scholarly journals Asymptotic Inference for Optimal Rerandomization Designs

2021 ◽  
Vol 1 (1) ◽  
pp. 49-58
Author(s):  
Mårten Schultzberg ◽  
Per Johansson

AbstractRecently a computational-based experimental design strategy called rerandomization has been proposed as an alternative or complement to traditional blocked designs. The idea of rerandomization is to remove, from consideration, those allocations with large imbalances in observed covariates according to a balance criterion, and then randomize within the set of acceptable allocations. Based on the Mahalanobis distance criterion for balancing the covariates, we show that asymptotic inference to the population, from which the units in the sample are randomly drawn, is possible using only the set of best, or ‘optimal’, allocations. Finally, we show that for the optimal and near optimal designs, the quite complex asymptotic sampling distribution derived by Li et al. (2018), is well approximated by a normal distribution.

1998 ◽  
Vol 31 (8) ◽  
pp. 73-78 ◽  
Author(s):  
R. Takors ◽  
D. Weuster-Botz ◽  
W. Wiechert ◽  
C. Wandrey

AIChE Journal ◽  
2005 ◽  
Vol 51 (6) ◽  
pp. 1773-1781 ◽  
Author(s):  
Sébastien Issanchou ◽  
Patrick Cognet ◽  
Michel Cabassud

2012 ◽  
Vol 44 (2) ◽  
pp. 391-407 ◽  
Author(s):  
Anand Bhaskar ◽  
Yun S. Song

Obtaining a closed-form sampling distribution for the coalescent with recombination is a challenging problem. In the case of two loci, a new framework based on an asymptotic series has recently been developed to derive closed-form results when the recombination rate is moderate to large. In this paper, an arbitrary number of loci is considered and combinatorial approaches are employed to find closed-form expressions for the first couple of terms in an asymptotic expansion of the multi-locus sampling distribution. These expressions are universal in the sense that their functional form in terms of the marginal one-locus distributions applies to all finite- and infinite-alleles models of mutation.


Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 7035
Author(s):  
Łukasz Komsta ◽  
Katarzyna Wicha-Komsta ◽  
Tomasz Kocki

This is an introductory tutorial and review about the uncertainty problem in chromatographic calibration. It emphasizes some unobvious, but important details influencing errors in the calibration curve estimation, uncertainty in prediction, as well as the connections and dependences between them, all from various perspectives of uncertainty measurement. Nonuniform D-optimal designs coming from Fedorov theorem are computed and presented. As an example, all possible designs of 24 calibration samples (3–8, 4–6, 6–4, 8–3 and 12–2, both uniform and D-optimal) are compared in context of many optimality criteria. It can be concluded that there are only two independent (orthogonal, but slightly complex) trends in optimality of these designs. The conclusions are important, as the uniform designs with many concentrations are not the best choices, contrary to some intuitive perception. Nonuniform designs are visibly better alternative in most calibration cases.


2012 ◽  
Vol 44 (02) ◽  
pp. 391-407 ◽  
Author(s):  
Anand Bhaskar ◽  
Yun S. Song

Obtaining a closed-form sampling distribution for the coalescent with recombination is a challenging problem. In the case of two loci, a new framework based on an asymptotic series has recently been developed to derive closed-form results when the recombination rate is moderate to large. In this paper, an arbitrary number of loci is considered and combinatorial approaches are employed to find closed-form expressions for the first couple of terms in an asymptotic expansion of the multi-locus sampling distribution. These expressions are universal in the sense that their functional form in terms of the marginal one-locus distributions applies to all finite- and infinite-alleles models of mutation.


SIMULATION ◽  
1992 ◽  
Vol 58 (6) ◽  
pp. 393-394
Author(s):  
Jack P. C. Kleijnen

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