Bor-stabilisierte N,O-Carbene, I Triphenylbor-Addukte von Siloxy-und Hydroxyalkylisocyaniden und spontane At-Ylid-Bildung / Boron-Stabilized N.O-Carbenes, I Triphenylboron Adducts of Siloxy- and Hydroxyalkyl Isocyanides and Spontaneous Formation of Ate-Ylids

1989 ◽  
Vol 44 (4) ◽  
pp. 419-428 ◽  
Author(s):  
Wolf Peter Fehlhammer ◽  
Hans Hoffmeister ◽  
Heribert Stolzenberg ◽  
Borislav Boyadjiev
Keyword(s):  
Intramolecular Cyclization ◽  
Mass Spectra ◽  
H Nmr ◽  
Spontaneous Formation ◽  
Stable Species ◽  
Boron Complexes ◽  
New Compounds

.Triphenylboron adducts of 2- and 3-hydroxyalkyl isocyanides spontaneously undergo intramolecular cyclization to give oxazolidin-2-ylidene and perhydrooxazin-2-ylidene boron complexes, respectively. The same compounds are obtained by methanolysis of the stable species Ph3B-CNCR1R2CR3R4-OSiMe3 (R1, R2, R3, R4 = H, alkyl) (2a-i) and Ph3B-CN(CH2)3-OSiMe3 (2j)IR, 1H NMR, 13C{H} NMR. and mass spectra of the new compounds are reported.

scholarly journals Übergangsmetall-substituierte VB Elementsysteme, 7.

1975 ◽  
Vol 30 (3-4) ◽  
pp. 229-234 ◽  
Author(s):  
Wolfgang Malisch ◽  
Peter Panster
Keyword(s):  
Transition Metal ◽  
Mass Spectroscopy ◽  
Bond Cleavage ◽  
Metal Carbonyl ◽  
Metal Carbonyls ◽  
H Nmr ◽  
Complex Metal ◽  
Stable Species ◽  
New Compounds

The reaction of SbBr3 with the complex metal carbonyl anions [π-C5H6(CO)3M]Na (M = Mo, W) leads to the formation of transition metal antimony bromides π-C5H5(CO)3M-Sb̅-Br2, which can be further metallated, yielding the stable species [XXX]All bromine substituted transition metal stibines prove to be excellent coordinating ligands and can easily be introduced into activated metal carbonyls. The interaction of π-C5H5(CO)3M-Sb̅Br2, with bromine results in a quantitative Sb-M bond cleavage, presumably via primary formation of pentavalent intermediates. All new compounds are fully characterized by means of IR, 1H NMR and mass spectroscopy.

Synthesis of Unsaturated Sulfur-Linked (1→4)-Disaccharides by Substitution of Tosyloxy Group in 1,6-Anhydro-3,4-dideoxy-2-O-tosyl-β-D-erythro-hex-3-enopyranose with 1-Thiohexopyranoses

2000 ◽  
Vol 65 (11) ◽  
pp. 1737-1744 ◽  
Author(s):  
Petr Bartoš ◽  
Miloslav Černý ◽  
Iva Tišlerová ◽  
Tomáš Trnka
Keyword(s):  
Potassium Salt ◽  
Mass Spectra ◽  
H Nmr ◽  
Mild Conditions ◽  
Acid Methanolysis ◽  
Novel Method ◽  
New Compounds

A novel method for the synthesis of unsaturated sulfur-linked (1→4)-disaccharides is described. The starting 1,6-anhydro-3,4-dideoxy-2-O-tosyl-β-D-erythro-hex-3-enopyranose (3) was reacted with potassium salt of acetylated 1-thiohexopyranoses of D-gluco-, D-galacto-, and L-galacto-configuration to give acetylated β-glycopyranosyl-(1→4)-1,6-anhydro-2,3-dideoxy-4-thio-β-D-erythro-hex-2-enopyranoses 8-10. Their acid methanolysis under mild conditions afforded the corresponding methyl glycosides 11-13. The structure of new compounds was confirmed by 1H NMR and mass spectra data.

Siliciumverbindungen mit starken intramolekularen sterischen Wechselwirkungen, VII [1]. Tri-tert-butylsiliciumpseudohalogenide / Silicon Compounds with Strong Intramolecular Steric Interactions, VII [1]. Tri-tert-butylsilicon Pseudohalides

1978 ◽  
Vol 33 (12) ◽  
pp. 1465-1467 ◽  
Author(s):  
Manfred Weidenbruch ◽  
Helge Pesel
Keyword(s):  
Crown Ether ◽  
Mass Spectra ◽  
Steric Interactions ◽  
Silicon Compounds ◽  
H Nmr ◽  
Pseudo Halides ◽  
New Compounds

Abstract Tri-tert-butylchlorosilane reacts with potassium pseudohalides in the presence of catalytic amounts of the crown ether 18-crown-6 to give the tri-tert-butylsilicon pseudo-halides (t-C4H9)3SiX (X = CN, NCO, NCS, N3) in good yields. These new compounds are characterized by IR, 1H NMR, and mass spectra. In the absence of the crown ether no reaction occurs. Treating tri-tert-butylsilane with AgX (X = CN, SCN) gives the silicon pseudohalides in low yields.

