scholarly journals Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease

2002 ◽  
Vol 22 (11) ◽  
pp. 4639-4653 ◽  
Author(s):  
Joshua A. Goldberg ◽  
Thomas Boraud ◽  
Sharon Maraton ◽  
Suzanne N. Haber ◽  
Eilon Vaadia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Primate Model

Lack of LTP-like plasticity in primary motor cortex in Parkinson's disease

2011 ◽  
Vol 227 (2) ◽  
pp. 296-301 ◽  
Author(s):  
A. Suppa ◽  
L. Marsili ◽  
D. Belvisi ◽  
A. Conte ◽  
E. Iezzi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex

scholarly journals Acute dopamine boost has a negative effect on plasticity of the primary motor cortex in advanced Parkinson's disease

Brain ◽  
2012 ◽  
Vol 135 (7) ◽  
pp. 2074-2088 ◽  
Author(s):  
A. Kishore ◽  
T. Popa ◽  
B. Velayudhan ◽  
T. Joseph ◽  
A. Balachandran ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Advanced Parkinson’S Disease ◽  
Negative Effect

Long-term effect of safinamide on primary motor cortex excitability and plasticity in Parkinson's disease: A TMS study

2021 ◽  
Vol 429 ◽  
pp. 119453
Author(s):  
Valentina D'Onofrio ◽  
Andrea Guerra ◽  
Francesco Asci ◽  
Giovanni Fabbrini ◽  
Alfredo Berardelli ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Term Effect ◽  
Long Term Effect ◽  
Motor Cortex Excitability

scholarly journals Enhancing Gamma Oscillations Restores Primary Motor Cortex Plasticity in Parkinson's Disease

2020 ◽  
Vol 40 (24) ◽  
pp. 4788-4796 ◽  
Author(s):  
Andrea Guerra ◽  
Francesco Asci ◽  
Valentina D'Onofrio ◽  
Valerio Sveva ◽  
Matteo Bologna ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Gamma Oscillations ◽  
Motor Cortex Plasticity

scholarly journals Pain-motor integration in the primary motor cortex in Parkinson's disease

2017 ◽  
Vol 10 (4) ◽  
pp. 806-816 ◽  
Author(s):  
A. Suppa ◽  
C. Leone ◽  
F. Di Stasio ◽  
L. Marsili ◽  
A. Di Santo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex

1Hz rTMS Preconditioned by tDCS Over the Primary Motor Cortex in Parkinson’s Disease: Absence of Effect on Arm Lift and Hand Grip Force Control

Motor Control ◽  
2012 ◽  
Vol 16 (2) ◽  
pp. 284-292 ◽  
Author(s):  
Carsten Eggers ◽  
Ulrike Grüner ◽  
Mitra Ameli ◽  
Anna-Sophia Sarfeld ◽  
Dennis A. Nowak
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Force Control ◽  
Grip Force ◽  
Primary Motor Cortex ◽  
Grip Force Control ◽  
Hand Grip

scholarly journals Pallidal Thermolesion Unleashes Gamma Oscillations in the Motor Cortex in Parkinson's Disease

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Doris D Wang ◽  
Coralie de Hemptinne ◽  
Svjetlana Miocinovic ◽  
Witney Chen ◽  
Jill L Ostrem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Essential Tremor ◽  
Primary Motor Cortex ◽  
Gamma Oscillations ◽  
Gamma Band ◽  
Motor Dysfunction ◽  
Oscillatory Activity ◽  
Motor Network

Abstract INTRODUCTION In Parkinson's disease, the emergence of motor dysfunction is thought to be related to an imbalance between antikinetic and prokinetic patterns of oscillatory activity in the motor network. Invasive recordings from the basal ganglia and cortex in surgical patients have suggested that levodopa and therapeutic deep brain stimulation can suppress antikinetic beta band (13-30 Hz) rhythms while promoting prokinetic gamma band (60-90 Hz) rhythms. Surgical ablation of the globus pallidus internus is one of the oldest effective therapies for Parkinson's disease and gives a remarkable immediate relief from rigidity and bradykinesia, but its effects on oscillatory activity in the motor network have not been studied. We characterize the effects of pallidotomy on cortical oscillatory activity in Parkinson's disease patients. METHODS Using a temporary 6-contact lead placed over the sensorimotor cortex in the subdural space, we recorded acute changes in cortical oscillatory activities in 3 Parkinson's disease patients undergoing pallidotomy and compared the results to that of 3 essential tremor patients undergoing thalamotomy. RESULTS In all 3 Parkinson's disease patients, we observed the emergence of an approximately 70 to 80 Hz narrow-band oscillation with effective thermolesion of the pallidum. This gamma oscillatory activity was spatially localized over the primary motor cortex, was minimally affected by voluntary movements, and was not found in the motor cortex of essential tremor patients undergoing thalamotomy. CONCLUSION Our finding suggests that acute lesioning of the pallidum promotes cortical gamma band oscillations. This may represent an important mechanism for alleviating bradykinesia in Parkinson's disease.

scholarly journals Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease

2018 ◽  
Vol 38 (19) ◽  
pp. 4556-4568 ◽  
Author(s):  
Doris D. Wang ◽  
Coralie de Hemptinne ◽  
Svjetlana Miocinovic ◽  
Jill L. Ostrem ◽  
Nicholas B. Galifianakis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Motor Cortex ◽  
Brain Stimulation ◽  
Primary Motor Cortex ◽  
Beta Oscillations ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain
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