Clinical usefulness of drug-laboratory test interaction alerts: a multicentre survey

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jasmijn A. van Balveren ◽  
Wilhelmine P. H. G. Verboeket-van de Venne ◽  
Carine J. M. Doggen ◽  
Anne S. Cornelissen ◽  
Lale Erdem-Eraslan ◽  
...  
Keyword(s):  
Decision Making ◽  
Laboratory Test ◽  
Medical Decision Making ◽  
Clinical Laboratory ◽  
Medical Decision ◽  
Test Results ◽  
Clinical Value ◽  
Laboratory Test Results ◽  
Care Surgery ◽  
To Receive

Abstract Objectives Knowledge of possible drug-laboratory test interactions (DLTIs) is important for the interpretation of laboratory test results. Failure to recognize these interactions may lead to misinterpretation, a delayed or erroneous diagnosis, or unnecessary extra diagnostic tests or therapy, which may harm patients. The aim of this multicentre survey was to evaluate the clinical value of DLTI alerts. Methods A survey was designed with six predefined clinical cases selected from the clinical laboratory practice with a potential DLTI. Physicians from several departments, including internal medicine, cardiology, intensive care, surgery and geriatrics in six participating hospitals were recruited to fill in the survey. The survey addressed their knowledge of DLTIs, motivation to receive an alert and opinion on the potential influence on medical decision making. Results A total of 210 physicians completed the survey. Of these respondents 93% had a positive attitude towards receiving DLTI alerts; however, the reported value differed per case and per respondent’s background. In each clinical case, medical decision making was influenced as a consequence of the reported DLTI message (ranging from 3 to 45% of respondents per case). Conclusions In this multicentre survey, most physicians stated DLTI messages to be useful in laboratory test interpretation. Medical decision making was influenced by reporting DLTI alerts in each case. Alerts should be adjusted according to the needs and preferences of the receiving physicians.

scholarly journals Cellular Telephone-Aided Real-Time Reporting System for Emergency Laboratory Test Results

2002 ◽  
Vol 7 (4) ◽  
pp. 75-80
Author(s):  
Mitsuhiko Sugimachi ◽  
Seiji Kawasaki ◽  
Fumio Nagumo ◽  
Jutaro Tadano
Keyword(s):  
Laboratory Test ◽  
Real Time ◽  
Reporting System ◽  
Clinical Laboratory ◽  
Test Results ◽  
Timely Manner ◽  
Cellular Telephone ◽  
Laboratory Test Results ◽  
To Receive ◽  
Test Result

The authors established a system for real-time reporting of clinical laboratory test results utilizing the mailing function of a cellular telephone service. The reporting system is composed of systems for sample transportation and automatic analysis, verification of test results, and reporting of test results. The introduction of the system has completely eliminated time delays at all stages of the laboratory testing process from start of testing to reporting of the test result. This has enabled doctors to receive test results in a timely manner wherever they are and to respond promptly to the patient condition.

Herbal Remedies: Effects on Clinical Laboratory Tests

2006 ◽  
Vol 130 (4) ◽  
pp. 521-528 ◽  
Author(s):  
Amitava Dasgupta ◽  
David W. Bernard
Keyword(s):  
Chinese Medicine ◽  
Laboratory Test ◽  
Alternative Medicine ◽  
Clinical Laboratory ◽  
Herbal Remedies ◽  
Test Results ◽  
Abnormal Laboratory ◽  
St John's Wort ◽  
Laboratory Test Results ◽  
Laboratory Results

