Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3  Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein Phosphorylation

Protein Phosphorylation ◽

Signaling Pathway ◽

Glycogen Synthase ◽

Precursor Protein ◽

Neuroprotective Effects ◽

Transgenic Model ◽

Model Of Alzheimer’S Disease

Faculty Opinions recommendation of Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1105273.561481 ◽

2008 ◽

Author(s):

Riqiang Yan

Keyword(s):

Glycogen Synthase ◽

Tau Phosphorylation ◽

Protein Processing ◽

Precursor Protein ◽

Amyloid Precursor Protein Processing ◽

Cyclin Dependent Kinase ◽

Cyclin Dependent Kinase 5

In vitro streptozotocin model for modeling Alzheimer-like changes: effect on amyloid precursor protein secretases and glycogen synthase kinase-3

Journal of Neural Transmission ◽

10.1007/s00702-014-1319-7 ◽

2014 ◽

Vol 122 (4) ◽

pp. 551-557 ◽

Cited By ~ 15

Author(s):

Konstanze Plaschke ◽

Jürgen Kopitz

Keyword(s):

Glycogen Synthase ◽

Precursor Protein ◽

Glycogen Synthase Kinase 3

Effect of increased glycogen synthase kinase-3 activity upon the maturation of the amyloid precursor protein in transfected cells

Neuroreport ◽

10.1097/00001756-199702100-00012 ◽

1997 ◽

Vol 8 (3) ◽

pp. 639-643 ◽

Cited By ~ 30

Author(s):

Andrew E. Aplin ◽

J Steven Jacobsen ◽

Brian H. Anderton ◽

Jean-Marc Gallo

Keyword(s):

Glycogen Synthase ◽

Precursor Protein ◽

Transfected Cells

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2011.07532.x ◽

2011 ◽

Vol 119 (6) ◽

pp. 1330-1340 ◽

Cited By ~ 51

Author(s):

Tomohiro Onishi ◽

Hiroki Iwashita ◽

Yumiko Uno ◽

Jun Kunitomo ◽

Morihisa Saitoh ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Deficits ◽

Glycogen Synthase ◽

Tau Phosphorylation ◽

Transgenic Model ◽

Model Of Alzheimer’S Disease

P2-531: A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(s)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole (mmbo) decreased tau phosphorylation and ameliorated cognitive deficits in a transgenic model of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.1400 ◽

2011 ◽

Vol 7 ◽

pp. S482-S482

Author(s):

Tomohiro Onishi ◽

Hiroki Iwashita ◽

Yumiko Uno ◽

Jun Kunitomo ◽

Morihisa Saitoh ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Deficits ◽

Glycogen Synthase ◽

Tau Phosphorylation ◽

Transgenic Model ◽

Model Of Alzheimer’S Disease

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3 Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

Journal of Neuroscience ◽

10.1523/jneurosci.5245-07.2008 ◽

2008 ◽

Vol 28 (10) ◽

pp. 2624-2632 ◽

Cited By ~ 91

Author(s):

Y. Wen ◽

E. Planel ◽

M. Herman ◽

H. Y. Figueroa ◽

L. Wang ◽

...

Keyword(s):

Glycogen Synthase ◽

Tau Phosphorylation ◽

Protein Processing ◽

Precursor Protein ◽

Amyloid Precursor Protein Processing ◽

Cyclin Dependent Kinase ◽

Cyclin Dependent Kinase 5

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid- Precursor Protein

Molecular and Cellular Biology ◽

10.1128/mcb.00930-12 ◽

2012 ◽

Vol 32 (21) ◽

pp. 4410-4418 ◽

Cited By ~ 100

Author(s):

C. Parr ◽

R. Carzaniga ◽

S. M. Gentleman ◽

F. Van Leuven ◽

J. Walter ◽

...

Keyword(s):

Glycogen Synthase ◽

Precursor Protein ◽

Autophagic Degradation

Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39291-9 ◽

1990 ◽

Vol 265 (11) ◽

pp. 6061-6065 ◽

Cited By ~ 5

Author(s):

C J Fiol ◽

A Wang ◽

R W Roeske ◽

P J Roach

Keyword(s):

Protein Phosphorylation ◽

Glycogen Synthase ◽

Model Peptide ◽

Peptide Substrates ◽

Phosphorylation Analysis

Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition

Journal of Neuroscience ◽

10.1523/jneurosci.5467-07.2008 ◽

2008 ◽

Vol 28 (10) ◽

pp. 2576-2588 ◽

Cited By ~ 148

Author(s):

Y. Leng ◽

M.-H. Liang ◽

M. Ren ◽

Z. Marinova ◽

P. Leeds ◽

...

Keyword(s):

Valproic Acid ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Glycogen Synthase ◽

Neuroprotective Effects

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

Journal of Neuroscience Research ◽

10.1002/jnr.21787 ◽

2008 ◽

Vol 86 (15) ◽

pp. 3265-3274 ◽

Cited By ~ 154

Author(s):

C.G. Jolivalt ◽

C.A. Lee ◽

K.K. Beiswenger ◽

J.L. Smith ◽

M. Orlov ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Signaling Pathway ◽

Insulin Signaling ◽

Glycogen Synthase ◽

Insulin Signaling Pathway ◽

Diabetic Mice ◽

The Brain