Synthesis and Pharmacological Evaluation of a Novel Series of Cyclopentenone Derivatives

2017 ◽  
Vol 41 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Fatma A. El-Samahy ◽  
Marwa El-Hussieny ◽  
Naglaa F. El-Sayed ◽  
Elsayed M. Shalaby ◽  
Fayez H. Osman
Keyword(s):  
Mass Spectra ◽  
Secondary Amines ◽  
X Ray Diffraction ◽  
X Ray ◽  
H Nmr ◽  
Chemical Structures ◽  
Pharmacological Evaluation ◽  
New Compounds ◽  
C Nmr ◽  
Boiling Toluene

A novel series of cyclopent-2-enone derivatives have been synthesised by the reaction of 4-hydroxy-3,4-diphenylcyclopent-2-enone, cyclic secondary amines, phosphorus reagents, hexamethylphosphoramide and Lawesson's reagent in boiling toluene/THF. The chemical structures of new compounds were identified by 1H NMR, 13C NMR, 31P NMR and mass spectra. Furthermore, the structure of one of the synthesised compounds has been confirmed using single crystal X-ray diffraction. The pharmacological evaluation results of antilung and anticolon carcinoma cell line properties for the products are discussed.

Siliciumverbindungen mit starken intramolekularen sterischen Wechselwirkungen, VIII [1]. Neue Siloxanverbindungen einiger Übergangsmetalle / Silicon Compounds with Strong Intramolecular Steric Interactions, VIII [1]. New Siloxane Compounds of Some Transition Metals

1978 ◽  
Vol 33 (12) ◽  
pp. 1468-1471 ◽  
Author(s):  
Manfred Weidenbruch ◽  
Claude Pierrard ◽  
Helge Pesel
Keyword(s):  
Thermal Stability ◽  
Transition Metals ◽  
Mass Spectra ◽  
The Other ◽  
Similar Reaction ◽  
Silicon Compounds ◽  
Good Thermal Stability ◽  
H Nmr ◽  
Binary Oxides ◽  
New Compounds

Abstract Tri-tert-butylsiloxane compounds of transition metals are obtained by two different routes, one of these involves condensation of tri-tert-butylsilanol with the binary oxides V2O5, CrO3, MoO3, and Re2O7, while the other proceeds via a similar reaction between the chlorides VOCl3, NbCl5, TaCl5, CrO2Cl2, and the silanol. The new compounds, having good thermal stability and remarkable resistence to hydrolysis, are characterized by IR, 1H NMR, and mass spectra.

Chemie der Isoblausäure, II Reaktionen von [M(CO)5CNH] (M = Cr, Mo, W) mit Aziridinen: Zyklische Diaminocarbenkomplexe / Chemistry of Hydrogen Isocyanide, II Reactions of [M(CO)5CNH] (M = Cr, Mo, W) with Aziridines: Cyclic Diaminocarbene Complexes

1986 ◽  
Vol 41 (8) ◽  
pp. 1023-1027 ◽  
Author(s):  
Wolf Peter Fehlhammer ◽  
Eberhard Bär ◽  
Borislav Boyadjiev
Keyword(s):  
Mass Spectra ◽  
H Nmr ◽  
Hydrogen Isocyanide ◽  
New Compounds ◽  
C Nmr

Abstract The hydrogen isocyanide complexes [M (CO)5CNH] (M = Cr, Mo, W) have been treated with the aziridines R [xxx] H2 (R = H, R’ = H, Me, Et; R = Me, R’ = H) to give imidazolidin-2-ylidene complexes. The same type of ligand forms on addition of aziridine to the electrophilic isocyanide group in [FpCNPh]+ in the presence of Br−, IR, 1H NMR, 13C NMR and mass spectra of the new compounds are reported.

