Preparation andin vitroevaluation of new pH-sensitive hydrogel beads for oral delivery of protein drugs

2010 ◽  
Vol 115 (5) ◽  
pp. 2828-2837 ◽  
Author(s):  
I. M. El-Sherbiny ◽  
E. M. Abdel-Bary ◽  
D. R. K. Harding
Keyword(s):  
Oral Delivery ◽  
Ph Sensitive ◽  
Protein Drugs ◽  
Hydrogel Beads ◽  
Ph Sensitive Hydrogel

Novel pH-Sensitive Hydrogel Beads Based on Carrageenan and Fish Scale Collagen for Allopurinol Drug Delivery

2020 ◽  
Vol 28 (6) ◽  
pp. 1795-1810 ◽  
Author(s):  
Chinh Thuy Nguyen ◽  
Manh Quoc Vu ◽  
Thuy Thi Phan ◽  
Trung Quoc Vu ◽  
Quan An Vo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Fish Scale ◽  
Hydrogel Beads ◽  
Ph Sensitive Hydrogel

Biodegradable IPN hydrogel beads of pectin and grafted alginate for controlled delivery of diclofenac sodium

2013 ◽  
Vol 24 (5) ◽  
pp. 1179-1190 ◽  
Author(s):  
Tapan Kumar Giri ◽  
Deepa Thakur ◽  
Amit Alexander ◽  
Ajazuddin ◽  
Hemant Badwaik ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Controlled Delivery ◽  
Hydrogel Beads

scholarly journals Fabrication and In Vitro Evaluation of pH-Sensitive Polymeric Hydrogels as Controlled Release Carriers

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 110
Author(s):  
Muhammad Suhail ◽  
Chih-Wun Fang ◽  
Arshad Khan ◽  
Muhammad Usman Minhas ◽  
Pao-Chu Wu
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Acrylic Acid ◽  
Chondroitin Sulfate ◽  
Diclofenac Sodium ◽  
Research Work ◽  
Controlled Delivery ◽  
Scanning Calorimetry ◽  
Release Studies

The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS). Different concentrations of polymers chondroitin sulfate (CS), carbopol 934 (CBP), and monomer acrylic acid (AA) were cross-linked by ethylene glycol dimethylacrylate (EGDMA) in the presence of ammonium peroxodisulfate (APS) (initiator). The fabricated hydrogels were characterized for further experiments. Characterizations such as Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR) were conducted to understand the surface morphology, thermodynamic stability, crystallinity of the drug, ingredients, and developed hydrogels. The swelling and drug release studies were conducted at two different pH mediums (pH 1.2 and 7.4), and pH-dependent swelling and drug release was shown due to the presence of functional groups of both polymers and monomers; hence, greater swelling and drug release was observed at the higher pH (pH 7.4). The percent drug release of the developed system and commercially available product cataflam was compared and high controlled release of the drug from the developed system was observed at both low and high pH. The mechanism of drug release from the hydrogels followed Korsmeyer–Peppas model. Conclusively, the current research work demonstrated that the prepared hydrogel could be considered as a suitable candidate for controlled delivery of diclofenac sodium.

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