scholarly journals Reelin Depletion in the Entorhinal Cortex of Human Amyloid Precursor Protein Transgenic Mice and Humans with Alzheimer's Disease

2007 ◽  
Vol 27 (11) ◽  
pp. 2727-2733 ◽  
Author(s):  
J. Chin ◽  
C. M. Massaro ◽  
J. J. Palop ◽  
M. T. Thwin ◽  
G.-Q. Yu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Entorhinal Cortex ◽  
Precursor Protein

Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogenesis

2001 ◽  
Vol 67 ◽  
pp. 195-202 ◽  
Author(s):  
Karen Duff
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Precursor Protein ◽  
Transgenic Mouse Models ◽  
Disease Phenotype

A range of transgenic mice have been created to model Alzheimer's disease. These include mice expressing human forms of the amyloid precursor protein, the presenilins and, more recently, tau. Several of the models develop features of the disease including amyloid pathology, cholinergic deficits, neurodegeneration and cognitive impairment. Progress in the characterization and use of these model animals is discussed.

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