THE DISAPPEARANCE RATE OF THYROTROPHIC HORMONE FROM THE BLOODSTREAM OF NORMAL AND THYROIDECTOMIZED RABBITS

Summary 133Xe dissolved in saline was injected into the portal vein in man. Hepatic blood flow was calculated from the disappearance rate of 133Xe recorded with scintillation detectors placed over the liver. The results are discussed and related to simultaneous measurements of the pressure in the portal vein.

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THE EFFECT OF THYROID AND KIDNEY SLICES ON THYROTROPHIC HORMONE ACTIVITY OF THE INCUBATION MEDIUM

Acta Endocrinologica ◽

10.1530/acta.0.0190244 ◽

1955 ◽

Vol 19 (3) ◽

pp. 244-248 ◽

Cited By ~ 3

Author(s):

A. A. H. Kassenaar ◽

H. Kerkhofs

Keyword(s):

Incubation Medium ◽

Hormone Activity ◽

Kidney Slices ◽

Thyrotrophic Hormone

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DISAPPEARANCE RATE OF BOVINE PROLACTIN FROM PLASMA OF FEMALE RATS STUDIED AT INTERVALS OF UP TO 160 MINUTES BY RADIOIMMUNOASSAY

Acta Endocrinologica ◽

10.1530/acta.0.0640718 ◽

1970 ◽

Vol 64 (4) ◽

pp. 718-725 ◽

Cited By ~ 4

Author(s):

A. A. van der Gugten ◽

H. G. Kwa

Keyword(s):

Intravenous Administration ◽

Female Rats ◽

Disappearance Rate ◽

Blood Samples ◽

Dose Dependent

ABSTRACT Plasma values resulting from the intravenous administration of 300, 100, 30 and 10 μ of bovine prolactin to rats on day 1 of pregnancy were followed by taking blood samples after 10, 20, 40, 80 and 160 minutes respectively. The rate of disappearance was found to be dose-dependent and to vary in time in the same rat. It is suggested that at least two processes of elimination take place: 1. a (possibly excretory) process, which can bring »unphysiologically high« prolactin levels down to approximately its treshold level of 1.7 μg/ml and 2. a process, which breaks down the hormone into »immunoreactive« polypeptides. This process can degrade 10 μg of bovine prolactin quantitatively within 10 minutes, but appears to become rapidly »saturated« by larger amounts of the hormone.

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INHIBITION OF THYROGLOBULIN BIOSYNTHESIS AND DEGRADATION BY EXCESS IODIDE. SYNERGISM WITH LITHIUM

Acta Endocrinologica ◽

10.1530/acta.0.0810495 ◽

1976 ◽

Vol 81 (2) ◽

pp. 495-506 ◽

Cited By ~ 9

Author(s):

A. Radvila ◽

R. Roost ◽

H. Bürgi ◽

H. Kohler ◽

H. Studer

Keyword(s):

Protein Synthesis ◽

Thyroid Gland ◽

Inhibitory Action ◽

Inhibit Protein Synthesis ◽

Thyrotrophic Hormone ◽

Thyroid Glands ◽

Pre Treatment ◽

Excess Iodide ◽

Kidney Liver

ABSTRACT Lithium and excess iodide inhibit the release of thyroid hormone from preformed stores. We thus tested the hypothesis that this was due to an inhibition of thyroglobulin breakdown. Rats were pre-treated with propylthiouracil (PTU) for 3 weeks in order to deplete their thyroids of thyroglobulin. While the PTU was continued, lithium chloride (0.25 mEq./100 g weight) or potassium iodide (3 mg per rat) were injected every 12 h for 3 days. Thereafter the thyroglobulin content in thyroid gland homogenates was measured. PTU pre-treatment lowered the thyroglobulin content from 4.21 to 0.22 mg/100 mg gland. Lithium caused a marked re-accumulation of thyroglobulin to 0.60 mg/100 mg within 3 days. While iodide alone had only a borderline effect, it markedly potentiated the action of lithium and a combination of the two drugs increased the thyroglobulin content to 1.04 mg/100 mg. Thyroxine was injected into similarly pre-treated animals to suppress secretion of thyrotrophic hormone. This markedly inhibited the proteolysis of thyroglobulin and 1.3 mg/100 mg gland accumulated after 3 days. Excess iodide, given in addition to thyroxine, decreased the amount of thyroglobulin accumulated to 0.75 mg/100 mg gland. To study whether this could be explained by an inhibitory action of iodide on thyroglobulin biosynthesis, thyroid glands from animals treated with excess iodide were incubated in vitro in the presence of 0.2 mm iodide for 3 h. Iodide decreased the incorporation of radioactive leucine into total thyroidal protein and into thyroglobulin by 25 and 35 % respectively. Iodide did not inhibit protein synthesis in the kidney, liver or muscle tissue. Thus, large doses of iodide selectively inhibit thyroglobulin biosynthesis.

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Pharmacodynamics of [D-Ser (t-Bu), Des-Gly]GnRH ethylamide (Buserelin®) in 6 normal volunteers.

