scholarly journals The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 ◽  
Vol 7 (7) ◽  
pp. 2203-2213 ◽  
Author(s):  
V Gallo ◽  
A Kingsbury ◽  
R Balazs ◽  
OS Jorgensen
2003 ◽  
Vol 18 (8) ◽  
pp. 2265-2272 ◽  
Author(s):  
Sonia Mulero-Navarro ◽  
Belen Santiago-Josefat ◽  
Eulalia Pozo-Guisado ◽  
Jaime M. Merino ◽  
Pedro M. Fernandez-Salguero

1988 ◽  
Vol 448 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Ann Kingsbury ◽  
Vittorio Gallo ◽  
Robert Balazs

Development ◽  
1999 ◽  
Vol 126 (16) ◽  
pp. 3585-3596 ◽  
Author(s):  
D. Engelkamp ◽  
P. Rashbass ◽  
A. Seawright ◽  
V. van Heyningen

Post-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6, a key regulator in CNS and eye development, is strongly expressed in rhombic lip and in cells migrating away from it. Development of some structures derived from these cells is severely affected in Pax6-null Small eye (Pax6(Sey)/Pax6(Sey)) embryos. Cell proliferation and initial differentiation seem unaffected, but cell migration and neurite extension are disrupted in mutant embryos. Three of the five precerebellar nuclei fail to form correctly. In the cerebellum the pre-migratory granule cell sub-layer and fissures are absent. Some granule cells are found in ectopic positions in the inferior colliculus which may result from the complete absence of Unc5h3 expression in Pax6(Sey)/Pax6(Sey) granule cells. Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3.


2015 ◽  
Vol 28 (3) ◽  
pp. 195-208 ◽  
Author(s):  
Elzbieta Zieminska ◽  
Aleksandra Stafiej ◽  
Beata Toczylowska ◽  
Jan Albrecht ◽  
Jerzy W. Lazarewicz

2001 ◽  
Vol 39 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Barbara Monti ◽  
Paolo Zanghellini ◽  
Antonio Contestabile

2009 ◽  
Vol 29 (9) ◽  
pp. 2938-2947 ◽  
Author(s):  
M. Okazawa ◽  
H. Abe ◽  
M. Katsukawa ◽  
K. Iijima ◽  
T. Kiwada ◽  
...  

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