scholarly journals Experimental Study of the Laser-Induced Oxyhemoglobin Photodissociation in Cutaneous Blood Vessels

2015 ◽  
Vol 42 (2) ◽  
pp. 42-48
Author(s):  
Alexander Gisbrecht ◽  
S. Mamilov
Keyword(s):  
Experimental Study ◽  
Experimental Investigation ◽  
Oxygen Saturation ◽  
Blood Vessels ◽  
Optical Method ◽  
Tissue Oxygenation ◽  
Biomedical Application ◽  
Local Oxygen ◽  
Cutaneous Blood

Summary A new optical method for reduction of local tissue hypoxia is proposed. It is shown that this method of phototherapy allows the control of a local oxygen concentration in tissue. Different aspects of biomedical application of this phenomenon are discussed. The results of in vivo experimental investigation of the laser-induced photodissociation of oxyhemoglobin in cutaneous blood vessels and its role in tissue oxygenation are presented. The rates of oxygen saturation SpO2 in blood and their dependence on the wavelength of the transcutaneous laser irradiation have been experimentally measured.

scholarly journals In vivo results using photothermal tomography for imaging cutaneous blood vessels

2003 ◽  
Author(s):  
Bernard Choi ◽  
Boris Majaron ◽  
Gracie Vargas ◽  
Byungjo Jung ◽  
Oliver F. Stumpp ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Cutaneous Blood

scholarly journals In Vivo Assessment of Hypoxia Levels in Pancreatic Tumors Using a Dual-Modality Ultrasound/Photoacoustic Imaging System

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 668
Author(s):  
Yuhling Wang ◽  
De-Fu Jhang ◽  
Chia-Hua Tsai ◽  
Nai-Jung Chiang ◽  
Chia-Hui Tsao ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Oxygen Saturation ◽  
Pancreatic Tumor ◽  
Tissue Oxygenation ◽  
Imaging System ◽  
Tissue Oxygen Saturation ◽  
Functional Information ◽  
Tissue Oxygen ◽  
Dual Modality

Noninvasive anatomical and functional imaging has become an essential tool to evaluate tissue oxygen saturation dynamics in preclinical or clinical studies of hypoxia. Our dual-wavelength technique for photoacoustic (PA) imaging based on the differential absorbance spectrum of oxyhemoglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb) can quantify tissue oxygen saturation using the intrinsic contrast property. PA imaging of tissue oxygen saturation can be used to monitor tumor-related hypoxia, which is a particularly relevant functional parameter of the tumor microenvironment that has a strong influence on tumor aggressiveness. The simultaneous acquisition of anatomical and functional information using dual-modality ultrasound (US) and PA imaging technology enhances the preclinical applicability of the method. Here, the developed dual-modality US/PA system was used to measure relative tissue oxygenation using the dual-wavelength technique. Tissue oxygen saturation was quantified in a pancreatic tumor mouse model. The differences in tissue oxygenation were detected by comparing pancreatic samples from normal and tumor-bearing mice at various time points after implantation. The use of an in vivo pancreatic tumor model revealed changes in hypoxia at various stages of tumor growth. The US/PA imaging data positively correlated with the results of immunohistochemical staining for hypoxia. Thus, our dual-modality US/PA imaging system can be used to reliably assess and monitor hypoxia in pancreatic tumor mouse models. These findings enable the use of a combination of US and PA imaging to acquire anatomical and functional information on tumor growth and to evaluate treatment responses in longitudinal preclinical studies.

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