH DES ON ANTITHROMBIN-III (AT-III) AND THROMBIN ANTITHROMBIN COMPLEX (TAT) IN CORONARY HEART DISEASE PATIENTS AT HAJI ADAM MALIK GENERAL HOSPITAL

2020 ◽  
Vol 8 (1) ◽  
pp. 8-11
Keyword(s):  
Adipose Tissue ◽  
Energy Homeostasis ◽  
Coronary Intervention ◽  
Open Label ◽  
Tissue Mass ◽  
Serum Leptin ◽  
Abnormal Growth ◽  
Significant Difference ◽  
Before And After ◽  
Ethics Commission

Cancer is a disease caused by the abnormal growth of tissue cells that turn into cancer cells. Cancer can cause severe adverse effects for nutritional status. One of the nutritional problems that need attention in cancer patients is cachexia. The pathophysiology of cancer cahexia is multifactorial and not fully understood. Until now, the inflammation is a common concept raised by several studies on cancer cachexia. Leptin is a hormone produced by adipose tissue and is a member of adipocytokines that play a role in adipose tissue signaling hormones. Leptin plays an important role in signaling that regulates energy homeostasis is both central and peripheral, reduce appetite, adipose tissue mass and body weight. Cork fish or Snakehead (Family Channidae) are known to contain higher protein than other fish species. Cork fish is a potential source of albumin. This study was conducted with the aim to determine the effect of cork fish extract on serum leptin levels in cancer cahexia patients. This study is an open label clinical trial with one group pretest-posttest design. The study was conducted in July - December 2019 at the Haji Adam Malik Hospital in Medan with the approval of the USU FK Research Ethics Commission. Data were analyzed using SPPS program where p <0.05 was considered significant. This study showed that there was a significant difference in the serum leptin levels of the subjects before and after receiving Ophiocephalus striatus extract for two weeks.

Causes and laboratory investigation of hypothyroidism

2011 ◽  
pp. 530-537 ◽  
Author(s):  
Ferruccio Santini ◽  
Aldo Pinchera
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Thyroid Hormone Receptor ◽  
Hormone Secretion ◽  
Thyroid Tissue ◽  
Clinical Manifestations ◽  
Primary Hypothyroidism ◽  
Central Hypothyroidism ◽  
Resistance To Thyroid Hormones

Hypothyroidism is the clinical state that develops as a result of the lack of action of thyroid hormones on target tissues (1). Hypothyroidism is usually due to impaired hormone secretion by the thyroid, resulting in reduced concentrations of serum thyroxine (T4) and triiodothyronine (T3). The term primary hypothyroidism is applied to define the thyroid failure deriving from inherited or acquired causes that act directly on the thyroid gland by reducing the amount of functioning thyroid tissue or by inhibiting thyroid hormone production. The term central hypothyroidism is used when pituitary or hypothalamic abnormalities result in an insufficient stimulation of an otherwise normal thyroid gland. Both primary and central hypothyroidism may be transient, depending on the nature and the extent of the causal agent. Hypothyroidism following a minor loss of thyroid tissue can be recovered by compensatory hyperplasia of the residual gland. Similarly, hypothyroidism subsides when an exogenous inhibitor of thyroid function is removed. Peripheral hypothyroidism may also arise as a consequence of tissue resistance to thyroid hormones due to a mutation in the thyroid hormone receptor. Resistance to thyroid hormones is a heterogeneous clinical entity with most patients appearing to be clinically euthyroid while some of them have symptoms of thyrotoxicosis and others display selected signs of hypothyroidism. The common feature is represented by pituitary resistance to thyroid hormones, leading to increased secretion of thyrotropin that in turn stimulates thyroid growth and function. The variability in clinical manifestations depends on the severity of the hormonal resistance, the relative degree of tissue hyposensitivity, and the coexistence of associated genetic defects (see Chapter 3.4.8).

scholarly journals Interleukin 1α Increases Serum Leptin Concentrations in Humans

1997 ◽  
Vol 82 (9) ◽  
pp. 3084-3086 ◽  
Author(s):  
John E. Janik ◽  
Brendan D. Curti ◽  
Robert V. Considine ◽  
Helen C. Rager ◽  
Geraldine C. Powers ◽  
...  
Keyword(s):  
Body Weight ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Protein Product ◽  
Serum Leptin ◽  
Patients With Cancer ◽  
Before And After ◽  
Interleukin 1Α ◽  
Dose Levels ◽  
Necrosis Factor

