scholarly journals Role of Bed Nucleus of the Stria Terminalis Corticotrophin-Releasing Factor Receptors in Frustration Stress-Induced Binge-Like Palatable Food Consumption in Female Rats with a History of Food Restriction

2014 ◽  
Vol 34 (34) ◽  
pp. 11316-11324 ◽  
Author(s):  
M. V. Micioni Di Bonaventura ◽  
R. Ciccocioppo ◽  
A. Romano ◽  
J. M. Bossert ◽  
K. C. Rice ◽  
...  
Keyword(s):  
Food Consumption ◽  
Food Restriction ◽  
Female Rats ◽  
Stria Terminalis ◽  
Palatable Food ◽  
Bed Nucleus ◽  
Corticotrophin Releasing Factor ◽  
History Of

The role of the anteriolateral bed nucleus of the stria terminalis in stress-induced nociception

2012 ◽  
Vol 302 (11) ◽  
pp. G1301-G1309 ◽  
Author(s):  
Lee Tran ◽  
Brandt Wiskur ◽  
Beverley Greenwood-Van Meerveld
Keyword(s):  
Stria Terminalis ◽  
Mrna Levels ◽  
Bed Nucleus ◽  
Corticotrophin Releasing Factor ◽  
Visceromotor Response ◽  
Dependent Mechanism ◽  
Von Frey Filaments ◽  
Stimulation Of

Activation of the central amygdala (CeA) by corticosterone (CORT) induces somatic and colonic hypersensitivity through corticotrophin-releasing factor (CRF)-dependent mechanisms. However, the importance of the bed nucleus of the stria terminalis (BNST), part of the extended amygdala, on nociception remains unexplored. In the present study, we test the hypothesis that stimulation of the CeA by CORT induces somatic and colonic hypersensitivity through activation of the anteriolateral BNST (BNSTAL). Animals were implanted with micropellets of CORT or cholesterol (CHOL) onto the CeA or the BNSTAL. Mechanical sensitivity was quantified using electronic von Frey filaments, and colonic nociception was measured by quantifying a visceromotor response to graded colorectal distension. In situ hybridization was used to determine mRNA levels for CRF, CRF1, and CRF2 receptors in the BNSTAL. In a second group, animals were implanted bilaterally with 1) CORT or CHOL micropellets onto the CeA; and 2) cannulas localized to the BNSTAL to administer a CRF1 receptor antagonist (CP376395). Animals implanted with CORT onto the CeA, but not the BNSTAL, exhibited increased expression of CRF mRNA and increased CRF1-to-CRF2 receptor ratio in the BNST, as well as somatic and colonic hypersensitivity compared with CHOL controls. Infusion of CP376395 into the BNSTAL inhibited somatic and colonic hypersensitivity in response to elevated amygdala CORT. Somatic and colonic hypersensitivity induced by elevated amygdala CORT is mediated via a CRF1 receptor-dependent mechanism in the BNSTAL. The CeA through a descending pathway involving the BNSTAL plays a pivotal role in somatic and colonic nociception.

scholarly journals Amygdala-lesion obesity: what is the role of the various amygdaloid nuclei?

2000 ◽  
Vol 279 (4) ◽  
pp. R1348-R1356 ◽  
Author(s):  
Bethany L. Rollins ◽  
Bruce M. King
Keyword(s):  
Female Rats ◽  
Amygdaloid Nucleus ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Common Area ◽  
Weight Gains ◽  
Bilateral Lesions ◽  
Medial Amygdaloid Nucleus ◽  
Amygdaloid Nuclei

Anatomic descriptions of amygdaloid lesions resulting in hyperphagia and obesity in rats, cats, and dogs have been inconsistent and often contradictory, frequently resulting in failures to replicate. The present study attempted to reconcile these differences by examining common areas of overlap among differently placed lesions in female rats. Small bilateral lesions of the most posterodorsal aspects of the amygdala resulted in substantial weight gains (mean = 45.4 g/10 days). The smallest lesions caused damage limited to the posterodorsal medial amygdaloid nucleus and the bed nucleus of the stria terminalis and were directly in the area where axons are collecting to form the stria terminalis. Larger lesions that extensively damaged the central and/or anterodorsal medial amygdaloid nuclei sometimes resulted in excess weight gains, as did very large lesions of the basolateral nuclei, but substantial weight gains occurred only when the lesions extended (unilaterally or bilaterally) into the posterodorsal amygdala. Examination of previously published brain sections indicated that the hyperphagia and obesity that have been observed after widely differing lesion placements in cats and dogs were also the result of damage to a common area of overlap (i.e., the bed nucleus and/or stria terminalis). In rats, the critical area producing weight gain has extensive reciprocal relations with the medial hypothalamus.

Mo1100 Stress-Induced Colonic Hypersensitivity: the Role of the Bed Nucleus of the Stria Terminalis

2012 ◽  
Vol 142 (5) ◽  
pp. S-595
Author(s):  
Lee Tran ◽  
Beverley Greenwood-Van Meerveld
Keyword(s):  
Stria Terminalis ◽  
Bed Nucleus

scholarly journals Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear

2019 ◽  
Author(s):  
Travis D. Goode ◽  
Gillian M. Acca ◽  
Stephen Maren
Keyword(s):  
Unconditioned Stimulus ◽  
Fear Conditioning ◽  
Stria Terminalis ◽  
Conditioning Procedure ◽  
Conditioned Stimuli ◽  
Reversible Inactivation ◽  
Bed Nucleus ◽  
Contextual Fear ◽  
Context Dependent

ABSTRACTPrevious work indicates that the bed nucleus of the stria terminalis (BNST) is involved in defensive freezing to unpredictable Pavlovian conditioned stimuli (Goode et al., 2019). Here we show that the BNST mediates freezing to contexts paired with remote (unpredictable), but not imminent (predictable), footshock. Rats underwent a fear conditioning procedure in which a single footshock unconditioned stimulus (US) was delivered either 1 (imminent) or 9 minutes (remote) after placement in the context; each rat received a total of four conditioning trials over two days. Contexts associated with either imminent or remote USs produced distinct patterns of freezing and shock-induced activity but freezing in each case was context-dependent. Reversible inactivation of the BNST reduced the expression of contextual freezing in the context paired with remote, but not imminent, footshock. Implications of these data are discussed in light of recent conceptualizations of BNST function, as well as for anxiety behaviors.

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