scholarly journals Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk

2016 ◽  
Vol 50 (3) ◽  
pp. 297-307 ◽  
Author(s):  
Petra Hudler ◽  
Nina Kocevar Britovsek ◽  
Snjezana Frkovic Grazio ◽  
Radovan Komel
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Immunoblot Analysis ◽  
Dominant Model ◽  
Nucleotide Polymorphisms ◽  
Diffuse Type ◽  
Gastric Cancer Risk ◽  
Genetic Changes ◽  
Female Population ◽  
Mitotic Kinases

Abstract Background Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in gastric carcinogenesis. Single nucleotide polymorphisms (SNPs) in mitotic segregation genes could be responsible for inducing the slow process of accumulation of genetic changes, leading to genome instability. Patients and methods We performed a case-control study of polymorphisms in mitotic kinases TTK rs151658 and BUB1B rs1031963 and rs1801376 to assess their effects on gastric cancer risk. We examined the TTK abundance in gastric cancer tissues using immunoblot analysis. Results C/G genotype of rs151658 was more frequent in patients with diffuse type of gastric cancer and G/G genotype was more common in intestinal types of gastric cancers (p = 0.049). Polymorphic genotype A/A of rs1801376 was associated with higher risk for developing diffuse type of gastric cancer in female population (p = 0.007), whereas A/A frequencies were increased in male patients with subserosa tumour cell infiltration (p = 0.009). T/T genotype of rs1031963 was associated with well differentiated tumours (p = 0.035). TT+CT genotypes of rs1031963 and GG+AG genotypes of rs1801376 were significantly associated with gastric cancer risk (dominant model; OR = 2,929, 95% CI: 1.281-6.700; p = 0.017 and dominant model; OR = 0,364, 95% CI: 0.192-0.691; p = 0.003 respectively). Conclusions Our results suggest that polymorphisms in mitotic kinases TTK and BUB1B may contribute to gastric tumorigenesis and risk of tumour development. Further investigations on large populations and populations of different ethnicity are needed to determine their clinical utility.

scholarly journals Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Qing Ni ◽  
Anlai Ji ◽  
Junfeng Yin ◽  
Xiangjun Wang ◽  
Xinnong Liu
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Potential Effect ◽  
Recessive Model ◽  
Dominant Model ◽  
Common Snps ◽  
Nucleotide Polymorphisms ◽  
Gastric Cancer Risk

Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk.Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI).Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model.Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect.

scholarly journals Antioxidant-Rich Diet, GSTP1 rs1871042 Polymorphism, and Gastric Cancer Risk in a Hospital-Based Case-Control Study

2021 ◽  
Vol 10 ◽  
Author(s):  
Jimi Kim ◽  
Hyejin Kim ◽  
Jeonghee Lee ◽  
Il Ju Choi ◽  
Young-Il Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Total Phenolics ◽  
Nucleotide Polymorphisms ◽  
Gastric Cancer Risk ◽  
Glutathione S Transferase ◽  
Dietary Antioxidant ◽  
H Pylori ◽  
Gastric Cancer Patients

BackgroundChronic gastritis along with Helicobacter pylori (H. pylori) infection has been implicated in inflammatory response-related genes linked to the causation of gastric cancer. Glutathione S-transferase Pi (GSTP1) plays a role in regulating oxidative stress and detoxification against carcinogenesis. In this study, we aimed to determine whether an antioxidant-rich diet is associated with gastric cancer risk and identify how this association could be altered by GSTP1 genetic variants.MethodsThis study included 1,245 participants (415 cases and 830 controls) matched for age and sex. The dietary antioxidant capacity was estimated based on the oxygen radical absorbance capacity (ORAC) incorporated with a semiquantitative food frequency questionnaire. Five single nucleotide polymorphisms (SNPs) of GSTP1 (rs1695, rs749174, rs1871042, rs4891, and rs947895) were selected among the exome array genotype data.ResultsHigh dietary ORAC was inversely associated with gastric cancer (hydrophilic ORAC OR T3vs. T1, 95% CI = 0.57, 0.39–0.82, P = 0.004; lipophilic ORAC = 0.66, 0.45–0.95, P = 0.021; total phenolics = 0.57, 0.39–0.83, P = 0.005). The polymorphism rs1871042 increased the risk of gastric cancer (OR, 95% CI = 1.55, 1.10–2.16, P = 0.01, CT+TT vs. CC). A remarkably reduced risk of gastric cancer was observed among those who had a high dietary ORAC according to rs1871042 polymorphism (hydrophilic ORAC OR T3vs. T1, 95% CI = 0.36, 0.17–0.78, P for trend = 0.013; lipophilic ORAC = 0.58, 0.37–0.93, P for trend = 0.021; total phenolics = 0.38, 0.17–0.83, P for trend = 0.019).ConclusionsOur findings indicate that dietary ORAC intake may be inversely associated with the risk of gastric cancer altered by genetic variants of GSTP1, providing new intervention strategies for gastric cancer patients.

scholarly journals ASSOCIATION OF INTERLEUKIN-10 -1082 A/G (RS1800896) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: META-ANALYSIS OF 6,101 CASES AND 8,557 CONTROLS

2018 ◽  
Vol 55 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Abolfazl NAMAZI ◽  
Mohammad FORAT-YAZDI ◽  
Mohammadali JAFARI ◽  
Soudabeh FARAHNAK ◽  
Rezvan NASIRI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Web Of Science ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Dominant Model ◽  
Gastric Cancer Risk ◽  
Case Control Studies ◽  
Allele Model

ABSTRACT BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. METHODS: Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. RESULTS: A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95% CI=1.023-2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. CONCLUSION: These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians.