Abstract Leptin, the protein product of the ob gene, regulates appetite and body weight in animals. Endotoxin and cytokines, induced by endotoxin, interleukin (IL) 1 and tumor necrosis factor, increase expression of leptin in mice and hamsters. We measured serum leptin concentrations in patients with cancer before and after administration of recombinant human IL-1α. Fourteen patients received IL-1α at one of three dose levels (0.03, 0.1, or 0.3 μg/kg·day) for 5 days. Serum leptin concentrations increased in all but two patients within 24 h after the first dose. The increase in leptin was correlated directly with IL-1α dose (P = 0.0030). Despite continued administration of IL-1α, serum leptin concentrations returned to pretreatment levels by day 5 of therapy. An increase in serum leptin concentrations may be one mechanism by which anorexia is induced by IL-1α. However, tachyphylaxis of the leptin response suggests that other mechanisms also are involved.

scholarly journals Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Reza M. Robati ◽  
Parviz Toossi ◽  
Mohammad Rahmati-Roodsari ◽  
Sara Khalilazar ◽  
Ehsan Abolhasani ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Serum Cortisol ◽  
Severity Index ◽  
Thyroid Stimulating Hormone ◽  
Serum Prolactin ◽  
Significant Difference ◽  
Before And After ◽  
Pasi Score ◽  
Cortisol Levels ◽  
Normal Controls

Background. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although the previous studies reported different results.Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a difference in prolactin, thyroid stimulating hormone (TSH), thyroid hormones (T3and T4), and cortisol levels between patients with psoriasis and normal controls.Methods. First, the levels of hormones were measured in 30 patients with psoriasis and 30 matched controls. The severity was assessed by psoriasis area and severity index (PASI). Then, patients were treated, and PASI was assessed every week until achieving PASI-75 response. At this time, the hormones were measured again and compared to the baseline.Results. No statistical significant difference was observed in the mean PRL, T3, T4, TSH, and cortisol levels between cases and controls. Comparing to the baseline, a significant decrease in PRL levels and a significant increase in T3and serum cortisol levels were observed after treatment (P<0.05), while the changes in other hormones were not significant.Conclusion. After treatment, PRL significantly decreased, and T3and cortisol levels significantly increased. No correlation between hormone levels and improvement of PASI score existed.

scholarly journals Severe Acquired Primary Hypothyroidism in Children and its Influence on Growth: A Retrospective Analysis of 43 Cases

2021 ◽  
Author(s):  
Marianne Becker ◽  
Oliver Blankenstein ◽  
Erwin Lankes ◽  
Dirk Schnabel ◽  
Heiko Krude
Keyword(s):  
Autoimmune Thyroiditis ◽  
Standard Deviation Score ◽  
Rare Condition ◽  
Primary Hypothyroidism ◽  
University Hospital ◽  
Drug Induced ◽  
Thyroxine Therapy ◽  
Presenting Symptoms ◽  
Number Of Patients ◽  
Catch Up

Abstract Introduction Severe acquired hypothyroidism in childhood is a rare condition, mostly caused by autoimmune thyroiditis. Scarce and inconsistent data based on small patient numbers exist concerning its impact on growth in height. Methods Patient files at a single centre university hospital over 8 years were retrospectively reviewed. We identified 43 patients (mean age 10.6 years, 3.3–15.25, 59% prepubertal, 88% females) in a cohort of children older than 3 years with an initial TSH>30 mIU/l and reduced T4 or fT4; congenital and drug-induced hypothyroidism were excluded. Results All patients had signs of autoimmune thyroiditis (93% positive autoantibodies, 95% typical ultrasonography, 63% goiter). Median TSH was 100 mIU/l [0.3–4 mIU/l]), median fT4 3.55 pg/ml [8–19 pg/ml], median T4 2.85 µg/dl [5.3–11 µg/dl]. Presenting symptoms included goiter (26%), tiredness (23%), weight gain (19%), and growth retardation (19%). The diagnosis was made incidentally in 26% patients. In 75% growth was retarded (median height standard deviation score (SDS)-0.55), in 17% height SDS was<-2 at diagnosis. Midparental height SDS at diagnosis correlated significantly with T4 and fT4 (r=0.77, p=0.0012 and r=0.53, p=0.021 respectively). Catch-up growth under T4 substitution was significantly greater in prepubertal than in pubertal children (p 0.049). Conclusion This so far largest pediatric cohort with severe acquired hypothyroidism confirms a serious impact on growth which, however in most cases, showed a certain catch-up growth after adequate L-thyroxine therapy. The pubertal state seems to be important for catch-up growth. A significant number of patients were not diagnosed clinically, although affected by severe hypothyroidism.

