scholarly journals Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient

1996 ◽  
Vol 16 (3) ◽  
pp. 1140-1149 ◽  
Author(s):  
JQ Zheng ◽  
JJ Wan ◽  
MM Poo
Keyword(s):  
Growth Cone ◽  
Essential Role ◽  
Nerve Growth ◽  
Nerve Growth Cone

scholarly journals Radixin Is Involved in Lamellipodial Stability during Nerve Growth Cone Motility

1999 ◽  
Vol 10 (5) ◽  
pp. 1511-1520 ◽  
Author(s):  
Leslie Castelo ◽  
Daniel G. Jay
Keyword(s):  
Growth Cone ◽  
Critical Role ◽  
Leading Edge ◽  
Growth Cones ◽  
Forward Movement ◽  
Nerve Growth ◽  
Nerve Growth Cone

Immunocytochemistry and in vitro studies have suggested that the ERM (ezrin-radixin-moesin) protein, radixin, may have a role in nerve growth cone motility. We tested the in situ role of radixin in chick dorsal root ganglion growth cones by observing the effects of its localized and acute inactivation. Microscale chromophore-assisted laser inactivation (micro-CALI) of radixin in growth cones causes a 30% reduction of lamellipodial area within the irradiated region whereas all control treatments did not affect lamellipodia. Micro-CALI of radixin targeted to the middle of the leading edge often split growth cones to form two smaller growth cones during continued forward movement (>80%). These findings suggest a critical role for radixin in growth cone lamellipodia that is similar to ezrin function in pseudopodia of transformed fibroblasts. They are consistent with radixin linking actin filaments to each other or to the membrane during motility.

scholarly journals Plasmalemmal insertion and modification of sodium channels at the nerve growth cone

1992 ◽  
Vol 12 (8) ◽  
pp. 2948-2959 ◽  
Author(s):  
MR Wood ◽  
J DeBin ◽  
GR Strichartz ◽  
KH Pfenninger
Keyword(s):  
Sodium Channels ◽  
Growth Cone ◽  
Nerve Growth ◽  
Nerve Growth Cone

scholarly journals c-src gene product in developing rat brain is enriched in nerve growth cone membranes.

1988 ◽  
Vol 85 (14) ◽  
pp. 5001-5005 ◽  
Author(s):  
P. F. Maness ◽  
M. Aubry ◽  
C. G. Shores ◽  
L. Frame ◽  
K. H. Pfenninger
Keyword(s):  
Rat Brain ◽  
Gene Product ◽  
Growth Cone ◽  
Nerve Growth ◽  
Src Gene ◽  
Nerve Growth Cone ◽  
Developing Rat

Characterization of Phospholipase A2 Activity Enriched in the Nerve Growth Cone

2002 ◽  
Vol 67 (6) ◽  
pp. 2599-2608 ◽  
Author(s):  
Pascale Nègre-Aminou ◽  
Raphael A. Nemenoff ◽  
Malcolm R. Wood ◽  
B. A. De La Houssaye ◽  
K. H. Pfenninger
Keyword(s):  
Phospholipase A2 ◽  
Growth Cone ◽  
Nerve Growth ◽  
Nerve Growth Cone ◽  
Phospholipase A2 Activity

scholarly journals Membrane Tension, Myosin Force, and Actin Turnover Maintain Actin Treadmill in the Nerve Growth Cone

2012 ◽  
Vol 102 (7) ◽  
pp. 1503-1513 ◽  
Author(s):  
Erin M. Craig ◽  
David Van Goor ◽  
Paul Forscher ◽  
Alex Mogilner
Keyword(s):  
Growth Cone ◽  
Membrane Tension ◽  
Nerve Growth ◽  
Actin Turnover ◽  
Nerve Growth Cone
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