scholarly journals Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

2012 ◽  
Vol 36 (2) ◽  
pp. 71-75
Author(s):  
Mst Nurun Nahar Begum ◽  
M Quamrul Hassan ◽  
Kishwar Azad
Keyword(s):  
Blood Glucose ◽  
Child Health ◽  
Umbilical Cord ◽  
Clinical Characteristics ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Peptide Level ◽  
The Relationship ◽  
Diabetic Mothers

Objective: To examine the relationship between umbilical cord C-peptide and risk of hypoglycemia in infants of diabetic mothers. Method: Sixty neonates born to diabetic mothers were studied in BIRDEM hospital. Thirty infants who developed hypoglycemia at any time during the first 24 hours of age were considered as cases. Another 30 infants who did not develop hypoglycemia during the first 24 hours were considered as controls. Umbilical cord C-peptide levels were measured in both groups. All babies were screened for hypoglycemia at 4, 6, 8, 12, 18 and 24 hours of life. Blood glucose value of less than 2.6 mmol/l was considered as hypoglycemia. Results: Clinical characteristics of cases and controls and their mothers did not show any significant difference. In 73.3% of cases hypoglycemia was detected by 6 hours of age. Most babies were asymptomatic (93.3%). It was found that IDMs who developed hypoglycemia had significantly higher cord C-peptide level at birth compared to those who remained normoglycemic (4.57±2.50 vs. 2.81± 2.11 ng/ml, P= 0.005). That means, there is significant association between raised level of cord C-peptide and hypoglycemia in IDMs. Conclusion: Hypoglycemia in infants of diabetic mothers associated with raised cord blood C-peptide levels. DOI: http://dx.doi.org/10.3329/bjch.v36i2.13082 Bangladesh J Child Health 2012; Vol 36 (2): 71-75

scholarly journals Influence of Maternal Glycemic Status (HbA1c) at Delivery and Risk of Hypoglycemia in Infants of Diabetic Mothers

2012 ◽  
Vol 2 (2) ◽  
pp. 84-88
Author(s):  
Mst Nurun Nahar Begum ◽  
M Quamrul Hassan ◽  
Maherun Nessa ◽  
Kishwar Azad
Keyword(s):  
Blood Glucose ◽  
Hba1c Level ◽  
Glycosylated Hemoglobin ◽  
Good Control ◽  
Significant Negative Correlation ◽  
Glycemic Status ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Control Study ◽  
Diabetic Mothers

Objective: To examine the influence of maternal HbA1c level at delivery and risk of hypoglycemia in infants of diabetic mothers. Method: This case-control study was done with sixty neonates born to diabetic mothers in BIRDEM hospital. Out of sixty neonates, 30 neonates who developed hypoglycemia during the first 24 hours of age were considered as cases and another 30 neonates who did not develop hypoglycemia during the first 24 hours were considered as controls. Maternal glycemic status was examined by measurement of Glycosylated hemoglobin (HbA1c) and level of <6 % considered good control. Babies were screened for hypoglycemia at birth, then 4, 6, 8, 12, 18 and 24 hours of life. Blood glucose value of less than 2.6 mmol/l was considered as hypoglycemia. Results: Clinical characteristics of newborns and their mothers of cases and controls did not show any significant difference. In majority of cases (73.3%) hypoglycemia was detected by 6 hours of age. Most of babies were asymptomatic (93.3%). Majority of mothers (76.7%) in controls and 46.7% of were in good glycemic controls (HbA1c <6%). The mean HbA1c level of mothers of cases was significantly higher than that of control mothers (6.02 ± 0.98 vs 5.44 ± 0.78; P = 0.014) and significant negative correlation between maternal HbA1c and blood glucose level of neonates ( r=0.422 p= 0.001). Conclusion: There is an association between maternal HbA1c level and neonatal hypoglycemia in infants of diabetic mothers.DOI: http://dx.doi.org/10.3329/birdem.v2i2.12308 (Birdem Med J 2012; 2(2): 84-88)

Blood Glucose and Plasma Amino Acid Concentrations in Infants of Diabetic Mothers

PEDIATRICS ◽  
1978 ◽  
Vol 61 (1) ◽  
pp. 77-82
Author(s):  
Gyula Soltész ◽  
Károly Schultz ◽  
Julius Mestyán ◽  
Imre Horváth
Keyword(s):  
Amino Acids ◽  
Blood Glucose ◽  
Amino Acid ◽  
Blood Glucose Concentration ◽  
Birth Asphyxia ◽  
Plasma Amino Acid ◽  
Total Plasma ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Diabetic Mothers

