scholarly journals Pro-Brain-Derived Neurotrophic Factor Inhibits GABAergic Neurotransmission by Activating Endocytosis and Repression of GABAA Receptors

2014 ◽  
Vol 34 (40) ◽  
pp. 13516-13534 ◽  
Author(s):  
B. Riffault ◽  
I. Medina ◽  
C. Dumon ◽  
C. Thalman ◽  
N. Ferrand ◽  
...  
Keyword(s):  
Gabaa Receptors ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Gabaergic Neurotransmission

scholarly journals Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture

2019 ◽  
Vol 20 (2) ◽  
pp. 285 ◽  
Author(s):  
Jennifer Rakotomamonjy ◽  
Abdel Ghoumari
Keyword(s):  
Gabaa Receptors ◽  
Neurotrophic Factor ◽  
Neuroprotective Effect ◽  
Brain Derived Neurotrophic Factor ◽  
Aminobutyric Acid ◽  
Purkinje Neurons ◽  
Slice Culture ◽  
Dependent Activity ◽  
Purkinje Cell Death ◽  
Cerebellar Cultures

Endogenous γ-aminobutyric acid (GABA)-dependent activity induces death of developing Purkinje neurons in mouse organotypic cerebellar cultures and the synthetic steroid mifepristone blocks this effect. Here, using brain-derived neurotrophic factor (BDNF) heterozygous mice, we show that BDNF plays no role in immature Purkinje cell death. However, interestingly, BDNF haploinsufficiency impairs neuronal survival induced by mifepristone and GABAA-receptors antagonist (bicuculline) treatments, indicating that the underlying neuroprotective mechanism requires the neurotrophin full expression.

Brain Derived Neurotrophic Factor Gene Polymorphism Associated With Language Acquisition

2007 ◽  
Author(s):  
Scott H. Fraundorf ◽  
Brad E. Sheese ◽  
Lauren K. White ◽  
Mary K. Rothbart ◽  
Michael I. Posner
Keyword(s):  
Language Acquisition ◽  
Gene Polymorphism ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene
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