scholarly journals Eldecalcitol increases bone mass in patients with Turner syndrome who have insufficient bone mass acquisition after estrogen replacement therapy

2018 ◽  
Vol 65 (6) ◽  
pp. 629-638 ◽  
Author(s):  
Taku Tsuburai ◽  
Tomomi Nakamura ◽  
Hiromi Yoshikata ◽  
Etsuko Miyagi ◽  
Hideya Sakakibara
Keyword(s):  
Bone Mass ◽  
Replacement Therapy ◽  
Turner Syndrome ◽  
Estrogen Replacement Therapy ◽  
Estrogen Replacement

scholarly journals Efficacy of estrogen replacement therapy (ERT) on uterine growth and acquisition of bone mass in patients with Turner syndrome

2015 ◽  
Vol 62 (11) ◽  
pp. 965-970 ◽  
Author(s):  
Tomomi Nakamura ◽  
Taku Tsuburai ◽  
Aya Tokinaga ◽  
Izumi Nakajima ◽  
Reiko Kitayama ◽  
...  
Keyword(s):  
Bone Mass ◽  
Replacement Therapy ◽  
Turner Syndrome ◽  
Estrogen Replacement Therapy ◽  
Estrogen Replacement ◽  
Uterine Growth

Effect of estrogen replacement therapy on bone and cardiovascular outcomes in women with turner syndrome: a systematic review and meta-analysis

Endocrine ◽  
2016 ◽  
Vol 55 (2) ◽  
pp. 366-375 ◽  
Author(s):  
Dahima Cintron ◽  
Rene Rodriguez-Gutierrez ◽  
Valentina Serrano ◽  
Paula Latortue-Albino ◽  
Patricia J Erwin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Replacement Therapy ◽  
Turner Syndrome ◽  
Estrogen Replacement Therapy ◽  
Meta Analysis ◽  
Cardiovascular Outcomes ◽  
Estrogen Replacement

scholarly journals Prediction of Pubertal Growth at Start of Estrogen Replacement Therapy in Turner Syndrome

2008 ◽  
Vol 17 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Toshiaki Tanaka ◽  
Reiko Horikawa ◽  
Yasuhiro Naiki ◽  
Susumu Yokoya ◽  
Mari Satoh
Keyword(s):  
Replacement Therapy ◽  
Turner Syndrome ◽  
Estrogen Replacement Therapy ◽  
Estrogen Replacement ◽  
Pubertal Growth

92164606 Effect of estrogen replacement therapy on bone mineral content in girls with Turner syndrome

Maturitas ◽  
1992 ◽  
Vol 15 (3) ◽  
pp. 255-256 ◽  
Author(s):  
S. Mora ◽  
G. Weber ◽  
M. Pia Guarneri ◽  
G. Nizzoli ◽  
D. Pasolini ◽  
...  
Keyword(s):  
Bone Mineral Content ◽  
Replacement Therapy ◽  
Turner Syndrome ◽  
Bone Mineral ◽  
Estrogen Replacement Therapy ◽  
Mineral Content ◽  
Estrogen Replacement

scholarly journals Uterine Development During Induced Puberty in Girls with Turner Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Monika Obara-Moszynska ◽  
Lukasz Dzialach ◽  
Barbara Rabska-Pietrzak ◽  
Marek Niedziela ◽  
Karina Kapczuk
Keyword(s):  
Replacement Therapy ◽  
Turner Syndrome ◽  
Estrogen Replacement Therapy ◽  
Pubertal Development ◽  
Healthy Population ◽  
Two Dimensional ◽  
Estrogen Replacement ◽  
Control Groups ◽  
Uterine Growth ◽  
Uterine Volume

ObjectiveMost girls and women with Turner syndrome (TS) require estrogen replacement therapy (ERT) to initiate or maintain pubertal development. Most likely, the most fundamental effect of ERT in hypogonadism is the promotion of uterine growth. The optimal ERT model is still being discussed. The present study aimed to assess uterine size in girls with TS in the prepubertal state during and after the induction of puberty and compare it to a healthy population.MethodsThe analysis encompassed 40 TS girls. The prepubertal and postpubertal control groups contained 20 healthy girls each. All patients with TS were treated with 17-ß estradiol. Uterine imaging was performed with two-dimensional (2D) transabdominal ultrasound. The uterine volume (UV) and fundocervical antero-posterior ratio (FCR) were calculated in patients with TS before the pubertal induction, after 6-12 months of estrogen replacement therapy (ERT), after ≥ 36 months of ERT or ≥ 12 months after menarche.ResultsThe average age of TS patients at estrogen introduction and at the last control visit, when the uterus was considered mature, was 12.9 years and 16.1 years, respectively. The UV in patients with TS at the beginning of ERT was 1.55 ± 1.22 cm3 and was not significantly different from the UV in the prepubertal controls. The mature UV in patients with TS was 31.04 ± 11.78 cm3 and was significantly smaller than the UV of the postpubertal controls (45.68 ± 12.51 cm3, p<0.001). The FCR in girls with TS did not differ significantly from that in the prepubertal and postpubertal control groups, respectively. No prognostic factors could be established for the final UV. By the last control visit, thelarche had advanced in most patients to Tanner 4 and 5 (37.5% and 40%, respectively).ConclusionsBefore the onset of ERT, patients with TS have a uterus similar in size to that in prepubertal healthy girls. Pubertal induction in patients with TS causes a significant increase in the UV that is detectable after 6-12 months of ERT. The mature uterus is smaller in patients with TS than in the age-matched healthy population.

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