scholarly journals THE EFFECT OF OPHIOCEPHALUS STRIATUS EXTRACT ON SERUM LEPTIN LEVEL OF CANCER CACHEXIA PATIENTS

2020 ◽  
Vol 8 (1) ◽  
pp. 1-7
Keyword(s):  
Adipose Tissue ◽  
Energy Homeostasis ◽  
Cancer Cachexia ◽  
Open Label ◽  
Tissue Mass ◽  
Serum Leptin ◽  
Abnormal Growth ◽  
Significant Difference ◽  
Before And After ◽  
Ethics Commission

Cancer is a disease caused by the abnormal growth of tissue cells that turn into cancer cells. Cancer can cause severe adverse effects for nutritional status. One of the nutritional problems that need attention in cancer patients is cachexia. The pathophysiology of cancer cahexia is multifactorial and not fully understood. Until now, the inflammation is a common concept raised by several studies on cancer cachexia. Leptin is a hormone produced by adipose tissue and is a member of adipocytokines that play a role in adipose tissue signaling hormones. Leptin plays an important role in signaling that regulates energy homeostasis is both central and peripheral, reduce appetite, adipose tissue mass and body weight. Cork fish or Snakehead (Family Channidae) are known to contain higher protein than other fish species. Cork fish is a potential source of albumin. This study was conducted with the aim to determine the effect of cork fish extract on serum leptin levels in cancer cahexia patients. This study is an open label clinical trial with one group pretest-posttest design. The study was conducted in July - December 2019 at the Haji Adam Malik Hospital in Medan with the approval of the USU FK Research Ethics Commission. Data were analyzed using SPPS program where p <0.05 was considered significant. This study showed that there was a significant difference in the serum leptin levels of the subjects before and after receiving Ophiocephalus striatus extract for two weeks.

scholarly journals STUDY OF ASSOCIATION OF RESISTIN AND LEPTIN WITH THYROID HORMONES IN HYPOTHYROID PATIENTS

2020 ◽  
Vol 8 (12) ◽  
pp. 744-750
Author(s):  
Peeyush Yadav ◽  
◽  
G.G. Kaushik ◽  
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Dysfunction ◽  
Control Group ◽  
Free T4 ◽  
Serum Leptin ◽  
Significant Difference ◽  
Coefficient Corrélation ◽  
Healthy Control ◽  
And Control ◽  
Hypothyroid Patients

Objective:The present study was aimed to evaluate the levels of resistin and leptin in hypothyroid patients and to find a possible association of thyroid hormones with resistin and leptin. Material and Methods:The present study was conducted on 100 previously diagnosed hypothyroid (PDH) patients (38 Males & 62 Females) and 100 newly diagnosed hypothyroid (NDH) patients (44 Males & 56 Females) attending the outpatient clinics or admitted in wards of J.L.N. Hospitals, Ajmer. 100 healthy control subjects of same age group of either gender were selected for the study. Blood samples were drawn from patients and controls, after overnight fast of at least 8 hours. Estimation of Serum Leptin, Resistin, free T3, free T4, and TSH was done by using Enzyme- Linked Immunosorbant Assay (ELISA) technique. Differences in the parameters among the groups were analyzed by ANOVA test followed by its Tukey HSD post hoc analysis. Correlations between variables were tested using the Pearson rho (r: Correlation coefficient) correlation test. Results:Findings of the present study shows that the levels of serum fT3 (1.79 ± 0.29 pg/mL) and serum fT4 (0.34 ± 0.11 ng/dL) were significantly lower in NDH group compared to PDH group (fT3 = 3.00 ± 0.32 pg/mL & fT4 = 0.81 ± 0.15 ng/dL) and control group (fT3 = 3.12 ± 0.31 pg/mL & fT4 = 0.85 ± 0.11ng/dL) whereas serum TSH levels were significantly higher in NDH group (40.59 ± 13.55 μIU/mL) compared to PDH group (5.34 ± 1.47 μIU/mL) and control group (3.23 ± 1.04 μIU/mL) [Table 1 Figure 1]. Serum leptin levels were significantly higher in NDH group (21.37 ± 6.44 ng/mL) compared to PDH group (16.51 ± 4.47 ng/mL) and control group (11.15 ± 5.29 ng/mL) [Table 2]. A highly significant variation (p<0.0001) in the levels of serum leptin was found between the groups. Serum resistin levels were significantly higher in NDH group (14.50 ± 2.72 ng/mL) compared to PDH group (11.33 ± 1.59 ng/mL) and control group (7.78 ± 1.19 ng/mL) [Table 2]. Highly Significant difference (p<0.0001) in resistin levels was found between the groups. Conclusion: It was suggested that thyroid dysfunction does not affect the leptin levels and also thyroid hormones were not involved in the synthesis and secretion of leptin. Further studies are required to gain more insight into the relationship between leptin and thyroid dysfunction. Resistin shows a significant correlation with thyroid hormones which indicate that serum resistin might be considered as a confirmation extra test for the early detection of atherosclerosis and atherosclerosis induced conditions in hypothyroid patients.

