Baker’s yeast catalyzed one-pot synthesis of bioactive 2-[benzylidene(or pyrazol-4-ylmethylene)hydrazono]-1,3-thiazolidin-4-one-5-yl-acetic acids
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One Pot
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Abstract An efficient and simple one-pot protocol has been developed for synthesis of substituted derivatives of 2-hydrazono-4-thiazolidinone-5-acetic acids 4a–j and 6a–g by cyclocondensation of aryl/pyrazolyl aldehyde, thiosemicarbazide and maleic anhydride in acetonitrile in the presence of readily available whole cell biocatalyst, baker’s yeast (Saccharomyces cerevisiae). The reaction is enhanced by ultrasonication.
2017 ◽
Vol 47
(5)
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pp. 409-420
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1981 ◽
Vol 31
(1)
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pp. 290-294
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1974 ◽
Vol 8
(4)
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pp. 195-200
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1998 ◽
Vol 120
(15)
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pp. 3541-3548
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