LTA 252GG andGAGenotypes are Associated with Diffuse-Type Noncardia Gastric Cancer Risk in the Japanese Population

Helicobacter ◽  
2009 ◽  
Vol 14 (6) ◽  
pp. 571-579 ◽  
Author(s):  
Gen Suzuki ◽  
Harry Cullings ◽  
Saeko Fujiwara ◽  
Shinsuke Matsuura ◽  
Takeshi Kishi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Japanese Population ◽  
Diffuse Type ◽  
Gastric Cancer Risk

scholarly journals HOTTIP polymorphism may affect gastric cancer susceptibility by altering HOTTIP expression

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Ben-gang Wang ◽  
Yi-zhi Li ◽  
Han-xi Ding ◽  
Zhi Lv ◽  
Qian Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Disease Risk ◽  
Cancer Susceptibility ◽  
Recessive Model ◽  
Eqtl Analysis ◽  
Nucleotide Polymorphisms ◽  
Gastric Cancer Risk ◽  
Specific Pcr ◽  
Non Coding Rna

Abstract Background: Non-coding RNA polymorphisms can affect disease risk and prognosis by influencing gene expression. Here, we first investigated the association between single nucleotide polymorphisms (SNPs) of long non-coding RNA (lncRNA) HOTTIP and gastric cancer risk/prognosis. Methods: A total of five HOTTIP SNPs among 627 gastric cancer cases and 935 controls were tested by Kompetitive Allele Specific PCR (KASP) assay. The functional SNPs underwent eQTL analysis and the expression of HOTTIP was assessed by quantitative RT-PCR. Results: The rs2067087 and rs3807598 SNPs of HOTTIP increased susceptibility to gastric cancer (rs2067087: dominant model, P=0.008, odds ratio (OR) = 1.35; rs3807598: recessive model, P=0.037, OR = 1.29). Both HOTTIP rs2067087 and rs3807598 could affect the expression of mature lncRNA (P=0.003 and P=0.032, respectively). Conclusion: The rs2067087 and rs3807598 SNPs of HOTTIP are associated with gastric cancer risk, possibly by affecting the expression of mature HOTTIP.

Association of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population

2017 ◽  
Vol 26 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Ion Rogoveanu ◽  
Florin Burada ◽  
Mihai Gabriel Cucu ◽  
Cristin Constantin Vere ◽  
Mihai Ioana ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Genetic Model ◽  
Cancer Susceptibility ◽  
Statistical Significance ◽  
Recessive Model ◽  
Nucleotide Polymorphisms ◽  
Gastric Cancer Risk ◽  
Single Nucleotide ◽  
Gastric Cancer Patients

Background & Aims: MicroRNAs (miRNAs) play an important role in the occurrence and progression of human cancers, including gastric cancer. Our hospital-based case-control study aimed to investigate whether four commonly studied single nucleotide polymorphisms (SNPs) have effects on susceptibility to gastric cancer in a Romanian population.Method: We genotyped the miR-27a rs895819, miR-146a rs2910164, miR-196a2 rs11614913 and miR-499 rs3746444 SNPs by real-time PCR using predesignated TaqMan assays in 430 individuals (142 gastric cancer patients and 288 age and gender matched cancer-free controls). The associations between the investigated miRNA SNPs and gastric cancer risk were assessed by odds ratio (OR) with 95% confidence interval (CI) using logistic regression analysis.Results: A higher frequency of the miR-27a rs895819 CC genotype (OR 1.98, 95% CI: 1.05-3.73, p=0.036) was found in the patients with gastric cancer compared with the controls. Similar results were observed in a recessive model, the CC genotype was correlated with gastric cancer susceptibility (OR 1.95, 95% CI: 1.07-3.55, p=0.032). In the stratified analysis, the association between miR-27a rs895819 SNP and gastric cancer risk was limited to noncardia (OR 2.08, 95% CI: 1.10-3.94, p=0.027) and intestinal (OR 2.27, 95% CI: 1.05-4.92, p=0.042) subgroups. However, after Bonferroni correction, all associations described above lost statistical significance. No correlation was observed for the remaining SNPs and risk of gastric cancer in any genetic model studied.Conclusion: This study showed no association of the investigated miRNA SNPs with the risk of gastric cancer in a Romanian population.Key words:  –  –  – .Abbreviations: GC: gastric cancer; miRNA: microRNA; SNP: single nucleotide polymorphism.

scholarly journals A comprehensive evaluation of single nucleotide polymorphisms associated with gastric cancer risk

Medicine ◽  
2020 ◽  
Vol 99 (25) ◽  
pp. e20448
Author(s):  
Zhuo-Miao Ye ◽  
Qing-Yu Hu ◽  
Jing-Hui Zheng ◽  
Chi Zhang ◽  
Xiang-Dong Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Single Nucleotide Polymorphisms ◽  
Comprehensive Evaluation ◽  
Nucleotide Polymorphisms ◽  
Gastric Cancer Risk ◽  
Single Nucleotide
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