Advanced Oxidation Protein Product (AOPP) Levels in Second- and Third-Degree Thermal Burns

2020 ◽  
Author(s):  
Handan Mert ◽  
Suat Açikkol ◽  
İskan Çalli ◽  
Salih Çibuk ◽  
Sıddık Keskin ◽  
...  
Keyword(s):  
Total Body Surface Area ◽  
Protein Product ◽  
Thermal Burn ◽  
Thermal Burns ◽  
Hospitalization Period ◽  
Significant Difference ◽  
Before And After ◽  
Total Body ◽  
First Time ◽  
The Relationship

Abstract Burn is a systemic injury affecting the entire organism according to its etiology and severity. The aim of this study was to investigate plasma AOPP levels before and after treatment of second- and third-degree thermal burn patients and determine the changes in this parameter, and also, to find out the relationship between AOPP level and hospitalization period and total body surface area (TBSA). The study material consisted of pediatric patients with the complaint of second- and third-degree thermal burns aged between 1 and 18 years, with a burn area exceeding 10%. Blood samples were taken twice before and after treatment. AOPP level in blood plasma was measured in ELISA. It was observed that in the second-degree thermal burn group, AOPP level was 25.85 ± 2.82 ng/ml before the treatment decreased to 22.16 ± 3.62 ng/ml after treatment, whereas in the third-degree thermal burn group before the treatment AOPP was 25.96 ± 3.49 ng/ml, and after the treatment dropped to 21.70 ± 3.79 ng/ml, decreases were significantly important (P &lt; .05). There was no statistically significant difference between the two groups in terms of AOPP levels (P &gt; .05). Correlation analyses in the second- and third-degree thermal burn group did not show any correlation between AOPP levels and burn area and length of hospitalization period. As a result, AOPP level has been studied, for the first time, in burn cases. In both groups, the level of AOPP increased due to oxidative stress before treatment and decreased after treatment.

Effect of thyroid function on serum somatomedin activity

1981 ◽  
Vol 96 (4) ◽  
pp. 491-497 ◽  
Author(s):  
Josef Marek ◽  
Marie Schüllerová ◽  
Olga Schreiberová ◽  
Zdeňka Límanová
Keyword(s):  
Thyroid Hormones ◽  
Replacement Therapy ◽  
Primary Hypothyroidism ◽  
Embryonic Chick ◽  
Mean Values ◽  
Before And After ◽  
And Function ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

Abstract. To obtain more information about a possible role of somatomedins in mediating the effects of thyroid hormones on the development and function of epiphyseal cartilage, somatomedin activity, measured on the basis of 35S incorporation in embryonic chick cartilage, was studied in thyrotoxic patients before and after treatment with carbimazole or surgery and in a group of patients with primary hypothyroidism. In 29 hyperthyroid patients mean values of somatomedin were 1.29 ± 0.03 sem and differed significantly (P < 0.01) from normals (1.04 ± 0.03). In 15 carbimazole treated patients and in 5 operated patients with thyrotoxicosis somatomedin levels fell from 1.29 ± 0.04 to 1.03 ± 0.04 (P < 0.01) when the patients became euthyroid. Correspondingly, somatomedin levels in 12 untreated hypothyroid patients (0.82 ± 0.04) were significantly less than in normals (P < 0.01) and increased from 0.77 ± 0.09 to 1.14 ± 0.13 (P < 0.05) in 4 patients on replacement therapy. In conclusion: somatomedin levels rise when thyroid hormones are present in excess, and fall when these are deficient. This suggests that thyroid hormones are important regulators of somatomedin levels.

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