Effects of Dietary Calcium and Phosphorus on the Steady State Levels of some Components of the Vitamin D Endocrine System

Background/Objectives: Calcium and vitamin D are important for bone health. We compared 24-hour urinary calcium-excretion (Uca/24hrs), during dietary calcium steady-state condition, for different calcium-sources and effects of vitamin D, age and sex. Subjects/Methods: Fifty-two healthy pre- and postmenopausal women and men completed the regimens: placebo, calcium carbonate (400mg) +18μg vitamin D, calcium carbonate (400mg) +38μg vitamin D and 400mg calcium phosphate (milk). Uca/24hrs was measured during dietary calcium steady state as a surrogate measure of calcium-absorption. Serum-calcium, parathyroid hormone (PTH), 25-hydroxy-vitamin D, Procollagen Type 1 N-terminal Pro- Peptide (P1NP) and C-terminal Telopeptide of type 1 collagen (CTX) were measured. Results: Mean daily intake of calcium for the study group ± SD was 1105 ±396 mg. Mean-Uca ± SD: placebo 5.19 ± 2.04 mmol/24hrs, milk 5.88 ± 2.39 mmol/24hrs, (CaCO3+D) 6.19 ± 2.34 mmol/24hrs and (CaCO3 + DD) 6.26 ± 2.32 mmol/day. Uca were higher for all regimens compared to placebo (p <0.001), no difference was found between regimens. CTX was lower during all regimens compared to placebo (p <0.001): placebo 450 ± 243 μg/L, Milk 377 ± 248 μg/L, (CaCO3+D) 392 ± 266 μg/L and (CaCO3+DD) 361 ± 232 μg/L. Conclusions: Uca was higher during supplementation with calcium compared to placebo. Supplementation with calcium reduced bone resorption significantly without effecting PTH. Menopausal status, sex and supplement with vitamin d demonstrated no effect on calcium excretion.

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Effect of dietary calcium and phosphorus on intestinal calcium absorption and vitamin D metabolism

Archives of Biochemistry and Biophysics ◽

10.1016/0003-9861(78)90367-3 ◽

1978 ◽

Vol 188 (1) ◽

pp. 145-156 ◽

Cited By ~ 41

Author(s):

M.L. Ribovich ◽

H.F. DeLuca

Keyword(s):

Vitamin D ◽

Calcium Absorption ◽

Dietary Calcium ◽

Intestinal Calcium Absorption ◽

Vitamin D Metabolism ◽

Calcium And Phosphorus

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Interrelationships Between the Key Elements of the Vitamin D Endocrine System: 25-OH-D3-1-Hydroxylase, Serum Calcium and Phosphorus Levels, Intestinal 1,25(OH)2D3, and Intestinal Calcium Binding Protein

Advances in Experimental Medicine and Biology - Phosphate Metabolism ◽

10.1007/978-1-4613-4217-5_23 ◽

1977 ◽

pp. 211-231 ◽

Cited By ~ 6

Author(s):

Anthony W. Norman ◽

Ernest J. Friedlander ◽

Helen Henry

Keyword(s):

Vitamin D ◽

Serum Calcium ◽

Calcium Binding ◽

Binding Protein ◽

Endocrine System ◽

Calcium Binding Protein ◽

Calcium And Phosphorus ◽

Phosphorus Levels

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Ectopic transcription of the parathyroid hormone gene in lymphocytes, lymphoblastoid cells and tumour tissue

Journal of Endocrinology ◽

10.1677/joe.0.1350249 ◽

1992 ◽

Vol 135 (2) ◽

pp. 249-256 ◽

Cited By ~ 1

Author(s):

O. Handt ◽

A. Reis ◽

J. Schmidtke

Keyword(s):

Vitamin D ◽

Polymerase Chain Reaction ◽

Steady State ◽

Parathyroid Hormone ◽

Phorbol Esters ◽

Rat Tissues ◽

Chain Reaction ◽

Lymphoblastoid Cells ◽

Steady State Levels ◽

Polymerase Chain

ABSTRACT Using reverse transcription polymerase chain reaction, steady-state levels of parathyroid hormone (PTH) mRNA were investigated in a number of human, bovine and rat tissues. Transcripts were consistently detected in parathyroid glands as well as in lymphocytes, lymphoblastoid cells and several tumours. Levels of transcription were not measurably increased in lymphoblastoid cells and tumour tissues compared with unstimulated peripheral lymphocytes. The level of 'ectopic' transcription of the PTH gene in lymphoblastoid cells appeared to be resistant to the administration of both vitamin D and phorbol esters. Journal of Endocrinology (1992) 135, 249–256

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