THE EFFECT OF THYROTROPHIC HORMONE ON THE PLASMA THYROID HORMONES IN MAN

1963 ◽  
Vol 12 (1) ◽  
pp. 30-36 ◽  
Author(s):  
MAURICE L. WELLBY ◽  
BASIL S. HETZEL ◽  
MARGARET L. ISAACHSEN
Keyword(s):  
Thyroid Hormones ◽  
Thyrotrophic Hormone

METABOLISM AND FUNCTIONS OF PHOSPHATIDES

1961 ◽  
Vol 36 (1) ◽  
pp. 9-21 ◽  
Author(s):  
F. Kögl ◽  
L. L. M. van Deenen
Keyword(s):  
Thyroid Hormones ◽  
Direct Effect ◽  
P Uptake ◽  
Structural Function ◽  
Class A ◽  
Thyrotrophic Hormone ◽  
Iodine Metabolism ◽  
Column Chromatographic ◽  
Stimulation Of

ABSTRACT The TSH (thyrotrophic hormone) induced stimulation of the rate of incorporation of radioactive phosphate into the phosphatides of the thyroid was studied in vitro. Since neither thyroid hormones nor agents blocking iodine metabolism altered the 32P uptake, a direct effect of TSH on thyrophosphatides was assumed. Paper and column chromatographic experiments on phosphatides isolated from beef thyroid slices after incubation with TSH demonstrated that the 32P incorporation occurs into lecithins, cephalins and an inositol-phosphatide. The action of TSH on thyrophosphatides did not appear to be restricted to one cell fraction, while the TSH controlled phosphatides appeared to belong to the so-called bound class. A structural function of the thyro-phosphatides is discussed.

THYROTROPHIC HORMONE ACTIVITY IN HYPOPHYSECTOMIZED RATS EXPOSED TO COLD AND RECEIVING ASCORBIC ACID

1958 ◽  
Vol 36 (11) ◽  
pp. 1099-1104
Author(s):  
André DesMarais
Keyword(s):  
Ascorbic Acid ◽  
Thyroid Hormones ◽  
Room Temperature ◽  
Hormone Activity ◽  
Exposure To Cold ◽  
Thyrotrophic Hormone ◽  
Hypophysectomized Rats

Hypophysectomized rats were treated for 5 days with 0.05 unit of thyrotrophic hormone (TSH) daily, with or without administration of 150 mg of ascorbate per day, and either exposed to cold (14 °C) or kept at room temperature (24 °C). No effect of exposure to cold or ascorbate treatment could be observed on the thyroid–TSH relationship. Any effect of ascorbate treatment in these animals appears to be mediated through the circulating thyroid hormones.

NON BUTANOL EXTRACTABLE IODINE IN THE SERUM OF EUMETABOLIC ADULT GOITRE PATIENTS

1963 ◽  
Vol 44 (2) ◽  
pp. 291-312 ◽  
Author(s):  
B.-A. Lamberg ◽  
G. Hintze ◽  
R. Karlsson
Keyword(s):  
Enzymatic Hydrolysis ◽  
Thyroid Hormones ◽  
Test Dose ◽  
Subtotal Thyroidectomy ◽  
Endemic Goitre ◽  
Thyrotrophic Hormone ◽  
The Difference ◽  
Do So ◽  
Insoluble Portion

ABSTRACT In studies on endemic goitre there were 20 patients who had more than a normal proportion of butanol insoluble iodine in the serum. All these patients were eumetabolic adults with a goitre ranging in size from 50 to 300 g. The insoluble portion of the PB131I (NBE131I) varied from 25 to 80 per cent, the PB131I from 0.005 to 0.94% per litre. Radiochromatography of the extract revealed that thyroxine made up 30 to 100 per cent, the remainder being iodide. In one case instead of thyroxine, 48 per cent of triiodothyronine was found. In one case traces of diiodotyrosine were found 6 hours after the test dose. Enzymatic hydrolysis increased the extractability in two cases but failed to do so in two other cases. The responses of PBI, PB131I to stimulation with thyrotrophic hormone were studied in some instances. There was usually a good response of PBI and PB131I. The reaction of NBE131I, however, was nil, or very small. The ratio between the values obtained after and before stimulation varied from 1.0 to 1.3. In contrast there was a marked increase in the difference PB131I – NBE131I which presumably represented thyroid hormones. The ratio varied from 2.5 to 3.2. In one case restudied 5 weeks and 3 months after subtotal thyroidectomy the same situation was observed. The occurrence of NBE131I was observed in two members of a family in two instances. In some other families the pedigree was also highly suggestive of an inherited disorder, although it must be admitted that the

