scholarly journals Intrauterine growth restriction causes abnormal embryonic dentate gyrus neurogenesis in mouse offspring that leads to adult learning and memory deficits

eNeuro ◽  
2021 ◽  
pp. ENEURO.0062-21.2021
Author(s):  
Ashley S. Brown ◽  
Matthew Wieben ◽  
Shelby Murdock ◽  
Jill Chang ◽  
Maria Dizon ◽  
...  
Keyword(s):  
Adult Learning ◽  
Dentate Gyrus ◽  
Learning And Memory ◽  
Intrauterine Growth Restriction ◽  
Memory Deficits ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Learning And Memory Deficits

scholarly journals Intrauterine growth restriction causes cellular, molecular, and behavioral deficits consistent with abnormal dentate gyrus neurogenesis in mice

2020 ◽  
Author(s):  
Ashley S. Brown ◽  
Matthew Wieben ◽  
Shelby Murdock ◽  
Jill Chang ◽  
Maria Dizon ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Learning And Memory ◽  
Intrauterine Growth Restriction ◽  
Memory Function ◽  
Memory Deficits ◽  
Growth Restriction ◽  
Environmental Signals ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Learning And Memory Deficits

AbstractBackgroundChildren born with intrauterine growth restriction (IUGR) are at increased risk for cognitive impairment including learning and memory deficits. Dentate gyrus (DG) granule neurons relay cortical information into the hippocampus proper for memory formation, and their production is highly dependent on environmental signals. However, it is unknown whether IUGR affects DG neurogenesis, and thus provides a potential mechanism underlying abnormal learning and memory function.MethodsUsing a hypertensive disease of pregnancy mouse model of IUGR, we assessed multiple behaviors, quantified neural stem and progenitor cells (NSPCs) and developing neurons in the DG, and characterized transcriptional effects on molecular pathways in the hippocampus.ResultsWe found that the predominant behavioral phenotype in IUGR offspring, short-term implicit learning and memory deficits, was associated with accelerated DG neurogenesis and NSPC depletion. Consistent with known molecular regulators of DG neurogenesis, we also found strong evidence for decreased Wnt pathway activity following IUGR.ConclusionWe have discovered that postnatal memory deficits are associated with accelerated NSPC differentiation following IUGR, a phenotype that could be explained by decreased Wnt signaling.

scholarly journals Influence of catch up growth on spatial learning and memory in a mouse model of intrauterine growth restriction

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177468 ◽  
Author(s):  
Cristina Duran Fernandez-Feijoo ◽  
Cristina Carrasco Carrasco ◽  
Núria Villalmazo Francisco ◽  
Judit Cebrià Romero ◽  
Jose Ramon Fernández Lorenzo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Spatial Learning And Memory ◽  
Intrauterine Growth ◽  
Catch Up

Apoptosis of mouse hippocampal cells induced by Taenia crassiceps metacestode factor

2016 ◽  
Vol 91 (2) ◽  
pp. 215-221 ◽  
Author(s):  
N. Zepeda ◽  
S. Solano ◽  
N. Copitin ◽  
J.L. Chávez ◽  
A.M. Fernández ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Learning And Memory ◽  
Signs And Symptoms ◽  
Memory Deficits ◽  
Neurological Deficits ◽  
Intact Cells ◽  
Taenia Crassiceps ◽  
Experimental Animals ◽  
Learning And Memory Deficits

AbstractSeizures, headache, depression and neurological deficits are the signs and symptoms most frequently reported in human neurocysticercosis. However, the cause of the associated learning and memory deficits is unknown. Here, we used Taenia crassiceps infection in mice as a model of human cysticercosis. The effects of T. crassiceps metacestode infection or T. crassiceps metacestode factor (MF) treatment on mouse hippocampal cells were studied; control mice were included. At 45 days after infection or treatment of the mice with MF, all mice were anaesthetized and perfused transcardially with saline followed by phosphate-buffered 10% formalin. Then the brains were carefully removed. Coronal sections stained using several techniques were analysed. Extensive and significant apoptosis was found in the experimental animals, mainly in the dentate gyrus, CA1, CA2, CA3 and neighbouring regions, in comparison with the apparently intact cells from control mice (P < 0.01). These results suggest that neurological deficits, especially the learning and memory deficits, may be generated by extensive apoptosis of hippocampal cells.

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

Sign in / Sign up

Export Citation Format

Share Document