scholarly journals A Conditioned Place Preference for Heroin Is Signaled by Increased Dopamine and Direct Pathway Activity and Decreased Indirect Pathway Activity in the Nucleus Accumbens

2022 ◽  
pp. JN-RM-1451-21
Author(s):  
Timothy J. O’Neal ◽  
Mollie X. Bernstein ◽  
Derek J. MacDougall ◽  
Susan M. Ferguson
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Indirect Pathway ◽  
Pathway Activity ◽  
Direct Pathway

scholarly journals A conditioned place preference for heroin is signaled by increased dopamine and direct pathway activity and decreased indirect pathway activity in the nucleus accumbens

2021 ◽  
Author(s):  
Timothy J O'Neal ◽  
Mollie X Bernstein ◽  
Derek J MacDougall ◽  
Susan M Ferguson
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Indirect Pathway ◽  
Pathway Activity ◽  
Principal Role ◽  
Direct Pathway ◽  
Dopamine Signaling

Initial drug use promotes the development of conditioned reinforcement, whereby the reinforcing properties of a drug become attributed to drug-associated stimuli, such as cues and contexts. A principal role for the nucleus accumbens (NAc) in the response to drug-associated stimuli has been well-documented. In particular, direct and indirect pathway medium spiny neurons (dMSNs and iMSNs) have been shown to bidirectionally regulate cue-induced heroin-seeking in rats expressing addiction-like phenotypes, and a shift in NAc activity towards the direct pathway has been shown in mice following cocaine conditioned place preference (CPP). However, how NAc signaling guides heroin CPP, and whether heroin alters the balance of signaling between dMSNs and iMSNs remains unknown. Moreover, the role of NAc dopamine signaling in heroin reinforcement remains unclear. Here, we integrate fiber photometry for in vivo monitoring of dopamine and dMSN/iMSN calcium activity with a heroin CPP procedure in rats to address these outstanding questions. We identify a sensitization-like response to heroin in the NAc, with prominent iMSN activity during initial heroin exposure and prominent dMSN activity following repeated heroin exposure. We demonstrate a ramp in dopamine activity, dMSN activation, and iMSN inactivation preceding entry into a heroin-paired context, and a decrease in dopamine activity, dMSN inactivation, and iMSN activation preceding exit from a heroin-paired context. Finally, we show that buprenorphine is sufficient to prevent the development of heroin CPP and activation of the NAc post-conditioning. Together, these data support the hypothesis that an imbalance in NAc activity contributes to the development of addiction.

Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens

2010 ◽  
Vol 58 (1) ◽  
pp. 233-240 ◽  
Author(s):  
Jing Liang ◽  
Xing-Jie Ping ◽  
Yi-Jing Li ◽  
Yao-Ying Ma ◽  
Liu-Zhen Wu ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference

Intra-nucleus-accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats

PsyCh Journal ◽  
2012 ◽  
Vol 1 (1) ◽  
pp. 2-14 ◽  
Author(s):  
Jun Gao ◽  
Ning Zhu ◽  
Min Feng ◽  
Xiaolu Meng ◽  
Nan Sui
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference

scholarly journals Nucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference

2009 ◽  
Vol 34 (8) ◽  
pp. 1993-2001 ◽  
Author(s):  
Darlene H Brunzell ◽  
Yann S Mineur ◽  
Rachael L Neve ◽  
Marina R Picciotto
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference
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