scholarly journals Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study

2015 ◽  
Vol 35 (48) ◽  
pp. 15787-15799 ◽  
Author(s):  
S. Froudist-Walsh ◽  
V. Karolis ◽  
C. Caldinelli ◽  
P. J. Brittain ◽  
J. Kroll ◽  
...  
2007 ◽  
Vol 58 ◽  
pp. S44
Author(s):  
Vladimir V. Klinshov ◽  
Vladimir I. Nekorkin

2020 ◽  
pp. 150-174 ◽  
Author(s):  
André Vandierendonck

The working memory model with distributed executive control accounts for the interactions between working memory and multi-tasking performance. The working memory system supports planned actions by relying on two capacity-limited domain-general and two time-limited domain-specific modules. Domain-general modules are the episodic buffer and the executive module. The episodic buffer stores multimodal representations and uses attentional refreshment to counteract information loss and to consolidate information in episodic long-term memory. The executive module maintains domain-general information relevant for the current task. The phonological buffer and the visuospatial module are domain specific; the former uses inner speech to maintain and to rehearse phonological information, whereas the latter holds visual and spatial representations active by means of image revival. For its operation, working memory interacts with declarative and procedural long-term memory, gets input from sensory registers, and uses the motor system for output.


Author(s):  
Marie-Pascale Noël

This section of this volume deals with the study of numerical impairment occurring either after brain damage (i.e., acquired acalculia) or during development without any known brain damage (i.e., dyscalculia). The chapters in this section will report the research aiming at characterizing those difficulties. The study of atypical number processing and calculation in acalculia has contributed importantly to the understanding of how our brain is structured to process number and to calculate. The study of dyscalculia has shed light on the numerical bases for arithmetic learning. This research has also helped us in determining how other cognitive functions such as working memory, visuospatial processing, or phonological awareness have an impact on numerical cognition. These relations between different cognitive domains could partly explain the co-morbidities that are often observed in developmental disorders. Finally, this section also reviews the few attempts that have been made to enhance those numerical capacities.


2009 ◽  
Vol 20 (1) ◽  
pp. 46-60 ◽  
Author(s):  
Ryu-ichiro Hashimoto ◽  
KangUk Lee ◽  
Alexander Preus ◽  
Robert W. McCarley ◽  
Cynthia G. Wible

Cortex ◽  
2013 ◽  
Vol 49 (9) ◽  
pp. 2283-2293 ◽  
Author(s):  
Jean-Philippe van Dijck ◽  
Wim Gevers ◽  
Christophe Lafosse ◽  
Wim Fias

2005 ◽  
Vol 180 (4) ◽  
pp. 634-643 ◽  
Author(s):  
Christine M. Tipper ◽  
Tara A. Cairo ◽  
Todd S. Woodward ◽  
Anthony G. Phillips ◽  
Peter F. Liddle ◽  
...  

2021 ◽  
Author(s):  
S. C. Barnett ◽  
L.C. Parr-Brownlie ◽  
B. A. L. Perry ◽  
C. K. Young ◽  
H. E. Wicky ◽  
...  

AbstractA hippocampal-diencephalic-cortical network supports memory function. The anterior thalamic nuclei (ATN) form a key anatomical hub within this system. Consistent with this, injury to the mammillary body-ATN axis is associated with examples of clinical amnesia. However, there is only limited and indirect support that the output of ATN neurons actively enhances memory. Here, in rats, we first showed that mammillothalamic tract (MTT) lesions caused a persistent impairment in spatial working memory. MTT lesions also reduced rhythmic electrical activity across the memory system. Next, we introduced 8.5 Hz optogenetic theta-burst stimulation of the ATN glutamatergic neurons. The exogenously-triggered, regular pattern of stimulation produced an acute and substantial improvement of spatial working memory in rats with MTT lesions and enhanced rhythmic electrical activity. Neither behaviour nor rhythmic activity was affected by endogenous stimulation derived from the dorsal hippocampus. Analysis of immediate early gene activity, after the rats foraged for food in an open field, showed that exogenously-triggered ATN stimulation also increased Zif268 expression across memory-related structures. These findings provide clear evidence that increased ATN neuronal activity supports memory. They suggest that ATN-focused gene therapy may be feasible to counter clinical amnesia associated with dysfunction in the mammillary body-ATN axis.HighlightsThe mammillothalamic tract (MTT) supports neural activity in an extended memory system.Optogenetic activation of neurons in the anterior thalamus acutely improves memory after MTT lesions.Rescued memory associates with system-wide neuronal activation and enhanced EEG.Anterior thalamus actively sustains memory and is a feasible therapeutic target.Abstract FigureOptostimulation of anterior thalamus restores memory function after MTT lesionsCreated with BioRender.com


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