Utility of Cyano Acid Hydrazide in Heterocyclic Chemistry: A New Route for the Synthesis of New 1,2,4-Triazolo[1,5-a]pyridines and 1,2,4-Triazolo[1,5-a]isoquinolines

1998 ◽  
Vol 53 (4) ◽  
pp. 488-494 ◽  
Author(s):  
Abdel Haleem Mostafa Hussein
Keyword(s):  
Mass Spectra ◽  
Elemental Sulfur ◽  
Acid Hydrazide ◽  
Aromatic Aldehydes ◽  
Heterocyclic Chemistry ◽  
Aliphatic Aldehydes ◽  
H Nmr ◽  
New Compounds ◽  
Active Methylene

Cyano acid hydrazide 1 was condensed with cyclohexanone in refluxing ethanolic piperidine to yield the hydrazone 4. Compound 4 reacts with arylidines 5a-i to yield the 1,2.4- triazolo[1,5-a]pyridines 7a-i. Compound 4 also reacts with mixtures of aliphatic aldehydes and different active methylene reagents to yield 1,2,4-triazolo[1,5-a]pyridines 8a-d. Similarly reaction of 4 with arylazomalononitrile to yield the triazolopyridines 10a-d Reaction of 4 with aromatic aldehydes gives 12a-e. Compound 8a reacts with elemental sulfur to yield the thieno-1,2,4-triazolopyridine 13. This underwent cycloaddition with acrylonitrile, ω-nitrostyrene, chalcone, N-phenylmalemide, dimethylacetylenedicarboxylate and tetracyanoethylene yielding the isoquinolines 15-18. All new compounds have been characterized by their IR. 1H NMR and mass spectra.

scholarly journals Novel Aryl Ether Derivatives as Antiinflammatory and Analgesics

2011 ◽  
Vol 8 (3) ◽  
pp. 1401-1407
Author(s):  
P. Rashmi ◽  
Gopal Krishna Rao ◽  
Kshama Devi ◽  
B. G. Shivananda ◽  
G. R. Swetha ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Mass Spectra ◽  
Biological Activities ◽  
Aryl Ether ◽  
H Nmr ◽  
Diaryl Ether ◽  
Wide Range ◽  
Aryl Ethers ◽  
New Compounds

The diaryl ether moieties have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities. The present study involves synthesis, characterization of some new aryl ethers and evaluation of their antiinflammatory and analgesic activity. A series of new aryl ether derivatives[4(a-h), 5]were prepared by Ullmann’s ether condensation. The structures of new compounds are supported by their IR,1H NMR and Mass spectra. The new derivatives were evaluated for their antiinflammatory and analgesic activity. Among the tested, compound3has shown better antiinflammatory and analgesic activity.

Synthesis of 2-amino-5,7-dimethyl-4-oxopyrido[3,4-e]-1,3-thiazines

1983 ◽  
Vol 48 (12) ◽  
pp. 3426-3432 ◽  
Author(s):  
Dušan Koščík ◽  
Pavol Kristian ◽  
Ondrej Forgáč
Keyword(s):  
Spectral Data ◽  
Chlorine Atom ◽  
Mass Spectra ◽  
High Reactivity ◽  
Secondary Amines ◽  
Dimroth Rearrangement ◽  
H Nmr ◽  
New Synthesis ◽  
C Nmr

New synthesis of pyrido[3,4-e]-1,3-thiazines consisting in reaction of 2,6-dimethyl-4-chloronicotinoyl isothiocyanate with primary or secondary amines, or with benzaldehyde phenylhydrazone, is described. High reactivity of the chlorine atom does not allow isolation of the corresponding thioureas, arising as intermediates, except in the case of the benzylamino derivative. Structure of the products was unequivocally confirmed by their spectral data (IR, UV, 1H NMR, 13C NMR and mass spectra). The synthesized derivatives do not undergo the Dimroth rearrangement.

Cyclopropyl→cyclobutyl rearrangement in intramolecular cyclization of 3,5-bridged B-secoandrostane-6,7(or 5,7)-diols and mass spectra of products

1982 ◽  
Vol 47 (8) ◽  
pp. 2280-2290 ◽  
Author(s):  
Helena Velgová ◽  
Jorga Smolíková ◽  
Antonín Trka ◽  
Antonín Vítek
Keyword(s):  
Intramolecular Cyclization ◽  
Mass Spectra ◽  
Acid Catalyzed

Acid-catalyzed intramolecular cyclization of 6,7-dihydroxy-3α,5-cyclo-6,7-seco-5α-androstan-17-one (VII), 5,7-dihydroxy-3,5-methylene-5,7-secoandrostan-17-one and 5,7-dihydroxy-3β,5-cyclo-5,7-seco-A-homo-5β-androstan-17-one (XIII) in benzene and dioxane was investigated. The main cyclization products were 3,5-methylene-6-oxaandrostan-17-one (I) and/or 3β,5-cyclo-6-oxa-A-homo-5β-androstan-17-one (VIII). In the case of VI and VII the ratio of I and VIII was solvent-dependent: in benzene more VIII was formed than in dioxane. The mass spectra of I and VIII were almost identical and corresponded to the structure VIII.

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