Postnatal blood glucose and individual plasma free amino acid levels were measured in 14 newborn infants of diabetic mothers. All infants had a significantly lower blood glucose concentration than normal controls but no significant correlation was observed between the blood glucose values and any of the amino acids determined. As regards the quantitative and qualitative changes of the plasma aminogram, the total concentration of amino acids and the level of a few individual amino acids (glycine, alanine, taurine, and valine) were significantly elevated in full-term babies. However, no significant difference was found in the total plasma concentration of amino acids between premature infants of diabetic mothers and premature control infants, but the plasma alanine level was higher in the former. It is of interest that total plasma amino acid, alanine, and glycine levels were elevated in the asphyxiated babies. This suggests that the postnatal hyperaminoacidemia observed in infants of diabetic mothers was due to birth asphyxia rather than to impaired gluconeogenesis. The possible role of a defective gluconeogenesis in the etiology of postnatal hypoglycemia in infants of diabetic mothers is not supported by these data.

Umbilical Cord Glycosylated Hemoglobin in Infants of Diabetic Mothers: Relationships to Neonatal Hypoglycemia, Macrosomia, and Cord Serum C-Peptide

Diabetes Care ◽  
1982 ◽  
Vol 5 (6) ◽  
pp. 566-570 ◽  
Author(s):  
J. M. Sosenko ◽  
J. L. Kitzmiller ◽  
R. Fluckiger ◽  
S. W. H. Loo ◽  
D. M. Younger ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Glycosylated Hemoglobin ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Cord Serum ◽  
Diabetic Mothers

scholarly journals Glycemic status of infants of diabetic mothers; a study at the Children’s Hospital and Institute of Child Health, Multan.

2021 ◽  
Vol 28 (11) ◽  
pp. 1626-1632
Author(s):  
Abdur Rehman ◽  
Waqas Imran Khan ◽  
Ahmad Iqbal Quddusi ◽  
Aashee Nadeem ◽  
Nazia Fatima ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Child Health ◽  
Cross Sectional Study ◽  
Large For Gestational Age ◽  
Cross Sectional ◽  
Infants Of Diabetic Mothers ◽  
Children's Hospital ◽  
Increased Risk ◽  
Children’S Hospital ◽  
Diabetic Mothers

Objective: To find out the frequency of hypoglycemia among infants of diabetic mothers (IDMs) and factors affecting it. Study Design: Descriptive Cross Sectional study. Setting: Department of Neonatology, The Children’s Hospital and Institute of Child Health, Multan, Pakistan. Period: September 2019 t0 June 2020. Material & Methods: A total of 186 IDMs admitted to department of neonatology during the study period were enrolled. Bed side blood glucose (BG) was measured using “Accu Chek Performa Blood Glucose Meter” at 0, 2, 4, 6, 8, 12, 18 and 24 hours of life. All IDMs (Infants of Diabetic Mothers) were labeled either gestational diabetes mellitus (GDM) or pre GDM (pre-GDM). IDMs noted to have hypoglycemia during 1st 24 hours of life were described as hypoglycemic and others were labeled as normoglycemic IDMs. Results: Hypoglycemia was noted among 77 (41.4%) IDMs. Duration of disease was significantly more among mothers of hypoglycemic infants (27.62+28.8months vs. 19.69+24.41 months, p=0.0444). Significantly more large for gestational age (LGA) IDMs were found to be hypoglycemic in comparison to normoglycaemic ones (32.5% vs. 16.5%, p=0.0110). Among a total of 77 IDMs noted to have hypoglycemia, 34 (44.1%) were born to mothers who had GDM while remaining 43 (55.9%) were born to pre-GDM mothers. Significantly more IDMs were preterm among pre-GDM mothers when compared to GDM mothers (53.5% vs. 23.5%, p=0.0077). Conclusion: Hypoglycemia is frequent problem among IDMs. Increased duration of diabetes among mothers, LGA as well as preterm IDMs are found to have significantly increased risk of developing hypoglycemia.

scholarly journals Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers

2020 ◽  
Author(s):  
Ahlam Saber ◽  
Magdy Mohamed ◽  
Abdelrahim Sadek ◽  
Ramadan Mahmoud
Keyword(s):  
Umbilical Cord ◽  
Diabetes Control ◽  
P Value ◽  
Maternal Weight ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Serial Serum ◽  
Diabetic Mothers

Abstract Background: Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia.Material and methods: UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected.Results: In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value= 0.43). The hypoglycemia peak occurred within the first 3 hours of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96) compared to normoglycemic babies (HbA1C 6.11 ± 0.38), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005).Conclusion: Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

scholarly journals Role of umbilical cord C-peptide levels in early prediction of hypoglycemia in infants of diabetic mothers

