Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia

2011 ◽  
Vol 24 (9-10) ◽  
Author(s):  
Yusuf Unal Sarikabadayi ◽  
Ozge Aydemir ◽  
Cumhur Aydemir ◽  
Nurdan Uras ◽  
Serife Suna Oguz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Umbilical Cord ◽  
Infants Of Diabetic Mothers ◽  
Maternal Hyperglycemia ◽  
Diabetic Mothers

scholarly journals 643 Elevated Acetoacetate, Oxidative Stress and Mcp-1 Levels in Cord Blood of Infants of Diabetic Mothers

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A186-A187
Author(s):  
D. Kurepa ◽  
A. Pramanik ◽  
L. Groome ◽  
J. Bocchini ◽  
S. Jain
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

The relationship between the oxidative stress and the cardiac hypertrophy in infants of diabetic mothers

2015 ◽  
Vol 109 (1) ◽  
pp. 104-109 ◽  
Author(s):  
Sevilay Topcuoglu ◽  
Guner Karatekin ◽  
Taner Yavuz ◽  
Didem Arman ◽  
Ayşem Kaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Hypertrophy ◽  
Infants Of Diabetic Mothers ◽  
The Relationship ◽  
Diabetic Mothers

Umbilical Cord Glycosylated Hemoglobin in Infants of Diabetic Mothers: Relationships to Neonatal Hypoglycemia, Macrosomia, and Cord Serum C-Peptide

Diabetes Care ◽  
1982 ◽  
Vol 5 (6) ◽  
pp. 566-570 ◽  
Author(s):  
J. M. Sosenko ◽  
J. L. Kitzmiller ◽  
R. Fluckiger ◽  
S. W. H. Loo ◽  
D. M. Younger ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Glycosylated Hemoglobin ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Cord Serum ◽  
Diabetic Mothers

Umbilical cord androgens in infants of diabetic mothers

1997 ◽  
Vol 259 (3) ◽  
pp. 139-141 ◽  
Author(s):  
O. Gemer ◽  
J. Sevillia ◽  
J. Zalis ◽  
S. Segal
Keyword(s):  
Umbilical Cord ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers

scholarly journals Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

2012 ◽  
Vol 36 (2) ◽  
pp. 71-75
Author(s):  
Mst Nurun Nahar Begum ◽  
M Quamrul Hassan ◽  
Kishwar Azad
Keyword(s):  
Blood Glucose ◽  
Child Health ◽  
Umbilical Cord ◽  
Clinical Characteristics ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Peptide Level ◽  
The Relationship ◽  
Diabetic Mothers

Objective: To examine the relationship between umbilical cord C-peptide and risk of hypoglycemia in infants of diabetic mothers. Method: Sixty neonates born to diabetic mothers were studied in BIRDEM hospital. Thirty infants who developed hypoglycemia at any time during the first 24 hours of age were considered as cases. Another 30 infants who did not develop hypoglycemia during the first 24 hours were considered as controls. Umbilical cord C-peptide levels were measured in both groups. All babies were screened for hypoglycemia at 4, 6, 8, 12, 18 and 24 hours of life. Blood glucose value of less than 2.6 mmol/l was considered as hypoglycemia. Results: Clinical characteristics of cases and controls and their mothers did not show any significant difference. In 73.3% of cases hypoglycemia was detected by 6 hours of age. Most babies were asymptomatic (93.3%). It was found that IDMs who developed hypoglycemia had significantly higher cord C-peptide level at birth compared to those who remained normoglycemic (4.57±2.50 vs. 2.81± 2.11 ng/ml, P= 0.005). That means, there is significant association between raised level of cord C-peptide and hypoglycemia in IDMs. Conclusion: Hypoglycemia in infants of diabetic mothers associated with raised cord blood C-peptide levels. DOI: http://dx.doi.org/10.3329/bjch.v36i2.13082 Bangladesh J Child Health 2012; Vol 36 (2): 71-75

scholarly journals Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers

2020 ◽  
Author(s):  
Ahlam Saber ◽  
Magdy Mohamed ◽  
Abdelrahim Sadek ◽  
Ramadan Mahmoud
Keyword(s):  
Umbilical Cord ◽  
Diabetes Control ◽  
P Value ◽  
Maternal Weight ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Serial Serum ◽  
Diabetic Mothers

Abstract Background: Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia.Material and methods: UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected.Results: In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value= 0.43). The hypoglycemia peak occurred within the first 3 hours of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96) compared to normoglycemic babies (HbA1C 6.11 ± 0.38), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005).Conclusion: Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

scholarly journals Role of umbilical cord C-peptide levels in early prediction of hypoglycemia in infants of diabetic mothers

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ahlam M. Saber ◽  
Magdy A. Mohamed ◽  
Abdelrahim A. Sadek ◽  
Ramadan A. Mahmoud
Keyword(s):  
Umbilical Cord ◽  
Diabetes Control ◽  
P Value ◽  
Maternal Weight ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Serial Serum ◽  
Diabetic Mothers

Abstract Background Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia. Material and methods UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected. Results In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value = 0.43). The hypoglycemia peak occurred within the first 3 h of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96%) compared to normoglycemic babies (HbA1C 6.11 ± 0.38%), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005). Conclusion Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

Umbilical cord androgens in infants of diabetic mothers

1997 ◽  
Vol 259 (3) ◽  
pp. 139-141
Author(s):  
O. Gemer ◽  
J. Sevillia ◽  
J. Zalis ◽  
S. Segal
Keyword(s):  
Umbilical Cord ◽  
Infants Of Diabetic Mothers ◽  
Diabetic Mothers
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