Genotyping Method for Point Mutation Detection in the Endothelial Nitric Oxide Synthase Exon 7 Using Fluorescent Probes. Clinical Validation in Systemic Sclerosis Patients

2001 ◽  
Vol 39 (3) ◽  
Author(s):  
Maria L. Biondi ◽  
Bianca Marasini ◽  
Simona Leviti ◽  
Olivia Turri ◽  
Mara Bernini ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Systemic Sclerosis ◽  
Nitric Oxide Synthase ◽  
Point Mutation ◽  
Fluorescent Probes ◽  
Endothelial Nitric Oxide Synthase ◽  
Mutation Detection ◽  
Clinical Validation ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

AB0504 Vascular differences associated to genetic polymorphisms of endothelial nitric oxide synthase in mexican patients with systemic sclerosis.

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A942.3-A942
Author(s):  
M. P. D. P. Cruz-Dominguez ◽  
O. Vera-Lastra ◽  
M. A. Martinez-Godinez ◽  
A. Miliar-Garcia ◽  
D. H. Montes-Cortes ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Systemic Sclerosis ◽  
Nitric Oxide Synthase ◽  
Genetic Polymorphisms ◽  
Endothelial Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Mexican Patients

Polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in systemic sclerosis

2005 ◽  
Vol 118 (8) ◽  
pp. 907-911 ◽  
Author(s):  
Shervin Assassi ◽  
Maureen D. Mayes ◽  
Terry McNearney ◽  
Michael Fischbach ◽  
John D. Reveille ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Systemic Sclerosis ◽  
Nitric Oxide Synthase ◽  
Angiotensin Converting Enzyme ◽  
Endothelial Nitric Oxide Synthase ◽  
Converting Enzyme ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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