scholarly journals The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice

2019 ◽  
Vol 39 (32) ◽  
pp. 6325-6338 ◽  
Author(s):  
Rick E. Bernardi ◽  
Anastasia Olevska ◽  
Ilaria Morella ◽  
Stefania Fasano ◽  
Eugenio Santos ◽  
...  
Keyword(s):  
2021 ◽  
pp. 108753
Author(s):  
Pablo Giménez-Gómez ◽  
Raúl Ballestín ◽  
Leticia Gil de Biedma-Elduayen ◽  
Rebeca Vidal ◽  
Carmen Ferrer-Pérez ◽  
...  

2013 ◽  
Vol 38 (9) ◽  
pp. 1763-1769 ◽  
Author(s):  
Bin Wang ◽  
Zhi-Bing You ◽  
Erik B Oleson ◽  
Joseph F Cheer ◽  
Stephanie Myal ◽  
...  

2009 ◽  
Vol 29 (11) ◽  
pp. 3529-3537 ◽  
Author(s):  
S. J. Russo ◽  
M. B. Wilkinson ◽  
M. S. Mazei-Robison ◽  
D. M. Dietz ◽  
I. Maze ◽  
...  

Cell Reports ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 319-332 ◽  
Author(s):  
Hong-Ju Yang ◽  
Hai-Ying Zhang ◽  
Guo-Hua Bi ◽  
Yi He ◽  
Jun-Tao Gao ◽  
...  

Author(s):  
Aiko Ikegami ◽  
Christine L. Duvauchelle
Keyword(s):  

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1462
Author(s):  
Dawid Gawliński ◽  
Kinga Gawlińska ◽  
Małgorzata Frankowska ◽  
Małgorzata Filip

Recent studies have emphasized the role of the maternal diet in the development of mental disorders in offspring. Substance use disorder is a major global health and economic burden. Therefore, the search for predisposing factors for the development of this disease can contribute to reducing the health and social damage associated with addiction. In this study, we focused on the impact of the maternal diet on changes in melanocortin-4 (MC-4) receptors as well as on behavioral changes related to cocaine addiction. Rat dams consumed a high-fat diet (HFD), high-sugar diet (HSD, rich in sucrose), or mixed diet (MD) during pregnancy and lactation. Using an intravenous cocaine self-administration model, the susceptibility of female offspring to cocaine reward and cocaine-seeking propensities was evaluated. In addition, the level of MC-4 receptors in the rat brain structures related to cocaine reward and relapse was assessed. Modified maternal diets did not affect cocaine self-administration in offspring. However, the maternal HSD enhanced cocaine-seeking behavior in female offspring. In addition, we observed that the maternal HSD and MD led to increased expression of MC-4 receptors in the nucleus accumbens, while increased MC-4 receptor levels in the dorsal striatum were observed after exposure to the maternal HSD and HFD. Taken together, it can be concluded that a maternal HSD is an important factor that triggers cocaine-seeking behavior in female offspring and the expression of MC-4 receptors.


2017 ◽  
Vol 171 ◽  
pp. e4
Author(s):  
Ugochukwu Akpara ◽  
Rina Liang ◽  
Avery Villa-Gonzalez ◽  
Denzel Harrris ◽  
Adel Elzanie ◽  
...  

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