AbstractContext.—Complementary and alternative medicine (herbal medicines) can affect laboratory test results by several mechanisms.Objective.—In this review, published reports on effects of herbal remedies on abnormal laboratory test results are summarized and commented on.Data Sources.—All published reports between 1980 and 2005 with the key words herbal remedies or alternative medicine and clinical laboratory test, clinical chemistry test, or drug-herb interaction were searched through Medline. The authors' own publications were also included. Important results were then synthesized.Data Synthesis.—Falsely elevated or falsely lowered digoxin levels may be encountered in a patient taking digoxin and the Chinese medicine Chan Su or Dan Shen, owing to direct interference of a component of Chinese medicine with the antibody used in an immunoassay. St John's wort, a popular herbal antidepressant, increases clearance of many drugs, and abnormally low cyclosporine, digoxin, theophylline, or protease inhibitor concentrations may be observed in a patient taking any of these drugs in combination with St John's wort. Abnormal laboratory results may also be encountered owing to altered pathophysiology. Kava-kava, chaparral, and germander cause liver toxicity, and elevated alanine aminotransferase, aspartate aminotransferase, and bilirubin concentrations may be observed in a healthy individual taking such herbal products. An herbal product may be contaminated with a Western drug, and an unexpected drug level (such as phenytoin in a patient who never took phenytoin but took a Chinese herb) may confuse the laboratory staff and the clinician.Conclusions.—Use of alternative medicines may significantly alter laboratory results, and communication among pathologists, clinical laboratory scientists, and physicians providing care to the patient is important in interpreting these results.

Terminology of cardiac troponin assays and data censoring

2017 ◽  
Vol 55 (11) ◽  
Author(s):  
Petr Jarolim
Keyword(s):  
Laboratory Test ◽  
Cardiac Troponin ◽  
Clinical Laboratory ◽  
Clinical Information ◽  
Reference Population ◽  
Test Results ◽  
Clinical Laboratory Test ◽  
Laboratory Test Results ◽  
Data Censoring ◽  
Selection Of

AbstractWe discuss the sensitivity terminology of cardiac troponin assays and its dependence on the selection of the reference population. In addition, the need for reasonable censoring of clinical laboratory test results is contrasted with potential loss of valuable clinical information.

Incorporating Uncertainty Into Medical Decision Making: An Approach to Unexpected Test Results

2009 ◽  
Vol 29 (1) ◽  
pp. 116-124 ◽  
Author(s):  
Matt T. Bianchi ◽  
Brian M. Alexander ◽  
Sydney S. Cash
Keyword(s):  
Decision Making ◽  
Medical Decision Making ◽  
Medical Decision ◽  
Test Results

User-Centered System Design for Communicating Clinical Laboratory Test Results (Preprint)

2020 ◽  
Author(s):  
Zhan Zhang ◽  
Lukas Kmoth ◽  
Xiao Luo ◽  
Zhe He
Keyword(s):  
Laboratory Test ◽  
User Study ◽  
Clinical Laboratory ◽  
Interactive System ◽  
User Evaluation ◽  
Test Results ◽  
Patient Centered ◽  
Laboratory Test Results ◽  
Study Results ◽  
User Centered

BACKGROUND Personal clinical data such as laboratory test results are increasingly being made available to patients via patient portals. However, laboratory test results are presented via portals in a way that is hard for patients to interpret and use. Furthermore, the indications of test results may vary among patients with different characteristics and medical contexts. To date, little is known about how to design patient-centered technology to facilitate the interpretation of test results. OBJECTIVE The aim of this study is to explore design considerations for an interactive system to support patient-centered communication and comprehension of laboratory test results as well as discussions between patient and health providers. METHODS We conducted a user-centered, multi-component design exploration study, consisting of user studies, iterative prototype design, and user evaluation, to explore design concepts and considerations that are useful for supporting patients not only viewing but also interpreting and acting upon laboratory test results. RESULTS The user study results informed the iterative design of a system prototype, including several interactive features: 1) using graphical representations and clear takeaway messages to convey the concerning nature of the result, 2) enabling users to annotate laboratory test reports, 3) clarifying medical jargon using non-technical verbiage and allowing users to interact with the medical terms (e.g., save, favorite, sort, etc.), and 4) providing pertinent and reliable information to help patients comprehend test results within their medical context. Through an initial user evaluation with 8 patients, results show that the new patient-facing system was perceived useful in not only presenting laboratory results to patients in a meaningful way but also facilitating in situ patient-provider interaction. CONCLUSIONS We draw on our findings to discuss design implications for supporting patient-centered communication of laboratory test results, and how to make the technology support informative, trustworthy, and empathetic.

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