Impact of Truncated Area Under the Curve on Failed Bioequivalence Studies: A Computer Simulation Analysis

Author(s):  
I. Mahmood
1999 ◽  
Author(s):  
R. Wade Allen ◽  
Theodore J. Rosenthal ◽  
David H. Klyde ◽  
Jeffrey R. Hogue

2006 ◽  
Vol 18 (Supplement) ◽  
pp. 123-123
Author(s):  
AOI OZAKI ◽  
KAZUYUKI MITSUI ◽  
SHIN INADA ◽  
NITARO SHIBATA ◽  
MARK R. BOYETT ◽  
...  

Author(s):  
Y. Ito ◽  
H. Komizo ◽  
T. Meguro ◽  
Y. Daido ◽  
I. Umebu

1994 ◽  
Vol 42 (4) ◽  
pp. 467 ◽  
Author(s):  
OJ Reichman ◽  
E Roberts

A number of hypotheses have been proposed to explain the mechanisms that promote coexistence among sympatric rodents in North American deserts. In an effort to determine how the distribution of seeds influences foraging patterns and coexistence in a three-species community of heteromyid rodents, we developed a computer simulation model that determines the efficiency of foraging for animals of different sizes. Specifically, the simulation determines how long it would take a forager to gather sufficient energy for 24 h if the animal stopped at seed patches of certain densities. The analyses were conducted for naturally occurring seed distributions and densities, for simulated normal and uniform distributions at natural densities, and for natural distributions at seed densities one-third those known to occur naturally. The results indicate that, under natural distributions and densities, each of the three species possessed unique optima for utilising seed patches of different density. However, when either the seed distribution or density differed from actual values, all three species had identical optima. The implications of these results for promoting coexistence are discussed.


1988 ◽  
Vol 27 (Part 2, No. 3) ◽  
pp. L444-L447 ◽  
Author(s):  
Yoshihide Kimura ◽  
Hee Jae Kang ◽  
Ryuichi Shimizu

2005 ◽  
Vol 42 (3) ◽  
pp. 742-751 ◽  
Author(s):  
Xilin Lu ◽  
Peizhen Li ◽  
Bo Chen ◽  
Yueqing Chen

A three-dimensional finite element analysis of the soil–pile–structure interaction system is presented in this paper. The analysis is based on data from shaking table model tests made in the State Key Laboratory for Disaster Reduction in Civil Engineering, Tongji University, China. The general finite element program ANSYS is used in the analysis. The surface-to-surface contact element is taken into consideration for the nonlinearity state of the soil–pile interface, and an equivalent linear model is used for soil behavior. A comparison of the results of the finite element analysis with the data from the shaking table tests is used to validate the computational model. Furthermore, the reliability of the test result is also verified by the simulation analysis. It shows that separation, closing, and sliding exist between the pile foundation and the soil. The distribution of the amplitude of strains in the pile, the amplitude of contact pressure, and the amplitude of sliding at the soil–pile interface are also discussed in detail in this paper.Key words: soil–pile–structure interaction, shaking table model test, computer simulation, ANSYS program.


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