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ahlam M. Saber ◽  
Magdy A. Mohamed ◽  
Abdelrahim A. Sadek ◽  
Ramadan A. Mahmoud
Keyword(s):  
Umbilical Cord ◽  
Diabetes Control ◽  
P Value ◽  
Maternal Weight ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Serial Serum ◽  
Diabetic Mothers

Abstract Background Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia. Material and methods UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected. Results In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value = 0.43). The hypoglycemia peak occurred within the first 3 h of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96%) compared to normoglycemic babies (HbA1C 6.11 ± 0.38%), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005). Conclusion Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.

Epicardial fat thickness in infants of diabetic mothers

2021 ◽  
pp. 1-6
Author(s):  
M.M. Vela-Huerta ◽  
N. Amador-Licona ◽  
R. Domínguez-Damiá ◽  
A. Heredia-Ruiz ◽  
H.V. Orozco-Villagomez ◽  
...  
Keyword(s):  
Interventricular Septum ◽  
Left Ventricular ◽  
Epicardial Fat ◽  
Left Ventricular Ejection ◽  
Epicardial Fat Thickness ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Echocardiographic Parameters ◽  
Fat Thickness ◽  
Diabetic Mothers

BACKGROUND: Epicardial fat thickness (EFT) in adults and children has been related to the metabolic syndrome and other cardiovascular risk factors; however, scarce studies have evaluated it in infants of diabetic mothers (IDM) in whom, alterations in the thickness of the interventricular septum have been reported. This study compares the EFT in IDM versus infants of non-diabetic mothers (INDM) and its association with others echocardiographic parameters. METHODS: We performed a cross sectional study in 93 infants (64 IDM and 29 INDM). To evaluate EFT dimensions, an echocardiogram was performed within the first 24h of extrauterine life in both groups. In diabetic mothers, HbA1c was also determined. RESULTS: There was no significant difference in birth weight between the groups although gestational age was lower in IDM. The EFT (3.6 vs. 2.5 mm, p <  0.0001), the interventricular septum thickness (IVST) (6.2 vs. 5.2 mm, p <  0.0001) and the IVST / left ventricle posterior wall (1.3 vs. 1.1, p = 0.001) were higher in the IDM; while the left ventricular expulsion fraction [LVFE] (71.1 vs. 77.8; p <  0.0001) was lower than in the INDM, respectively. We found a positive correlation between EFT with IVST (r = 0.577; p = 0.0001), LVPW (r = 0.262; p = 0.011), IVST/LVPW index (r = 0.353; p = 0.001), and mitral integral early velocity (r = 0.313; p = 0.002), while a negative correlation with LVFE was observed (r = –0.376; p = 0.0001). CONCLUSIONS: The EFT is higher in IDM than in INDM. It was positively related with echocardiographic parameters of left ventricular thickness and negatively with left ventricular ejection function.

scholarly journals Body mass, plasma leptin, glucose, insulin and C-peptide in offspring of diabetic and non-diabetic mothers

2001 ◽  
Vol 145 (1) ◽  
pp. 53-58 ◽  
Author(s):  
L Kostalova ◽  
L Leskova ◽  
A Kapellerova ◽  
V Strbak
Keyword(s):  
Body Mass ◽  
Plasma Insulin ◽  
Tanner Stage ◽  
Strongly Correlated ◽  
C Peptide ◽  
Glucose Levels ◽  
A Prospective Study ◽  
Plasma Leptin ◽  
The Relationship ◽  
Diabetic Mothers

OBJECTIVE: The aim was to investigate the relationship between body mass index (BMI), plasma leptin, glucose, insulin and C-peptide levels in the offspring of diabetic mothers (DM) and non-diabetic healthy mothers (HM). DESIGN: Seventy-two offspring (37 girls and 35 boys, age 4-20 years) of DM were investigated in a prospective study. Those 14-16 years old (Tanner stage II-IV) were compared with age-matched offspring of HM (33 girls and 33 boys). RESULTS: BMI strongly correlated with plasma leptin concentration in the offspring of both DM and HM children. There were higher BMI and plasma leptin and glucose levels in DM than in HM children. There was no difference in plasma insulin or C-peptide levels between HM and age-matched DM children. There was a highly significant positive correlation between plasma leptin and C-peptide in boys of DM. CONCLUSIONS: The higher plasma leptin found in the offspring of DM reflects their higher BMI. A moderately high but still normal glycemia might be a preclinical sign of insulin resistance or other disturbance of glucoregulation.

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