THYROTROPHIC HORMONE ACTIVITY IN HYPOPHYSECTOMIZED RATS EXPOSED TO COLD AND RECEIVING ASCORBIC ACID

1958 ◽  
Vol 36 (1) ◽  
pp. 1099-1104
Author(s):  
André DesMarais
Keyword(s):  
Ascorbic Acid ◽  
Thyroid Hormones ◽  
Room Temperature ◽  
Hormone Activity ◽  
Exposure To Cold ◽  
Thyrotrophic Hormone ◽  
Hypophysectomized Rats

Hypophysectomized rats were treated for 5 days with 0.05 unit of thyrotrophic hormone (TSH) daily, with or without administration of 150 mg of ascorbate per day, and either exposed to cold (14 °C) or kept at room temperature (24 °C). No effect of exposure to cold or ascorbate treatment could be observed on the thyroid–TSH relationship. Any effect of ascorbate treatment in these animals appears to be mediated through the circulating thyroid hormones.

259 Thyroid hormones in chronic heart failure outpatients

2006 ◽  
Vol 5 (1) ◽  
pp. 56-56
Author(s):  
A BARISON ◽  
L RONDININI ◽  
S GUIDERI ◽  
M COCEANI ◽  
M SCARLATTINI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Thyroid Hormones

The Role of Zinc in Thyroid Hormones Metabolism

2019 ◽  
Vol 89 (1-2) ◽  
pp. 80-88 ◽  
Author(s):  
Juliana Soares Severo ◽  
Jennifer Beatriz Silva Morais ◽  
Taynáh Emannuelle Coelho de Freitas ◽  
Ana Letícia Pereira Andrade ◽  
Mayara Monte Feitosa ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Scientific Evidence ◽  
Thyroid Stimulating Hormone ◽  
Zinc Transporters ◽  
Serum Concentrations ◽  
Metabolic Adaptations ◽  
Serum T3 ◽  
Regulatory Effects ◽  
Shed Light

Abstract. Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. It is known to regulate both the synthesis and mechanism of action of these hormones. In the present review, we aim to shed light on the regulatory effects of zinc on thyroid hormones. Scientific evidence shows that zinc plays a key role in the metabolism of thyroid hormones, specifically by regulating deiodinases enzymes activity, thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH) synthesis, as well as by modulating the structures of essential transcription factors involved in the synthesis of thyroid hormones. Serum concentrations of zinc also appear to influence the levels of serum T3, T4 and TSH. In addition, studies have shown that Zinc transporters (ZnTs) are present in the hypothalamus, pituitary and thyroid, but their functions remain unknown. Therefore, it is important to further investigate the roles of zinc in regulation of thyroid hormones metabolism, and their importance in the treatment of several diseases associated with thyroid gland dysfunction.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

Transient Prealbumin- Associated Hyperthyroxinemia in TSH-Producing Pituitary Adenoma

1990 ◽  
Vol 29 (01) ◽  
pp. 40-43 ◽  
Author(s):  
W. Langsteger ◽  
P. Költringer ◽  
P. Wakonig ◽  
B. Eber ◽  
M. Mokry ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Pituitary Adenoma ◽  
Thyroid Hormones ◽  
Protein Binding ◽  
Alpha Subunit ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
Free Thyroid Hormones ◽  
Transmission Computed Tomography

This case report describes a 38-year-old male who was hospitalized for further clarification of clinically mild hyperthyroidism. His increased total hormone levels, the elevated free thyroid hormones and the elevated basal TSH with blunted response to TRH strongly suggested a pituitary adenoma with inappropriate TSH incretion. Transmission computed tomography showed an intrasellar expansion, 16 mm in diameter. The neoplastic TSH production was confirmed by an elevated alpha-subunit and a raised molar alpha-sub/ATSH ratio. However, T4 distribution on prealbumin (PA, TTR), albumin (A) and thyroxine binding globulin (TBG) showed a clearly increased binding to PA (39%), indicating additional prealbumin-associated hyperthyroxinemia. The absolute values of PA, A and TBG were within the normal range. After removal of the TSH-producing adenoma, basal TSH, the free thyroid hormones and T4 binding to prealbumin returned to normal. Therefore, the prealbumin-associated hyperthyroxinemia had to be interpreted as a transitory phenomenon related to secondary hyperthyroidism (T4 shift from thyroxine binding globulin to prealbumin) rather than a genetically conditioned anomaly of protein binding.

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