Acta Endocrinologica ◽

10.1530/acta.0.1150235 ◽

1987 ◽

Vol 115 (2) ◽

pp. 235-242 ◽

Cited By ~ 3

Author(s):

Y. Reznik ◽

B. P. Winiger ◽

M. L. Aubert ◽

P. C. Sizonenko

Keyword(s):

Urinary Excretion ◽

Precocious Puberty ◽

Plasma Levels ◽

Intranasal Administration ◽

Cross Reaction ◽

Disappearance Rate ◽

Gnrh Analog ◽

Male Adolescents ◽

Normal Volunteers ◽

The Mean

Abstract. The disappearance rate of [D-Ser(t-bu)6,des-Gly10]GnRH ethylamide (Buserelin®, HOE 766) was studied in plasma and urine after intranasal (300 μg) or sc (10 μg/kg) administration. A radioimmunoassay for HOE 766 was developed using 125I[D-Trp6,Des-Gly10]GnRH ethylamide as tracer and an antiserum raised against HOE 766. Cross-reaction with native GnRH was only 1.7%. Sensitivity was 1 pg/tube. In 6 male adolescents, the mean plasma HOE 766 concentration (± sem) was 0.46 ± 0.08, 0.50 ± 0.10, 0.28 ± 0.04, 0.24 ± 0.04, 0.13 ± 0.03, and 0.08 ± 0.02 μg/l 30, 60, 90, 120 and 180 min after the intranasal administration, respectively. Concomitant urinary excretion of HOE 766-like material was 9.43 ± 1.96 μg/4 h. There was a good correlation between integrated plasma levels and urinary excretion (r = 0.92). In the same 6 volunteers, the plasma HOE 766 levels were 21.2 ± 3.0, 25.9 ± 0.8, 21.2 ± 0.9, 17.1 ± 0.7, 12.8 ± 1.1, 8.9 ± 0.4, and 5.9 ± 0.8 μg/l 20, 40, 60, 90, 120, 180 and 240 min after sc injection, respectively. The mean urinary excretion was 543 ± 61 μg/4 h. In two girls with precocious puberty treated during 12 to 15 months with intranasal administration of HOE 766, urinary excretion of HOE 766-like material was shown to correlate well with the degree of inhibition of plasma 17β-E2and of plasma LH and FSH responses to a GnRH challenge. Thus, monitoring of HOE 766 in urine appears to be helpful for evaluating of intranasal therapy with a GnRH analog in precocious puberty.

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Prognostic implications of disappearance rate of biologic markers following radical prostatectomy

Urology ◽

10.1016/s0090-4295(90)80287-w ◽

1990 ◽

Vol 36 (5) ◽

pp. 415-419 ◽

Cited By ~ 18

Author(s):

J.E. Pontes ◽

P. Jabalameli ◽

J. Montie ◽

R. Foemmel ◽

P.D. Howard ◽

...

Keyword(s):

Radical Prostatectomy ◽

Disappearance Rate ◽

Biologic Markers ◽

Prognostic Implications

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Rapid Infusion of Hydroxyethyl Starch 70/0.5 but not Acetate Ringer’s Solution Decreases the Plasma Concentration of Propofol during Target-controlled Infusion

Anesthesiology ◽

10.1097/aln.0000000000001184 ◽

2016 ◽

Vol 125 (2) ◽

pp. 304-312 ◽

Cited By ~ 8

Author(s):

Sayako Itakura ◽

Kenichi Masui ◽

Tomiei Kazama

Keyword(s):

Blood Flow ◽

Plasma Concentration ◽

Indocyanine Green ◽

Blood Volume ◽

Hydroxyethyl Starch ◽

Hepatic Blood Flow ◽

Disappearance Rate ◽

Rapid Infusion ◽

Ringer’S Solution ◽

Target Controlled Infusion

Abstract Background Rapid fluid infusion resulting in increased hepatic blood flow may decrease the propofol plasma concentration (Cp) because propofol is a high hepatic extraction drug. The authors investigated the effects of rapid colloid and crystalloid infusions on the propofol Cp during target-controlled infusion. Methods Thirty-six patients were randomly assigned to 1 of 3 interventions (12 patients per group). At least 30 min after the start of propofol infusion, patients received either a 6% hydroxyethyl starch (HES) solution at 24 ml·kg−1·h−1 or acetated Ringer’s solution at 24 or 2 ml·kg−1·h−1 during the first 20 min. In all groups, acetated Ringer’s solution was infused at 2 ml·kg−1·h−1 during the next 20 min. The propofol Cp was measured every 2.5 min as the primary outcome. Cardiac output, blood volume, and indocyanine green disappearance rate were determined using a pulse dye densitogram analyzer before and after the start of fluid administration. Effective hepatic blood flow was calculated as the blood volume multiplied by the indocyanine green disappearance rate. Results The rapid HES infusion significantly decreased the propofol Cp by 22 to 37%, compared to the Cp at 0 min, whereas the rapid or maintenance infusion of acetate Ringer’s solution did not decrease the propofol Cp. Rapid HES infusion, but not acetate Ringer’s solution infusion, increased the effective hepatic blood flow. Conclusions Rapid HES infusion increased the effective hepatic blood flow, resulting in a decreased propofol Cp during target-controlled infusion. Rapid HES infusion should be used cautiously as it may decrease the depth of anesthesia.

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